相关论文: Repurposing Protein Language Models for Latent Flo…

Federated Active Learning (FAL) has emerged as a promising framework to leverage large quantities of unlabeled data across distributed clients while preserving data privacy. However, real-world deployments remain limited by high annotation…

The power of foundation models (FMs) lies in their capacity to learn highly expressive representations that can be adapted to a broad spectrum of tasks. However, these pretrained models require additional training stages to become effective…

This paper concerns applications of genetic algorithms and genetic programming to tasks for which it is difficult to find a representation that does not map to a highly complex and discontinuous fitness landscape. In such cases the standard…

The accurate sampling of protein dynamics is an ongoing challenge despite the utilization of High-Performance Computers (HPC) systems. Utilizing only "brute force" MD simulations requires an unacceptably long time to solution. Adaptive…

As opposed to scaling-up protein language models (PLMs), we seek improving performance via protein-specific optimization. Although the proportionality between the language model size and the richness of its learned representations is…

Embodied trajectories, such as the executable motion sequences of robotic manipulators, underwater vehicles, and mobile robots, are a fundamental output of embodied AI. Modern generative models often treat them as a dense, monolithic signal…

Protein-DNA interaction is critical for life activities such as replication, transcription, and splicing. Identifying protein-DNA binding residues is essential for modeling their interaction and downstream studies. However, developing…

Reward shaping is a technique in reinforcement learning that addresses the sparse-reward problem by providing more frequent and informative rewards. We introduce a self-adaptive and highly efficient reward shaping mechanism that…

Domain reweighting is an emerging research area aimed at adjusting the relative weights of different data sources to improve the effectiveness and efficiency of LLM pre-training. We show that data mixtures that perform well at smaller…

Large language models (LLMs) excel at language understanding and generation, but their enormous computational and memory requirements hinder deployment. Compression offers a potential solution to mitigate these constraints. However, most…

Test-time adaptation with pre-trained vision-language models has gained increasing attention for addressing distribution shifts during testing. Among these approaches, memory-based algorithms stand out due to their training-free nature and…

Sparsity-aware training is an effective approach for transforming large language models (LLMs) into hardware-friendly sparse patterns, thereby reducing latency and memory consumption during inference. In this paper, we propose Continuous…

Protein is linked to almost every life process. Therefore, analyzing the biological structure and property of protein sequences is critical to the exploration of life, as well as disease detection and drug discovery. Traditional protein…

Reward feedback learning (ReFL) has proven effective for aligning image generation with human preferences. However, its extension to video generation faces significant challenges. Existing video reward models rely on vision-language models…

Designing protein sequences that fold into a target 3-D structure, termed as the inverse folding problem, is central to protein engineering. However, it remains challenging due to the vast sequence space and the importance of local…

Recently, flow matching based speech synthesis has significantly enhanced the quality of synthesized speech while reducing the number of inference steps. In this paper, we introduce SlimSpeech, a lightweight and efficient speech synthesis…

Synthesizing physiologically-accurate human movement in a variety of conditions can help practitioners plan surgeries, design experiments, or prototype assistive devices in simulated environments, reducing time and costs and improving…

Large language models (LLMs) deployed on edge servers are increasingly used in latency-sensitive applications such as personalized assistants, recommendation, and content moderation. However, the non-stationary nature of user data…

Direct Preference Optimization (DPO) is an effective approach for aligning protein language models with experimental design goals. However, DPO faces a scalability bottleneck: the number of possible training pairs grows quadratically with…

Training-free conditional generation based on flow matching aims to leverage pre-trained unconditional flow matching models to perform conditional generation without retraining. Recently, a successful training-free conditional generation…