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The automated analysis of chemical literature holds promise to accelerate discovery in fields such as material science and drug development. In particular, search capabilities for chemical structures and Markush structures (chemical…

计算机视觉与模式识别 · 计算机科学 2025-10-09 Lucas Morin , Valéry Weber , Ahmed Nassar , Gerhard Ingmar Meijer , Luc Van Gool , Yawei Li , Peter Staar

In recent decades, chemistry publications and patents have increased rapidly. A significant portion of key information is embedded in molecular structure figures, complicating large-scale literature searches and limiting the application of…

计算机视觉与模式识别 · 计算机科学 2025-09-22 Xi Fang , Jiankun Wang , Xiaochen Cai , Shangqian Chen , Shuwen Yang , Haoyi Tao , Nan Wang , Lin Yao , Linfeng Zhang , Guolin Ke

The automatic analysis of chemical literature has immense potential to accelerate the discovery of new materials and drugs. Much of the critical information in patent documents and scientific articles is contained in figures, depicting the…

计算机视觉与模式识别 · 计算机科学 2024-08-29 Lucas Morin , Martin Danelljan , Maria Isabel Agea , Ahmed Nassar , Valery Weber , Ingmar Meijer , Peter Staar , Fisher Yu

For several decades, chemical knowledge has been published in written text, and there have been many attempts to make it accessible, for example, by transforming such natural language text to a structured format. Although the discovered…

计算机视觉与模式识别 · 计算机科学 2022-02-22 Sanghyun Yoo , Ohyun Kwon , Hoshik Lee

Optical Chemical Structure Recognition (OCSR) is critical for converting 2D molecular diagrams from printed literature into machine-readable formats. While Vision-Language Models have shown promise in end-to-end OCR tasks, their direct…

计算机视觉与模式识别 · 计算机科学 2026-04-22 Haocheng Tang , Xingyu Dang , Junmei Wang

Molecular structures are always depicted as 2D printed form in scientific documents like journal papers and patents. However, these 2D depictions are not machine-readable. Due to a backlog of decades and an increasing amount of these…

Chemical structure extraction from documents remains a hard problem due to both false positive identification of structures during segmentation and errors in the predicted structures. Current approaches rely on handcrafted rules and…

机器学习 · 计算机科学 2018-02-15 Joshua Staker , Kyle Marshall , Robert Abel , Carolyn McQuaw

In drug discovery, knowledge of the graph structure of chemical compounds is essential. Many thousands of scientific articles in chemistry and pharmaceutical sciences have investigated chemical compounds, but in cases the details of the…

机器学习 · 统计学 2020-09-16 Martijn Oldenhof , Adam Arany , Yves Moreau , Jaak Simm

We present Multimodal OCR (MOCR), a document parsing paradigm that jointly parses text and graphics into unified textual representations. Unlike conventional OCR systems that focus on text recognition and leave graphical regions as cropped…

We present an end-to-end trainable approach for Optical Character Recognition (OCR) on printed documents. Specifically, we propose a model that predicts a) a two-dimensional character grid (\emph{chargrid}) representation of a document…

计算机视觉与模式识别 · 计算机科学 2020-02-28 Christian Reisswig , Anoop R Katti , Marco Spinaci , Johannes Höhne

As global trends are shifting towards data-driven industries, the demand for automated algorithms that can convert digital images of scanned documents into machine readable information is rapidly growing. Besides the opportunity of data…

计算机视觉与模式识别 · 计算机科学 2021-05-25 Pascal Fischer , Alen Smajic , Alexander Mehler , Giuseppe Abrami

Understanding the chemical structure from a graphical representation of a molecule is a challenging image caption task that would greatly benefit molecule-centric scientific discovery. Variations in molecular images and caption subtasks…

计算机视觉与模式识别 · 计算机科学 2025-05-23 Siqi Fan , Yuguang Xie , Bowen Cai , Ailin Xie , Gaochao Liu , Mu Qiao , Jie Xing , Zaiqing Nie

We introduce a novel type of text representation that preserves the 2D layout of a document. This is achieved by encoding each document page as a two-dimensional grid of characters. Based on this representation, we present a generic…

Like many scientific fields, new chemistry literature has grown at a staggering pace, with thousands of papers released every month. A large portion of chemistry literature focuses on new molecules and reactions between molecules. Most…

定量方法 · 定量生物学 2021-09-10 Daniel Campos , Heng Ji

Document parsing has recently advanced with multimodal large language models (MLLMs) that directly map document images to structured outputs. Traditional cascaded pipelines depend on precise layout analysis and often fail under casually…

计算机视觉与模式识别 · 计算机科学 2026-04-21 Gengluo Li , Pengyuan Lyu , Chengquan Zhang , Huawen Shen , Liang Wu , Xingyu Wan , Gangyan Zeng , Han Hu , Can Ma , Yu Zhou

We present MMOCR-an open-source toolbox which provides a comprehensive pipeline for text detection and recognition, as well as their downstream tasks such as named entity recognition and key information extraction. MMOCR implements 14…

计算机视觉与模式识别 · 计算机科学 2021-08-17 Zhanghui Kuang , Hongbin Sun , Zhizhong Li , Xiaoyu Yue , Tsui Hin Lin , Jianyong Chen , Huaqiang Wei , Yiqin Zhu , Tong Gao , Wenwei Zhang , Kai Chen , Wayne Zhang , Dahua Lin

The problem of accelerating drug discovery relies heavily on automatic tools to optimize precursor molecules to afford them with better biochemical properties. Our work in this paper substantially extends prior state-of-the-art on…

化学物理 · 物理学 2019-10-22 Wengong Jin , Regina Barzilay , Tommi Jaakkola

There is increasing adoption of artificial intelligence in drug discovery. However, existing studies use machine learning to mainly utilize the chemical structures of molecules but ignore the vast textual knowledge available in chemistry.…

机器学习 · 计算机科学 2024-01-31 Shengchao Liu , Weili Nie , Chengpeng Wang , Jiarui Lu , Zhuoran Qiao , Ling Liu , Jian Tang , Chaowei Xiao , Anima Anandkumar

Most molecular diagram parsers recover chemical structure from raster images (e.g., PNGs). However, many PDFs include commands giving explicit locations and shapes for characters, lines, and polygons. We present a new parser that uses these…

计算机视觉与模式识别 · 计算机科学 2025-02-27 Ayush Kumar Shah , Bryan Manrique Amador , Abhisek Dey , Ming Creekmore , Blake Ocampo , Scott Denmark , Richard Zanibbi

Optical Chemical Structure Recognition (OCSR) plays a pivotal role in modern chemical informatics, enabling the automated conversion of chemical structure images from scientific literature, patents, and educational materials into…

计算机视觉与模式识别 · 计算机科学 2025-11-24 Wenrui Zhang , Xinggang Wang , Bin Feng , Wenyu Liu
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