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Virtual staining of histopathology images (e.g., H&E-IHC) is an emerging tool in digital pathology, enabling faster and cheaper workflows by synthesizing target stains from routinely acquired slides. Yet, the quality of virtual staining…

Histological Tertiary Lymphoid Structures (TLSs) are increasingly recognized for their correlation with the efficacy of immunotherapy in various solid tumors. Traditionally, the identification and characterization of TLSs rely on…

图像与视频处理 · 电气工程与系统科学 2024-08-27 Qiuli Wang , Yongxu Liu , Li Ma , Xianqi Wang , Wei Chen , Xiaohong Yao

We present our novel deep multi-task learning method for medical image segmentation. Existing multi-task methods demand ground truth annotations for both the primary and auxiliary tasks. Contrary to it, we propose to generate the…

图像与视频处理 · 电气工程与系统科学 2022-04-06 Binod Bhattarai , Ronast Subedi , Rebati Raman Gaire , Eduard Vazquez , Danail Stoyanov

Pathological diagnosis relies on the visual inspection of histologically stained thin tissue specimens, where different types of stains are applied to bring contrast to and highlight various desired histological features. However, the…

医学物理 · 物理学 2022-08-18 Xilin Yang , Bijie Bai , Yijie Zhang , Yuzhu Li , Kevin de Haan , Tairan Liu , Aydogan Ozcan

Recent advances in multi-modal AI have demonstrated promising potential for generating the currently expensive spatial transcriptomics (ST) data directly from routine histology images, offering a means to reduce the high cost and…

计算机视觉与模式识别 · 计算机科学 2025-08-21 Junchao Zhu , Ruining Deng , Junlin Guo , Tianyuan Yao , Juming Xiong , Chongyu Qu , Mengmeng Yin , Yu Wang , Shilin Zhao , Haichun Yang , Daguang Xu , Yucheng Tang , Yuankai Huo

We present the Hue-Net - a novel Deep Learning framework for Intensity-based Image-to-Image Translation. The key idea is a new technique termed network augmentation which allows a differentiable construction of intensity histograms from…

计算机视觉与模式识别 · 计算机科学 2019-12-13 Mor Avi-Aharon , Assaf Arbelle , Tammy Riklin Raviv

Foundation models trained with self-supervised learning (SSL) on large-scale histological images have significantly accelerated the development of computational pathology. These models can serve as backbones for region-of-interest (ROI)…

计算机视觉与模式识别 · 计算机科学 2026-02-05 Jiawen Li , Jiali Hu , Xitong Ling , Yongqiang Lv , Yuxuan Chen , Yizhi Wang , Tian Guan , Yifei Liu , Yonghong He

We present a self-supervised algorithm for several classification tasks within hematoxylin and eosin (H&E) stained images of breast cancer. Our method is robust to stain variations inherent to the histology images acquisition process, which…

计算机视觉与模式识别 · 计算机科学 2023-09-08 Alexandre Tiard , Alex Wong , David Joon Ho , Yangchao Wu , Eliram Nof , Alvin C. Goh , Stefano Soatto , Saad Nadeem

Histological staining is the gold standard for tissue examination in clinical pathology and life-science research, which visualizes the tissue and cellular structures using chromatic dyes or fluorescence labels to aid the microscopic…

医学物理 · 物理学 2023-03-07 Bijie Bai , Xilin Yang , Yuzhu Li , Yijie Zhang , Nir Pillar , Aydogan Ozcan

High-speed, high-resolution stereoscopic (H2-Stereo) video allows us to perceive dynamic 3D content at fine granularity. The acquisition of H2-Stereo video, however, remains challenging with commodity cameras. Existing spatial…

计算机视觉与模式识别 · 计算机科学 2022-08-05 Ming Cheng , Yiling Xu , Wang Shen , M. Salman Asif , Chao Ma , Jun Sun , Zhan Ma

Immunohistochemistry (IHC) has transformed clinical pathology by enabling the visualization of specific proteins within tissue sections. However, traditional IHC requires one tissue section per stain, exhibits section-to-section…

The current standard for detecting human epidermal growth factor receptor 2 (HER2) status in breast cancer patients relies on HER2 amplification, identified through fluorescence in situ hybridization (FISH) or immunohistochemistry (IHC).…

图像与视频处理 · 电气工程与系统科学 2024-09-27 Ardhendu Sekhar , Vrinda Goel , Garima Jain , Abhijeet Patil , Ravi Kant Gupta , Tripti Bameta , Swapnil Rane , Amit Sethi

Low-light image enhancement aims to restore the visibility of images captured by visual sensors in dim environments by addressing their inherent signal degradations, such as luminance attenuation and structural corruption. Although numerous…

计算机视觉与模式识别 · 计算机科学 2026-03-18 Yicui Shi , Yuhan Chen , Xiangfei Huang , Zhenguo Wang , Wenxuan Yu , Ying Fang

Estimating over-amplification of human epidermal growth factor receptor 2 (HER2) on invasive breast cancer (BC) is regarded as a significant predictive and prognostic marker. We propose a novel deep reinforcement learning (DRL) based model…

计算机视觉与模式识别 · 计算机科学 2019-03-27 Talha Qaiser , Nasir M. Rajpoot

Breast cancer, the most common malignancy among women, requires precise detection and classification for effective treatment. Immunohistochemistry (IHC) biomarkers like HER2, ER, and PR are critical for identifying breast cancer subtypes.…

计算机视觉与模式识别 · 计算机科学 2025-03-31 Ekansh Chauhan , Anila Sharma , Amit Sharma , Vikas Nishadham , Asha Ghughtyal , Ankur Kumar , Gurudutt Gupta , Anurag Mehta , C. V. Jawahar , P. K. Vinod

Histopathological cancer diagnostics has become more complex, and the increasing number of biopsies is a challenge for most pathology laboratories. Thus, development of automatic methods for evaluation of histopathological cancer sections…

图像与视频处理 · 电气工程与系统科学 2021-12-08 André Pedersen , Erik Smistad , Tor V. Rise , Vibeke G. Dale , Henrik S. Pettersen , Tor-Arne S. Nordmo , David Bouget , Ingerid Reinertsen , Marit Valla

We propose a virtual staining methodology based on Generative Adversarial Networks to map histopathology images of breast cancer tissue from H&E stain to PHH3 and vice versa. We use the resulting synthetic images to build Convolutional…

图像与视频处理 · 电气工程与系统科学 2020-03-18 Caner Mercan , Germonda Reijnen-Mooij , David Tellez Martin , Johannes Lotz , Nick Weiss , Marcel van Gerven , Francesco Ciompi

Spiking neural networks (SNNs) have garnered significant attention for their low power consumption and high biological interpretability. Their rich spatio-temporal information processing capability and event-driven nature make them ideally…

计算机视觉与模式识别 · 计算机科学 2024-09-20 Xian Zhong , Shengwang Hu , Wenxuan Liu , Wenxin Huang , Jianhao Ding , Zhaofei Yu , Tiejun Huang

Histological staining is a vital step used to diagnose various diseases and has been used for more than a century to provide contrast to tissue sections, rendering the tissue constituents visible for microscopic analysis by medical experts.…

图像与视频处理 · 电气工程与系统科学 2020-05-08 Yijie Zhang , Kevin de Haan , Yair Rivenson , Jingxi Li , Apostolos Delis , Aydogan Ozcan

Text information including extensive prior knowledge about land cover classes has been ignored in hyperspectral image classification (HSI) tasks. It is necessary to explore the effectiveness of linguistic mode in assisting HSI…

计算机视觉与模式识别 · 计算机科学 2023-02-08 Yuxiang Zhang , Mengmeng Zhang , Wei Li , Shuai Wang , Ran Tao