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We propose a scalable, provably accurate method for localizing an unknown number of multiple axis-aligned anomalous patches in spatial data under a general class of spatial dependence. Motivated by the practical need to detect localized…

统计方法学 · 统计学 2026-03-31 Soham Bonnerjee , Sayar Karmakar , George Michailidis

Whole-slide image classification represents a key challenge in computational pathology and medicine. Attention-based multiple instance learning (MIL) has emerged as an effective approach for this problem. However, the effect of attention…

In semantic segmentation, the creation of pixel-level labels for training data incurs significant costs. To address this problem, semi-supervised learning, which utilizes a small number of labeled images alongside unlabeled images to…

计算机视觉与模式识别 · 计算机科学 2026-04-09 Takahiro Mano , Reiji Saito , Kazuhiro Hotta

Whole slide image (WSI) analysis heavily relies on multiple instance learning (MIL). While recent methods benefit from large-scale foundation models and advanced sequence modeling to capture long-range dependencies, they still struggle with…

图像与视频处理 · 电气工程与系统科学 2026-03-23 Lubin Gan , Jing Zhang , Heng Zhang , Xin Di , Zhifeng Wang , Wenke Huang , Xiaoyan Sun

In computational pathology, multiple instance learning (MIL) is widely used to circumvent the computational impasse in giga-pixel whole slide image (WSI) analysis. It usually consists of two stages: patch-level feature extraction and…

图像与视频处理 · 电气工程与系统科学 2023-09-21 Beidi Zhao , Wenlong Deng , Zi Han , Li , Chen Zhou , Zuhua Gao , Gang Wang , Xiaoxiao Li

Images suffer from heavy spatial redundancy because pixels in neighboring regions are spatially correlated. Existing approaches strive to overcome this limitation by reducing less meaningful image regions. However, current leading methods…

计算机视觉与模式识别 · 计算机科学 2024-04-26 Yang Luo , Zhineng Chen , Peng Zhou , Zuxuan Wu , Xieping Gao , Yu-Gang Jiang

Lesion appearance is a crucial clue for medical providers to distinguish referable diabetic retinopathy (rDR) from non-referable DR. Most existing large-scale DR datasets contain only image-level labels rather than pixel-based annotations.…

图像与视频处理 · 电气工程与系统科学 2022-10-13 Wenhui Zhu , Peijie Qiu , Natasha Lepore , Oana M. Dumitrascu , Yalin Wang

Whole slide image (WSI) refers to a type of high-resolution scanned tissue image, which is extensively employed in computer-assisted diagnosis (CAD). The extremely high resolution and limited availability of region-level annotations make…

计算机视觉与模式识别 · 计算机科学 2023-09-06 Ruijie Zhang , Qiaozhe Zhang , Yingzhuang Liu , Hao Xin , Yan Liu , Xinggang Wang

Analysis of histopathology slides is a critical step for many diagnoses, and in particular in oncology where it defines the gold standard. In the case of digital histopathological analysis, highly trained pathologists must review vast…

计算机视觉与模式识别 · 计算机科学 2020-02-21 Pierre Courtiol , Eric W. Tramel , Marc Sanselme , Gilles Wainrib

We propose Spatial-Aware Correlated Multiple Instance Learning (SAC-MIL) for performing WSI classification. SAC-MIL consists of a positional encoding module to encode position information and a SAC block to perform full instance…

计算机视觉与模式识别 · 计算机科学 2025-09-05 Yu Bai , Zitong Yu , Haowen Tian , Xijing Wang , Shuo Yan , Lin Wang , Honglin Li , Xitong Ling , Bo Zhang , Zheng Zhang , Wufan Wang , Hui Gao , Xiangyang Gong , Wendong Wang

The deep neural network is a research hotspot for histopathological image analysis, which can improve the efficiency and accuracy of diagnosis for pathologists or be used for disease screening. The whole slide pathological image can reach…

图像与视频处理 · 电气工程与系统科学 2022-05-09 Tingting Zheng , Weixing chen , Shuqin Li , Hao Quan , Qun Bai , Tianhang Nan , Song Zheng , Xinghua Gao , Yue Zhao , Xiaoyu Cui

Learning-based image reconstruction models, such as those based on the U-Net, require a large set of labeled images if good generalization is to be guaranteed. In some imaging domains, however, labeled data with pixel- or voxel-level label…

图像与视频处理 · 电气工程与系统科学 2024-01-08 Sean I. Young , Adrian V. Dalca , Enzo Ferrante , Polina Golland , Christopher A. Metzler , Bruce Fischl , Juan Eugenio Iglesias

Semi-supervised learning methods have been explored in medical image segmentation tasks due to the scarcity of pixel-level annotation in the real scenario. Proto-type alignment based consistency constraint is an intuitional and plausible…

图像与视频处理 · 电气工程与系统科学 2022-06-07 Zhenxi Zhang , Chunna Tian , Zhicheng Jiao

Scene labeling task is to segment the image into meaningful regions and categorize them into classes of objects which comprised the image. Commonly used methods typically find the local features for each segment and label them using…

计算机视觉与模式识别 · 计算机科学 2016-08-19 Nasim Souly , Mubarak Shah

Deep convolutional neural networks have achieved remarkable progress on a variety of medical image computing tasks. A common problem when applying supervised deep learning methods to medical images is the lack of labeled data, which is very…

计算机视觉与模式识别 · 计算机科学 2020-05-12 Xiaomeng Li , Lequan Yu , Hao Chen , Chi-Wing Fu , Lei Xing , Pheng-Ann Heng

Multi-Instance Learning (MIL) has shown impressive performance for histopathology whole slide image (WSI) analysis using bags or pseudo-bags. It involves instance sampling, feature representation, and decision-making. However, existing…

计算机视觉与模式识别 · 计算机科学 2024-03-14 Tingting Zheng , Kui Jiang , Hongxun Yao

Image classification is a challenging problem for computer in reality. Large numbers of methods can achieve satisfying performances with sufficient labeled images. However, labeled images are still highly limited for certain image…

计算机视觉与模式识别 · 计算机科学 2020-11-12 Hongfeng Li

Whole Slide Image (WSI) classification relies on Multiple Instance Learning (MIL) with spatial patch features, yet existing methods struggle to capture global dependencies due to the immense size of WSIs and the local nature of patch…

计算机视觉与模式识别 · 计算机科学 2025-10-22 Anthony Bilic , Guangyu Sun , Ming Li , Md Sanzid Bin Hossain , Yu Tian , Wei Zhang , Laura Brattain , Dexter Hadley , Chen Chen

Computer-aided Whole Slide Image (WSI) classification has the potential to enhance the accuracy and efficiency of clinical pathological diagnosis. It is commonly formulated as a Multiple Instance Learning (MIL) problem, where each WSI is…

计算机视觉与模式识别 · 计算机科学 2025-04-17 Linhao Qu , Shiman Li , Xiaoyuan Luo , Shaolei Liu , Qinhao Guo , Manning Wang , Zhijian Song

Segmentation is a critical task in computational pathology, as it identifies areas affected by disease or abnormal growth and is essential for diagnosis and treatment. However, acquiring high-quality pixel-level supervised segmentation data…

计算机视觉与模式识别 · 计算机科学 2026-05-07 Zhiling Yan , Sicheng Chen , Tianyi Zhang , Nan Ying , Yanli Lei , Guanglei Zhang