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In recent years, the integration of pre-trained foundational models with multiple instance learning (MIL) has improved diagnostic accuracy in computational pathology. However, existing MIL methods focus on optimizing feature extractors and…

计算机视觉与模式识别 · 计算机科学 2025-12-24 Le Feng , Li Xiao

Histopathological whole slide image (WSI) analysis with deep learning has become a research focus in computational pathology. The current paradigm is mainly based on multiple instance learning (MIL), in which approaches with Transformer as…

计算机视觉与模式识别 · 计算机科学 2024-03-19 Hongbo Chu , Qiehe Sun , Jiawen Li , Yuxuan Chen , Lizhong Zhang , Tian Guan , Anjia Han , Yonghong He

Graph convolutional neural networks have shown significant potential in natural and histopathology images. However, their use has only been studied in a single magnification or multi-magnification with late fusion. In order to leverage the…

计算机视觉与模式识别 · 计算机科学 2023-08-22 Roozbeh Bazargani , Ladan Fazli , Larry Goldenberg , Martin Gleave , Ali Bashashati , Septimiu Salcudean

Multiple Instance Learning (MIL) is a cornerstone approach in computational pathology (CPath) for generating clinically meaningful slide-level embeddings from gigapixel tissue images. However, MIL often struggles with small, weakly…

计算机视觉与模式识别 · 计算机科学 2025-06-12 Daniel Shao , Richard J. Chen , Andrew H. Song , Joel Runevic , Ming Y. Lu , Tong Ding , Faisal Mahmood

Accurate analysis of histopathological images is critical for disease diagnosis and treatment planning. Whole-slide images (WSIs), which digitize tissue specimens at gigapixel resolution, are fundamental to this process but require…

计算机视觉与模式识别 · 计算机科学 2026-05-07 Enhui Chai , Sicheng Chen , Tianyi Zhang , Chad Wong , Kecheng Huang , Zeyu Liu , Fei Xia

Multiple instance learning (MIL) is a key algorithm for classification of whole slide images (WSI). Histology WSIs can have billions of pixels, which create enormous computational and annotation challenges. Typically, such images are…

图像与视频处理 · 电气工程与系统科学 2021-11-03 Andriy Myronenko , Ziyue Xu , Dong Yang , Holger Roth , Daguang Xu

Whole slide images (WSIs) are gigapixel-scale digital images of H\&E-stained tissue samples widely used in pathology. The substantial size and complexity of WSIs pose unique analytical challenges. Multiple Instance Learning (MIL) has…

计算机视觉与模式识别 · 计算机科学 2024-08-20 Jun Wang , Yu Mao , Nan Guan , Chun Jason Xue

Multi-Instance Learning(MIL) aims to learn the mapping between a bag of instances and the bag-level label. Therefore, the relationships among instances are very important for learning the mapping. In this paper, we propose an MIL algorithm…

机器学习 · 计算机科学 2021-02-04 Yangling Ma , Zhouwang Yang

Multi-Instance Learning (MIL) is pivotal for analyzing complex, weakly labeled datasets, such as whole-slide images (WSIs) in computational pathology, where bags comprise unordered collections of instances with sparse diagnostic relevance.…

计算机视觉与模式识别 · 计算机科学 2025-09-16 Yuedi Zhang , Zhixiang Xia , Guosheng Yin , Bin Liu

Multiple instance learning (MIL) is the standard approach for whole-slide image (WSI) classification and survival prediction, where attention-based models ag gregate patch features into slide-level predictions. These models treat attention…

计算机视觉与模式识别 · 计算机科学 2026-05-19 Xiangyu Li , Ran Su

Whole-slide image (WSI) classification is a challenging task because 1) patches from WSI lack annotation, and 2) WSI possesses unnecessary variability, e.g., stain protocol. Recently, Multiple-Instance Learning (MIL) has made significant…

计算机视觉与模式识别 · 计算机科学 2025-08-12 Joohyung Lee , Heejeong Nam , Kwanhyung Lee , Sangchul Hahn

Whole-slide image classification represents a key challenge in computational pathology and medicine. Attention-based multiple instance learning (MIL) has emerged as an effective approach for this problem. However, the effect of attention…

Pyramidal networks are standard methods for multi-scale object detection. Current researches on feature pyramid networks usually adopt layer connections to collect features from certain levels of the feature hierarchy, and do not consider…

计算机视觉与模式识别 · 计算机科学 2022-06-17 Junliang Chen , Weizeng Lu , Linlin Shen

Whole Slide Imaging (WSI), which involves high-resolution digital scans of pathology slides, has become the gold standard for cancer diagnosis, but its gigapixel resolution and the scarcity of annotated datasets present challenges for deep…

图像与视频处理 · 电气工程与系统科学 2025-02-03 Rita Pereira , M. Rita Verdelho , Catarina Barata , Carlos Santiago

Multiple Instance Learning (MIL), a powerful strategy for weakly supervised learning, is able to perform various prediction tasks on gigapixel Whole Slide Images (WSIs). However, the tens of thousands of patches in WSIs usually incur a vast…

计算机视觉与模式识别 · 计算机科学 2023-03-14 Zhuchen Shao , Liuxi Dai , Yifeng Wang , Haoqian Wang , Yongbing Zhang

Advances in medical imaging and deep learning have propelled progress in whole slide image (WSI) analysis, with multiple instance learning (MIL) showing promise for efficient and accurate diagnostics. However, conventional MIL models often…

计算机视觉与模式识别 · 计算机科学 2025-05-19 Xianrui Li , Yufei Cui , Jun Li , Antoni B. Chan

Multiple Instance Learning (MIL) has been widely applied in pathology towards solving critical problems such as automating cancer diagnosis and grading, predicting patient prognosis, and therapy response. Deploying these models in a…

计算机视觉与模式识别 · 计算机科学 2022-10-18 Syed Ashar Javed , Dinkar Juyal , Harshith Padigela , Amaro Taylor-Weiner , Limin Yu , Aaditya Prakash

Universal lesion detection (ULD) on computed tomography (CT) images is an important but underdeveloped problem. Recently, deep learning-based approaches have been proposed for ULD, aiming to learn representative features from annotated CT…

计算机视觉与模式识别 · 计算机科学 2019-12-17 Zihao Li , Shu Zhang , Junge Zhang , Kaiqi Huang , Yizhou Wang , Yizhou Yu

Deep learning models have revolutionized the field of medical image analysis, due to their outstanding performances. However, they are sensitive to spurious correlations, often taking advantage of dataset bias to improve results for…

计算机视觉与模式识别 · 计算机科学 2024-05-06 Diogo J. Araújo , M. Rita Verdelho , Alceu Bissoto , Jacinto C. Nascimento , Carlos Santiago , Catarina Barata

Fine-grained classification of whole slide images (WSIs) is essential in precision oncology, enabling precise cancer diagnosis and personalized treatment strategies. The core of this task involves distinguishing subtle morphological…

计算机视觉与模式识别 · 计算机科学 2025-04-07 Cheng Jin , Luyang Luo , Huangjing Lin , Jun Hou , Hao Chen