相关论文: An explainable framework for the relationship betw…
Generative models such as Generative Adversarial Networks (GANs) and Variational Autoencoders (VAEs) play an increasingly important role in medical image analysis. The latent spaces of these models often show semantically meaningful…
Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects cognitive functions such as memory, thinking, and behavior. In this disease, there is a critical phase, mild cognitive impairment, that is really…
Interpretability is a critical factor in applying complex deep learning models to advance the understanding of brain disorders in neuroimaging studies. To interpret the decision process of a trained classifier, existing techniques typically…
Despite recent successes in synthesizing faces and bedrooms, existing generative models struggle to capture more complex image types, potentially due to the oversimplification of their latent space constructions. To tackle this issue,…
Lateral ventricle (LV) shape analysis holds promise as a biomarker for neurological diseases; however, challenges remain due to substantial shape variability across individuals and segmentation difficulties arising from limited MRI…
Prediction of the cognitive evolution of a person susceptible to develop a neurodegenerative disorder is crucial to provide an appropriate treatment as soon as possible. In this paper we propose a 3D siamese network designed to extract…
Event-based models (EBM) are a class of disease progression models that can be used to estimate temporal ordering of neuropathological changes from cross-sectional data. Current EBMs only handle scalar biomarkers, such as regional volumes,…
A variational autoencoder (VAE) is a probabilistic machine learning framework for posterior inference that projects an input set of high-dimensional data to a lower-dimensional, latent space. The latent space learned with a VAE offers…
Variational Autoencoder is a scalable method for learning latent variable models of complex data. It employs a clear objective that can be easily optimized. However, it does not explicitly measure the quality of learned representations. We…
Normative modeling is an emerging and promising approach to effectively study disorder heterogeneity in individual participants. In this study, we propose a novel normative modeling method by combining conditional variational autoencoder…
Lung cancer is responsible for 21% of cancer deaths in the UK and five-year survival rates are heavily influenced by the stage the cancer was identified at. Recent studies have demonstrated the capability of AI methods for accurate and…
Latent Diffusion Models (LDMs) rely heavily on the compressed latent space provided by Variational Autoencoders (VAEs) for high-quality image generation. Recent studies have attempted to obtain generation-friendly VAEs by directly adopting…
We present a probabilistic programmed deep kernel learning approach to personalized, predictive modeling of neurodegenerative diseases. Our analysis considers a spectrum of neural and symbolic machine learning approaches, which we assess…
Multi-modal biological, imaging, and neuropsychological markers have demonstrated promising performance for distinguishing Alzheimer's disease (AD) patients from cognitively normal elders. However, it remains difficult to early predict when…
We present a novel approach for the dimensionality reduction of galaxy images by leveraging a combination of variational auto-encoders (VAE) and domain adaptation (DA). We demonstrate the effectiveness of this approach using a sample of low…
Alzheimer's disease is an untreatable, progressive brain disorder that slowly robs people of their memory, thinking abilities, and ultimately their capacity to complete even the most basic tasks. Among older adults, it is the most frequent…
It is acknowledged that the most common cause of dementia worldwide is Alzheimer's disease (AD). This condition progresses in severity from mild to severe and interferes with people's everyday routines. Early diagnosis plays a critical role…
The manifold assumption for high-dimensional data assumes that the data is generated by varying a set of parameters obtained from a low-dimensional latent space. Deep generative models (DGMs) are widely used to learn data representations in…
Dementia is a neurodegenerative disorder that has been growing among elder people over the past decades. This growth profoundly impacts the quality of life for patients and caregivers due to the symptoms arising from it. Agitation and…
We develop a Bayesian bivariate spatial model for multivariate regression analysis applicable to studies examining the influence of genetic variation on brain structure. Our model is motivated by an imaging genetics study of the Alzheimer's…