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In the context of time-series forecasting, we propose a LSTM-based recurrent neural network architecture and loss function that enhance the stability of the predictions. In particular, the loss function penalizes the model, not only on the…

信号处理 · 电气工程与系统科学 2020-09-09 Maxime De Bois , Mounîm A. El Yacoubi , Mehdi Ammi

Reinforcement Learning (RL) is a computational approach to reward-driven learning in sequential decision problems. It implements the discovery of optimal actions by learning from an agent interacting with an environment rather than from…

统计方法学 · 统计学 2022-10-06 Mauricio Tec , Yunshan Duan , Peter Müller

Continuous glucose monitoring (CGM) is central to diabetes care, but explaining CGM patterns clearly and empathetically remains time-intensive. Evidence for retrieval-grounded large language model (LLM) systems in CGM-informed counseling…

Type 2 diabetes prevention and treatment can benefit from personalized lifestyle prescriptions. However, the delivery of personalized lifestyle medicine prescriptions is limited by the shortage of trained professionals and the variability…

应用统计 · 统计学 2025-11-03 Yuhan Tang

Blood glucose (BG) management is crucial for type-1 diabetes patients resulting in the necessity of reliable artificial pancreas or insulin infusion systems. In recent years, deep learning techniques have been utilized for a more accurate…

机器学习 · 计算机科学 2021-01-19 Md Fazle Rabby , Yazhou Tu , Md Imran Hossen , Insup Le , Anthony S Maida , Xiali Hei

Glycemic control is essential for critical care. However, it is a challenging task because there has been no study on personalized optimal strategies for glycemic control. This work aims to learn personalized optimal glycemic trajectories…

机器学习 · 计算机科学 2017-12-05 Wei-Hung Weng , Mingwu Gao , Ze He , Susu Yan , Peter Szolovits

In this paper, we present a model free approach to calculate long-acting insulin doses for Type 2 Diabetic (T2D) subjects in order to bring their blood glucose (BG) concentration to be within a safe range. The proposed strategy tunes the…

系统与控制 · 电气工程与系统科学 2022-12-29 Mohamad Al Ahdab , Torben Knudsen , Jakob Stoustrup , John Leth

Diabetes cases worldwide have risen steadily over the past decades, lending urgency to the search for more efficient, effective, and personalized ways to treat the disease. Current treatment strategies, however, may fail to maintain…

组织与器官 · 定量生物学 2014-03-05 S. M. Kissler , C. Cichowitz , S. Sankaranarayanan , D. M. Bortz

Offline reinforcement learning (RL) optimizes the policy on a previously collected dataset without any interactions with the environment, yet usually suffers from the distributional shift problem. To mitigate this issue, a typical solution…

机器学习 · 计算机科学 2023-09-06 Qisen Yang , Shenzhi Wang , Qihang Zhang , Gao Huang , Shiji Song

The dead-in-bed syndrome describes the sudden and unexplained death of young individuals with Type 1 Diabetes (T1D) without prior long-term complications. One leading hypothesis attributes this phenomenon to nocturnal hypoglycemia (NH), a…

机器学习 · 计算机科学 2025-04-15 Marco Voegeli , Sonia Laguna , Heike Leutheuser , Marc Pfister , Marie-Anne Burckhardt , Julia E Vogt

Medical treatments often involve a sequence of decisions, each informed by previous outcomes. This process closely aligns with reinforcement learning (RL), a framework for optimizing sequential decisions to maximize cumulative rewards under…

机器学习 · 计算机科学 2024-10-15 Ali Shirali , Alexander Schubert , Ahmed Alaa

The classification of diabetes and prediabetes by static glucose thresholds obscures the pathophysiological dysglycemia heterogeneity, primarily driven by insulin resistance (IR), beta-cell dysfunction, and incretin deficiency. This review…

机器学习 · 计算机科学 2025-11-07 Ahmed A. Metwally , Heyjun Park , Yue Wu , Tracey McLaughlin , Michael P. Snyder

Classifier free guidance has shown strong potential in diffusion-based reinforcement learning. However, existing methods rely on joint training of the guidance module and the diffusion model, which can be suboptimal during the early stages…

机器学习 · 计算机科学 2025-06-05 Zhaoyang Chen , Cody Fleming

Despite the well-acknowledged benefits of physical activity for type 2 diabetes (T2D) prevention, the literature surprisingly lacks validated models able to predict the long-term benefits of exercise on T2D progression and support…

系统与控制 · 电气工程与系统科学 2024-04-24 Pierluigi Francesco De Paola , Alessandro Borri , Fabrizio Dabbene , Karim Keshavjee , Pasquale Palumbo , Alessia Paglialonga

Care coordination and population health management programs serve large Medicaid and safety-net populations and must be auditable, efficient, and adaptable. While clinical risk for outreach modalities is typically low, time and opportunity…

计算机与社会 · 计算机科学 2025-09-23 Sanjay Basu , Sadiq Y. Patel , Parth Sheth , Bhairavi Muralidharan , Namrata Elamaran , Aakriti Kinra , Rajaie Batniji

Dynamic treatment regimens (DTRs) aim at tailoring individualized sequential treatment rules that maximize cumulative beneficial outcomes by accommodating patients' heterogeneity in decision-making. For many chronic diseases including type…

统计方法学 · 统计学 2024-04-23 Mochuan Liu , Yuanjia Wang , Haoda Fu , Donglin Zeng

The ability to discover optimal behaviour from fixed data sets has the potential to transfer the successes of reinforcement learning (RL) to domains where data collection is acutely problematic. In this offline setting, a key challenge is…

机器学习 · 计算机科学 2022-11-23 Alex Beeson , Giovanni Montana

This paper presents a real time, data driven decision support framework for epidemic control. We combine a compartmental epidemic model with sequential Bayesian inference and reinforcement learning (RL) controllers that adaptively choose…

统计方法学 · 统计学 2025-11-25 Giacomo Iannucci , Petros Barmpounakis , Alexandros Beskos , Nikolaos Demiris

This paper is a study of reinforcement learning (RL) as an optimal-control strategy for control of nonlinear valves. It is evaluated against the PID (proportional-integral-derivative) strategy, using a unified framework. RL is an autonomous…

机器学习 · 计算机科学 2021-02-05 Rajesh Siraskar

Reinforcement learning (RL) applications in Clinical Decision Support Systems (CDSS) frequently encounter skepticism because models may recommend inoperable dosing decisions. We propose an end-to-end offline RL framework for dual…