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Alzheimer's Disease (AD) ravages the cognitive ability of more than 5 million Americans and creates an enormous strain on the health care system. This paper proposes a machine learning predictive model for AD development without medical…

定量方法 · 定量生物学 2020-06-17 Courtney Cochrane , David Castineira , Nisreen Shiban , Pavlos Protopapas

Alzheimer's disease (AD) poses significant global health challenges due to its increasing prevalence and associated societal costs. Early detection and diagnosis of AD are critical for delaying progression and improving patient outcomes.…

计算机视觉与模式识别 · 计算机科学 2026-02-16 Arianna Francesconi , Lazzaro di Biase , Donato Cappetta , Fabio Rebecchi , Paolo Soda , Rosa Sicilia , Valerio Guarrasi

Brain-related research topics in artificial intelligence have recently gained popularity, particularly due to the expansion of what multimodal architectures can do from computer vision to natural language processing. Our main goal in this…

神经元与认知 · 定量生物学 2024-10-01 Youssef Hmamouche , Ismail Chihab , Lahoucine Kdouri , Amal El Fallah Seghrouchni

Machine learning methods have shown large potential for the automatic early diagnosis of Alzheimer's Disease (AD). However, some machine learning methods based on imaging data have poor interpretability because it is usually unclear how…

In the field of Alzheimer's disease diagnosis, segmentation and classification tasks are inherently interconnected. Sharing knowledge between models for these tasks can significantly improve training efficiency, particularly when training…

图像与视频处理 · 电气工程与系统科学 2024-09-13 Ke Chen , Yifeng Wang , Yufei Zhou , Haohan Wang

Neurodegeneration as measured through magnetic resonance imaging (MRI) is recognized as a potential biomarker for diagnosing Alzheimer's disease (AD), but is generally considered less specific than amyloid or tau based biomarkers. Due to a…

计算机视觉与模式识别 · 计算机科学 2024-08-06 Rosemary He , Gabriella Ang , Daniel Tward

Neuropsychiatric disorders, such as Alzheimer's disease (AD), depression, and autism spectrum disorder (ASD), are characterized by linguistic and acoustic abnormalities, offering potential biomarkers for early detection. Despite the promise…

计算与语言 · 计算机科学 2025-12-25 Zhongren Dong , Haotian Guo , Weixiang Xu , Huan Zhao , Zixing Zhang

Alzheimer's disease (AD), defined as an abnormal buildup of amyloid plaques and tau tangles in the brain can be diagnosed with high accuracy based on protein biomarkers via PET or CSF analysis. However, due to the invasive nature of…

机器学习 · 计算机科学 2026-01-27 Megan A. Witherow , Michael L. Evans , Ahmed Temtam , Hamid R. Okhravi , Khan M. Iftekharuddin

Alzheimer's Disease (AD) is a progressive disease preceded by Mild Cognitive Impairment (MCI). Early detection of AD is crucial for making treatment decisions. However, most of the literature on computer-assisted detection of AD focuses on…

图像与视频处理 · 电气工程与系统科学 2023-09-15 Misgina Tsighe Hagos , Niamh Belton , Ronan P. Killeen , Kathleen M. Curran , Brian Mac Namee

Effective and accurate diagnosis of Alzheimer's disease (AD) or mild cognitive impairment (MCI) can be critical for early treatment and thus has attracted more and more attention nowadays. Since first introduced, machine learning methods…

计算机视觉与模式识别 · 计算机科学 2014-04-29 Fayao Liu , Chunhua Shen

Alzheimer's Disease (AD) is an irreversible neurodegenerative disease affecting 50 million people worldwide. Low-cost, accurate identification of key markers of AD is crucial for timely diagnosis and intervention. Language impairment is one…

计算与语言 · 计算机科学 2025-05-27 Tingyu Mo , Jacqueline C. K. Lam , Victor O. K. Li , Lawrence Y. L. Cheung

Synthesizing amyloid PET scans from the more widely available and accessible structural MRI modality offers a promising, cost-effective approach for large-scale Alzheimer's Disease (AD) screening. This is motivated by evidence that, while…

图像与视频处理 · 电气工程与系统科学 2025-11-12 Alec Sargood , Lemuel Puglisi , James H. Cole , Neil P. Oxtoby , Daniele Ravì , Daniel C. Alexander

Retinal optical coherence tomography (OCT) images are the biomarkers for neurodegenerative diseases, which are rising in prevalence. Early detection of Alzheimer's disease using retinal OCT is a primary challenging task. This work utilizes…

图像与视频处理 · 电气工程与系统科学 2025-08-19 Siva Manohar Reddy Kesu , Neelam Sinha , Hariharan Ramasangu , Thomas Gregor Issac

Owing to its pristine soft-tissue contrast and high resolution, structural magnetic resonance imaging (MRI) is widely applied in neurology, making it a valuable data source for image-based machine learning (ML) and deep learning…

图像与视频处理 · 电气工程与系统科学 2021-11-18 Merel Kuijs , Catherine R. Jutzeler , Bastian Rieck , Sarah C. Brüningk

In recent years, deep learning models have been applied to neuroimaging data for early diagnosis of Alzheimer's disease (AD). Structural magnetic resonance imaging (sMRI) and positron emission tomography (PET) images provide structural and…

图像与视频处理 · 电气工程与系统科学 2023-08-01 Yanteng Zhanga , Xiaohai He , Yi Hao Chan , Qizhi Teng , Jagath C. Rajapakse

Brain transcriptomics provides insights into the molecular mechanisms by which the brain coordinates its functions and processes. However, existing multimodal methods for predicting Alzheimer's disease (AD) primarily rely on imaging and…

人工智能 · 计算机科学 2025-04-03 Shan Cong , Zhoujie Fan , Hongwei Liu , Yinghan Zhang , Xin Wang , Haoran Luo , Xiaohui Yao

Speech pauses, alongside content and structure, offer a valuable and non-invasive biomarker for detecting dementia. This work investigates the use of pause-enriched transcripts in transformer-based language models to differentiate the…

音频与语音处理 · 电气工程与系统科学 2024-08-28 Franziska Braun , Sebastian P. Bayerl , Florian Hönig , Hartmut Lehfeld , Thomas Hillemacher , Tobias Bocklet , Korbinian Riedhammer

Estimated brain age from magnetic resonance image (MRI) and its deviation from chronological age can provide early insights into potential neurodegenerative diseases, supporting early detection and implementation of prevention strategies.…

Introduction: We present a screening method for early dementia using features based on sound objects as voice biomarkers. Methods: The final dataset used for machine learning models consisted of 266 observations, with a distribution of 186…

High-dimensional structural MRI (sMRI) images are widely used for Alzheimer's Disease (AD) diagnosis. Most existing methods for sMRI representation learning rely on 3D architectures (e.g., 3D CNNs), slice-wise feature extraction with late…

计算机视觉与模式识别 · 计算机科学 2026-01-30 Dexuan Ding , Ciyuan Peng , Endrowednes Kuantama , Jingcai Guo , Jia Wu , Jian Yang , Amin Beheshti , Ming-Hsuan Yang , Yuankai Qi
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