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In this paper we introduce a new mathematical model for the active contraction of cardiac muscle, featuring different thermo-electric and nonlinear conductivity properties. The passive hyperelastic response of the tissue is described by an…

组织与器官 · 定量生物学 2019-05-02 Ricardo Ruiz Baier , Alessio Gizzi , Alessandro Loppini , Christian Cherubini , Simonetta Filippi

Contractile biopolymer networks, such as the actomyosin meshwork of animal cells, are ubiquitous in living organisms. The active gel theory, which provides the thermodynamic framework for these materials, has been mostly used in conjunction…

软凝聚态物质 · 物理学 2025-01-13 Antoine Jallon , Pierre Recho , Jocelyn Étienne

Bundles of filaments and motors are central to contractility in cells. The classic example is striated muscle, where actomyosin contractility is mediated by highly organized sarcomeres which act as fundamental contractile units. However,…

生物物理 · 物理学 2012-06-12 Martin Lenz , Todd Thoresen , Margaret L. Gardel , Aaron R. Dinner

Interactions between a protein and a ligand are often accompanied by a redistribution of the population of thermally accessible conformations. This dynamic response of the protein's functional energy landscape enables a protein to modulate…

生物物理 · 物理学 2016-03-15 Prithviraj Nandigrami , John J. Portman

In this study, critical behavior of low dimensional magnetic systems as cyano-bridged Tb(III)-Cr(III) bimetallic assembly was investigated with the mixed spin $3$- spin $3/2$ Ising model. The mixed spin Ising model is simulated with…

计算物理 · 物理学 2016-04-04 Aycan Özkan , Bülent Kutlu

The actin cortex is an active biopolymer network underneath the plasma membrane at the periphery of mammalian cells. It is a major regulator of cell shape through the generation of active cortical tension. In addition, the cortex…

Intermediate filaments form an essential structural network, spread throughout the cytoplasm and play a key role in cell mechanics, intracellular organization and molecular signaling. The maintenance of the network and its adaptation to the…

亚细胞过程 · 定量生物学 2023-06-14 Youngmin Park , Cécile Leduc , Sandrine Etienne-Manneville , Stéphanie Portet

Motor proteins drive persistent motion and self-organisation of cytoskeletal filaments. However, state-of-the-art microscopy techniques and continuum modelling approaches focus on large length and time scales. Here, we perform…

软凝聚态物质 · 物理学 2024-06-03 Gerrit Vliegenthart , Arvind Ravichandran , Marisol Ripoll , Thorsten Auth , Gerhard Gompper

Biological systems are among the most challenging subjects for theoretical physicists, as well as experimentalists or simulationists. Physical principles should have been both constraints and guide-lines for the evolution of living systems…

生物物理 · 物理学 2007-05-23 Ken Sekimoto , Hatsumi Nakazawa

The relaxational behaviour of the bond-diluted two-dimensional Ising model below the percolation threshold is studied using Monte Carlo techniques. The non-equilibrium decay of the magnetization,M(t), and the relaxation of the equilibrium…

凝聚态物理 · 物理学 2015-06-25 S. Jain

Collective electronic fluctuations in correlated materials give rise to various important phenomena, such as existence of the charge ordering, superconductivity, Mott insulating and magnetic phases, plasmon and magnon modes, and other…

强关联电子 · 物理学 2019-03-19 E. A. Stepanov , A. Huber , A. I. Lichtenstein , M. I. Katsnelson

We present a simple model for the bidirectional dynamics of actin bundles with alternating polarities in gliding assays with non-processive myosin motors. In the model, the bundle is represented as an elastic chain consisting of monomers…

软凝聚态物质 · 物理学 2015-05-19 Barak Gur , Oded Farago

Active force generation by actin-myosin cortex coupled to the cell membrane allows the cell to deform, respond to the environment, and mediate cell motility and division. Several membrane-bound activator proteins move along it and couple to…

软凝聚态物质 · 物理学 2021-12-23 Subhadip Ghosh , Sashideep Gutti , Debasish Chaudhuri

Muscles sense internally generated and externally applied forces, responding to these in a coordinated hierarchical manner at different time scales. The center of the basic unit of the muscle, the sarcomeric M-band, is perfectly placed to…

组织与器官 · 定量生物学 2021-09-22 Neil Ibata , Eugene M. Terentjev

The essential features of the in vitro refolding of myoglobin are expressed in a solvable physical model. Alpha helices are taken as the fundamental collective coordinates of the system, while the refolding is assumed to be mainly driven by…

凝聚态物理 · 物理学 2007-05-23 David J. E. Callaway

The actin cytoskeleton is an active semi-flexible polymer network whose non-equilibrium properties coordinate both stable and contractile behaviors to maintain or change cell shape. While myosin motors drive the actin cytoskeleton…

Using Monte Carlo simulations, we have studied isothermal aging of three-dimensional Ising spin-glass model focusing on quasi-equilibrium behavior of the spin auto-correlation function. Weak violation of the time translational invariance in…

无序系统与神经网络 · 物理学 2009-10-31 Tatsuo Komori , Hajime Yoshino , Hajime Takayama

In multicellular systems, adhesion complexes, such as those composed of E-cadherin and associated catenins, mechanically couple neighboring cells by directly linking their actin-based cytoskeletal assemblies. However, the mechanics of how…

生物物理 · 物理学 2025-09-18 XinXin Du , Ido Lavi , Michael J. Shelley

Composites of flexible and rigid polymers are ubiquitous in biology and industry alike, yet the physical principles determining their mechanical properties are far from understood. Here, we couple force spectroscopy with large-scale…

We present a neuronal network model inspired by the Ising model, where each neuron is a binary spin ($s_i = \pm1$) interacting with its neighbors on a 2D lattice. Updates are asynchronous and follow Metropolis dynamics, with a…

神经元与认知 · 定量生物学 2025-06-10 Sajedeh Sarmastani , Maliheh Ghodrat , Yousef Jamali