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The integration of large language models (LLMs) into medical practice offers transformative potential, yet their real-world clinical applicability remains constrained by critical alignment issues: (1) a misalignment between static…

人工智能 · 计算机科学 2025-12-05 Yongnan Jin , Xurui Li , Feng Cao , Liucun Gao , Juanjuan Yao

Although large language models (LLMs) demonstrate expert-level medical knowledge, aligning their open-ended outputs with fine-grained clinician preferences remains challenging. Existing methods often rely on coarse objectives or unreliable…

人工智能 · 计算机科学 2026-02-12 Shiwei Lyu , Xidong Wang , Lei Liu , Hao Zhu , Chaohe Zhang , Jian Wang , Jinjie Gu , Benyou Wang , Yue Shen

While reinforcement learning for large language model alignment has progressed rapidly in recent years, transferring these paradigms to high-stakes medical question answering reveals a fundamental paradigm mismatch. Reinforcement Learning…

Process-Level Reward Models (PRMs) are essential for guiding complex reasoning in large language models, yet existing PRM benchmarks cover only general domains such as mathematics, failing to address medical reasoning -- which is uniquely…

计算与语言 · 计算机科学 2026-04-21 Lingyan Wu , Xiang Zheng , Weiqi Zhai , Wei Wang , Xuan Ren , Zifan Zhang , Hu Wei , Bing Zhao

Process-supervised reward models (PRMs) excel at providing step-by-step verification for large language model (LLM) outputs in domains like mathematics and coding. However, their application to fields lacking ground-truth answers, such as…

Automatic medical report generation can greatly reduce the workload of doctors, but it is often unreliable for real-world deployment. Current methods can write formally fluent sentences but may be factually flawed, introducing serious…

计算工程、金融与科学 · 计算机科学 2025-12-03 Yuan Wang , Shujian Gao , Jiaxiang Liu , Songtao Jiang , Haoxiang Xia , Xiaotian Zhang , Zhaolu Kang , Yemin Wang , Zuozhu Liu

Interactive medical questioning is essential in real-world clinical consultations, where physicians must actively gather information from patients. While medical Large Language Models (LLMs) have shown impressive capabilities in static…

计算与语言 · 计算机科学 2025-08-20 Hongxin Ding , Baixiang Huang , Yue Fang , Weibin Liao , Xinke Jiang , Zheng Li , Junfeng Zhao , Yasha Wang

Large language models have shown promise in clinical decision making, but current approaches struggle to localize and correct errors at specific steps of the reasoning process. This limitation is critical in medicine, where identifying and…

Pre-trained large-scale language models (LLMs) excel at producing coherent articles, yet their outputs may be untruthful, toxic, or fail to align with user expectations. Current approaches focus on using reinforcement learning with human…

计算与语言 · 计算机科学 2024-06-06 Dehong Xu , Liang Qiu , Minseok Kim , Faisal Ladhak , Jaeyoung Do

Recent researches of large language models(LLM), which is pre-trained on massive general-purpose corpora, have achieved breakthroughs in responding human queries. However, these methods face challenges including limited data insufficiency…

计算与语言 · 计算机科学 2025-01-07 Yiming Zhang , Zheng Chang , Wentao Cai , MengXing Ren , Kang Yuan , Yining Sun , Zenghui Ding

Large language models (LLMs) hold transformative potential for medical decision support yet their application in psychiatry remains constrained by hallucinations and superficial reasoning. This limitation is particularly acute in…

Reward-model-based fine-tuning is a central paradigm in aligning Large Language Models with human preferences. However, such approaches critically rely on the assumption that proxy reward models accurately reflect intended supervision, a…

计算与语言 · 计算机科学 2026-01-21 Zixuan Liu , Siavash H. Khajavi , Guangkai Jiang , Xinru Liu

Large Language Models (LLMs) are increasingly used in healthcare, yet ensuring their safety and trustworthiness remains a barrier to deployment. Conversational medical assistants must avoid unsafe compliance without over-refusing benign…

人工智能 · 计算机科学 2025-12-05 Huy Nghiem , Swetasudha Panda , Devashish Khatwani , Huy V. Nguyen , Krishnaram Kenthapadi , Hal Daumé

Evaluating large language models (LLMs) in medicine is crucial because medical applications require high accuracy with little room for error. Current medical benchmarks have three main types: medical exam-based, comprehensive medical, and…

The rapid advancement of large language models (LLMs) has accelerated their integration into clinical decision support, particularly in prescription review. To enable systematic and fine-grained evaluation, we developed RxBench, a…

We address the problem of making a pre-trained reinforcement learning (RL) policy safety-aware by incorporating cost constraints without retraining it from scratch. While costs could be numerically encoded, we assume a more general setting…

机器学习 · 计算机科学 2026-05-21 Richa Verma , Bavish Kulur , Sanjay Chawla , Balaraman Ravindran

In the rapidly evolving landscape of large language models (LLMs) for medical applications, ensuring the reliability and accuracy of these models in clinical settings is paramount. Existing benchmarks often focus on fixed-format tasks like…

计算与语言 · 计算机科学 2025-01-14 Shunfan Zheng , Xiechi Zhang , Gerard de Melo , Xiaoling Wang , Linlin Wang

Prompt engineering significantly influences the reliability and clinical utility of Large Language Models (LLMs) in medical applications. Current optimization approaches inadequately address domain-specific medical knowledge and safety…

计算与语言 · 计算机科学 2025-08-26 Yinda Chen , Yangfan He , Jing Yang , Dapeng Zhang , Zhenlong Yuan , Muhammad Attique Khan , Jamel Baili , Por Lip Yee

Recent self-rewarding large language models (LLM) have successfully applied LLM-as-a-Judge to iteratively improve the alignment performance without the need of human annotations for preference data. These methods commonly utilize the same…

机器学习 · 计算机科学 2025-04-29 Zhaoyang Wang , Weilei He , Zhiyuan Liang , Xuchao Zhang , Chetan Bansal , Ying Wei , Weitong Zhang , Huaxiu Yao

Large Language Models (LLMs) have demonstrated remarkable capabilities across various domains and are moving towards more specialized areas. Recent advanced proprietary models such as GPT-4 and Gemini have achieved significant advancements…

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