相关论文: Repurposing Protein Language Models for Latent Flo…

In the instruction fine-tuning of large language models (LLMs), it is widely recognized that a few high-quality instructions are superior to a large number of low-quality instructions. At present, many instruction selection methods have…

This paper presents a two-phase protein folding optimization on a three-dimensional AB off-lattice model. The first phase is responsible for forming conformations with a good hydrophobic core or a set of compact hydrophobic amino acid…

Covering all languages with a multilingual speech recognition model (MASR) is very difficult. Performing language extension on top of an existing MASR is a desirable choice. In this study, the MASR continual learning problem is…

It is crucial for large language models (LLMs) to follow instructions that involve multiple constraints. However, it is an unexplored area to enhance LLMs' ability to follow soft constraints. To bridge the gap, we initially design a…

This paper introduces diffusion protein language model (DPLM), a versatile protein language model that demonstrates strong generative and predictive capabilities for protein sequences. We first pre-train scalable DPLMs from…

Recent Vision-Language Pretrained (VLP) models have become the backbone for many downstream tasks, but they are utilized as frozen model without learning. Prompt learning is a method to improve the pre-trained VLP model by adding a…

Recent works on deep non-linear spatially selective filters demonstrate exceptional enhancement performance with computationally lightweight architectures for stationary speakers of known directions. However, to maintain this performance in…

Temporal abstraction and efficient planning pose significant challenges in offline reinforcement learning, mainly when dealing with domains that involve temporally extended tasks and delayed sparse rewards. Existing methods typically plan…

Foundation models have demonstrated remarkable performance across modalities such as language and vision. However, model reuse across distinct modalities (e.g., text and vision) remains limited due to the difficulty of aligning internal…

Designing proteins with desired functions or properties represents a core goal in synthetic biology and drug discovery. Recent advances in protein language models (PLMs) have enabled the generation of highly designable protein sequences,…

The capabilities of Large Language Models (LLMs) are limited to some extent by pre-training, so some researchers optimize LLMs through post-training. Existing post-training strategies, such as memory-based retrieval or preference…

Speech enhancement (SE) based on diffusion probabilistic models has exhibited impressive performance, while requiring a relatively high number of function evaluations (NFE). Recently, SE based on flow matching has been proposed, which…

Parameter-efficient tuning (PET) methods fit pre-trained language models (PLMs) to downstream tasks by either computing a small compressed update for a subset of model parameters, or appending and fine-tuning a small number of new model…

Deploying pretrained visual models in real-world environments often suffers from significant performance degradation due to the diversity of testing scenarios. Continuous adaptation of learning models on edge devices via unlabeled data…

Intelligent interaction with the real world requires robotic agents to jointly reason over high-level plans and low-level controls. Task and motion planning (TAMP) addresses this by combining symbolic planning and continuous trajectory…

Parameter-Efficient Fine-Tuning (PEFT) has become a key strategy for adapting large language models, with recent advances in sparse tuning reducing overhead by selectively updating key parameters or subsets of data. Existing approaches…

Designing novel functional proteins crucially depends on accurately modeling their fitness landscape. Given the limited availability of functional annotations from wet-lab experiments, previous methods have primarily relied on…

The challenges in feature selection, particularly in balancing model accuracy, interpretability, and computational efficiency, remain a critical issue in advancing machine learning methodologies. To address these complexities, this study…

Proteins move and deform to ensure their biological functions. Despite significant progress in protein structure prediction, approximating conformational ensembles at physiological conditions remains a fundamental open problem. This paper…

Diffusion-based generative models have achieved state-of-the-art performance for perceptual quality in speech enhancement (SE). However, their iterative nature requires numerous Neural Function Evaluations (NFEs), posing a challenge for…