相关论文: Rupture-Repair Cycles in Regenerating Hydra Tissue…
Understanding how the collective physical processes drive robust morphological transitions in animal development requires the characterization of the relevant fields underlying morphogenesis. Calcium (Ca2+) is known to be such a field. Here…
These notes address the mechanics of propagating hydraulic fractures (HF). In the first part, we focus on how different physical mechanisms (dissipation in fluid and solid, fluid storage in fracture and its exchange with permeable rock,…
Epithelial tissues are continuously exposed to cyclic stretch. Physiological stretching has been found to regulate soft tissue function at the molecular, cellular, and tissue scales, allowing tissues to preserve their homeostasis and adapt…
Characterizing the interaction between water and microscopic defects is one of the long-standing challenges in understanding a broad range of cracking processes. Different physical aspects of microscopic events, driven or influenced by…
Cell division and death can be regulated by the mechanical forces within a tissue. We study the consequences for the stability and roughness of a propagating interface, by analysing a model of mechanically-regulated tissue growth in the…
Morphogenesis involves the dynamic interplay of biochemical, mechanical and electrical processes. Here we ask: to what extent can the course of morphogenesis be modulated and controlled by an external electric field? We show that above a…
We utilize whole-body Hydra regeneration from a small tissue segment to develop a physics framework for animal morphogenesis. Introducing experimental controls over this process, an external electric field and a drug that blocks gap…
This paper investigates hydraulic fracture in a media with periodic heterogeneous toughness. Results for the plane-strain (KGD) model are analysed. The energy distribution as the fracture propagates is examined, along with the evolution of…
While of paramount importance in material science, the dynamics of cracks still lacks a complete physical explanation. The transition from their slow creep behavior to a fast propagation regime is a notable key, as it leads to full material…
We detail the energy balance of a propagating hydraulic fracture. Using the linear hydraulic fracture model which combines lubrication flow and linear elastic fracture mechanics, we demonstrate how different propagation regimes are related…
Tissue organization plays a crucial role in morphogenesis, wound healing and cancer metastasis. Hydra, known for its regenerative capabilities, serves as an excellent model for studying cellular structures, particularly in pattern formation…
During hydraulic fracturing, the injection of a pressurized fluid in a brittle elastic medium leads to the formation and growth of fluid-filled fractures. A disc-like or penny-shaped fracture grows radially from a point source during the…
Hydrogels have had a profound impact in the fields of tissue engineering, drug delivery, and materials science as a whole. Due to the network architecture of these materials, imbibement with water often results in uniform swelling and…
Recent experimental investigations into Hydra regeneration revealed a remarkable phenomenon: the morphological transformation of a tissue fragment from the incipient spherical configuration to a tube-like structure - the hallmark of a…
We consider a variation of Griffith's analysis of rupture, one which simulates the process of hydrofracturing, where fluid forced into a crack raises the fluid pressure until the crack begins to grow. Unlike that of Griffith, in this…
Surface roughness emerges naturally during mechanical removal of material, fracture, chemical deposition, plastic deformation, indentation, and other processes. Here, we use continuum simulations to show how roughness which is neither…
Highly-deformable materials, from synthetic hydrogels to biological tissues, are becoming increasingly important from both fundamental and practical perspectives. Their mechanical behaviors, in particular the dynamics of crack propagation…
We studied regenerating bilayered tissue toroids dissected from Hydra vulgaris polyps and relate our macroscopic observations to the dynamics of force-generating mesoscopic cytoskeletal structures. Tissue fragments undergo a specific…
Activity and renewability are distinctive features of living matter, and constitute a new class of materials that we term renewable active matter. A striking example is the cell cytoskeleton, where myosin filaments bind to the actin…
Autocatalytic processes underlie diverse systems in which replication is triggered at interfaces, including heterogeneous catalysis on solid substrates, enzyme activity at membranes, viral infections, biofilm growth, and spatially…