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Designing full-length, epitope-specific TCR {\alpha}\b{eta} remains challenging due to vast sequence space, data biases and incomplete modeling of immunogenetic constraints. We present LSMTCR, a scalable multi-architecture framework that…

计算工程、金融与科学 · 计算机科学 2025-10-09 Ruihao Zhang , Xiao Liu

Modern therapeutic antibody design often involves composing multi-part assemblages of individual functional domains, each of which may be derived from a different source or engineered independently. While these complex formats can expand…

机器学习 · 计算机科学 2025-09-25 Jiayi Xin , Aniruddh Raghu , Nick Bhattacharya , Adam Carr , Melanie Montgomery , Hunter Elliott

Code generation models have increasingly become integral to aiding software development. Although current research has thoroughly examined the correctness of the code produced by code generation models, a vital aspect that plays a pivotal…

软件工程 · 计算机科学 2025-05-13 Dong Huang , Yuhao Qing , Weiyi Shang , Heming Cui , Jie M. Zhang

Large Language Models (LLMs) have transformed how people interact with artificial intelligence (AI) systems, achieving state-of-the-art results in various tasks, including scientific discovery and hypothesis generation. However, the lack of…

计算与语言 · 计算机科学 2024-11-06 Sikun Guo , Amir Hassan Shariatmadari , Guangzhi Xiong , Albert Huang , Eric Xie , Stefan Bekiranov , Aidong Zhang

Inaccuracies in existing or generated clinical text may lead to serious adverse consequences, especially if it is a misdiagnosis or incorrect treatment suggestion. With Large Language Models (LLMs) increasingly being used across diverse…

Many of the most important problems in science and engineering are inverse problems: given a desired outcome, find a design that achieves it. Evaluating whether a candidate meets the spec is often routine; a binding energy can be computed,…

机器学习 · 计算机科学 2026-03-16 David van Dijk , Ivan Vrkic

This registered report introduces the largest, and for the first time, reproducible experimental survey on biomedical sentence similarity with the following aims: (1) to elucidate the state of the art of the problem; (2) to solve some…

计算与语言 · 计算机科学 2023-01-11 Alicia Lara-Clares , Juan J. Lastra-Díaz , Ana Garcia-Serrano

As a future trend of healthcare, personalized medicine tailors medical treatments to individual patients. It requires to identify a subset of patients with the best response to treatment. The subset can be defined by a biomarker (e.g.…

统计方法学 · 统计学 2021-08-16 Yitao Lu , Julie Zhou , Li Xing , Xuekui Zhang

Rapid progress in aerodynamic shape optimization (ASO) has outpaced currently-available standardized evaluation frameworks. Fair comparison requires a unified benchmark spanning diverse shape classes, objective formulations, and…

机器学习 · 计算机科学 2026-05-21 Shaghayegh Fazliani , Krissh Chawla , Jack Guo , Yiren Shen , Matthias Ihme , Madeleine Udell

As LLMs achieved breakthroughs in general reasoning, their proficiency in specialized scientific domains reveals pronounced gaps in existing benchmarks due to data contamination, insufficient complexity, and prohibitive human labor costs.…

Large language models (LLMs) have become increasingly pivotal across various domains, especially in handling complex data types. This includes structured data processing, as exemplified by ChartQA and ChatGPT-Ada, and multimodal…

Evaluation plays a crucial role in the advancement of information retrieval (IR) models. However, current benchmarks, which are based on predefined domains and human-labeled data, face limitations in addressing evaluation needs for emerging…

信息检索 · 计算机科学 2025-07-25 Jianlyu Chen , Nan Wang , Chaofan Li , Bo Wang , Shitao Xiao , Han Xiao , Hao Liao , Defu Lian , Zheng Liu

We introduce GraphicDesignBench (GDB), the first comprehensive benchmark suite designed specifically to evaluate AI models on the full breadth of professional graphic design tasks. Unlike existing benchmarks that focus on natural-image…

计算机视觉与模式识别 · 计算机科学 2026-04-08 Adrienne Deganutti , Elad Hirsch , Haonan Zhu , Jaejung Seol , Purvanshi Mehta

The surging demand for large-scale datasets in deep learning has heightened the need for effective copyright protection, given the risks of unauthorized use to data owners. Although the dataset watermark technique holds promise for auditing…

密码学与安全 · 计算机科学 2026-02-17 Xiao Ren , Xinyi Yu , Linkang Du , Min Chen , Yuanchao Shu , Zhou Su , Yunjun Gao , Zhikun Zhang

We introduce QMBench, a comprehensive benchmark designed to evaluate the capability of large language model agents in quantum materials research. This specialized benchmark assesses the model's ability to apply condensed matter physics…

Recent advances in multi-modal generative models have driven substantial improvements in image editing. However, current generative models still struggle with handling diverse and complex image editing tasks that require implicit reasoning,…

计算机视觉与模式识别 · 计算机科学 2025-11-25 Feng Han , Yibin Wang , Chenglin Li , Zheming Liang , Dianyi Wang , Yang Jiao , Zhipeng Wei , Chao Gong , Cheng Jin , Jingjing Chen , Jiaqi Wang

This paper addresses the challenges of predicting bioprocess performance, particularly in monoclonal antibody (mAb) production, where conventional statistical methods often fall short due to time-series data's complexity and high…

机器学习 · 计算机科学 2024-11-05 Ali Nik-Khorasani , Thanh Tung Khuat , Bogdan Gabrys

This paper presents DataSciBench, a comprehensive benchmark for evaluating Large Language Model (LLM) capabilities in data science. Recent related benchmarks have primarily focused on single tasks, easily obtainable ground truth, and…

计算与语言 · 计算机科学 2025-02-20 Dan Zhang , Sining Zhoubian , Min Cai , Fengzu Li , Lekang Yang , Wei Wang , Tianjiao Dong , Ziniu Hu , Jie Tang , Yisong Yue

Given a long list of anomaly detection algorithms developed in the last few decades, how do they perform with regard to (i) varying levels of supervision, (ii) different types of anomalies, and (iii) noisy and corrupted data? In this work,…

机器学习 · 计算机科学 2022-09-20 Songqiao Han , Xiyang Hu , Hailiang Huang , Mingqi Jiang , Yue Zhao

Bayesian optimization is a powerful method for automating tuning of compilers. The complex landscape of autotuning provides a myriad of rarely considered structural challenges for black-box optimizers, and the lack of standardized…

机器学习 · 计算机科学 2025-04-09 Jacob O. Tørring , Carl Hvarfner , Luigi Nardi , Magnus Själander