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Despite the promise of computational pathology foundation models, adapting them to specific clinical tasks remains challenging due to the complexity of whole-slide image (WSI) processing, the opacity of learned features, and the wide range…

计算机视觉与模式识别 · 计算机科学 2025-11-26 Abdul Rahman Diab , Emily E. Karn , Renchin Wu , Emily S. Ruiz , William Lotter

While human observers are able to cope with variations in color and appearance of histological stains, digital pathology algorithms commonly require a well-normalized setting to achieve peak performance, especially when a limited amount of…

计算机视觉与模式识别 · 计算机科学 2017-08-15 Daniel Bug , Steffen Schneider , Anne Grote , Eva Oswald , Friedrich Feuerhake , Julia Schüler , Dorit Merhof

Computer-aided diagnosis (CAD) based on histopathological imaging has progressed rapidly in recent years with the rise of machine learning based methodologies. Traditional approaches consist of training a classification model using features…

计算机视觉与模式识别 · 计算机科学 2019-03-29 Junaid Malik , Serkan Kiranyaz , Suchitra Kunhoth , Turker Ince , Somaya Al-Maadeed , Ridha Hamila , Moncef Gabbouj

Imaging mass spectrometry (IMS) is a powerful tool for untargeted, highly multiplexed molecular mapping of tissue in biomedical research. IMS offers a means of mapping the spatial distributions of molecular species in biological tissue with…

计算机视觉与模式识别 · 计算机科学 2025-08-05 Yijie Zhang , Luzhe Huang , Nir Pillar , Yuzhu Li , Lukasz G. Migas , Raf Van de Plas , Jeffrey M. Spraggins , Aydogan Ozcan

Unsupervised and unpaired domain translation using generative adversarial neural networks, and more precisely CycleGAN, is state of the art for the stain translation of histopathology images. It often, however, suffers from the presence of…

计算机视觉与模式识别 · 计算机科学 2022-07-04 Nicolas Brieu , Felix J. Segerer , Ansh Kapil , Philipp Wortmann , Guenter Schmidt

While spatial transcriptomics (ST) has advanced our understanding of gene expression in tissue context, its high experimental cost limits its large-scale application. Predicting ST from pathology images is a promising, cost-effective…

计算机视觉与模式识别 · 计算机科学 2026-03-25 Zhiceng Shi , Changmiao Wang , Jun Wan , Wenwen Min

Most recently, the pathology diagnosis of cancer is shifting to integrating molecular makers with histology features. It is a urgent need for digital pathology methods to effectively integrate molecular markers with histology, which could…

图像与视频处理 · 电气工程与系统科学 2023-06-28 Xiaofei Wang , Stephen Price , Chao Li

Existing Masked Image Modeling (MIM) depends on a spatial patch-based masking-reconstruction strategy to perceive objects'features from unlabeled images, which may face two limitations when applied to chest CT: 1) inefficient feature…

图像与视频处理 · 电气工程与系统科学 2024-07-15 Jie Zheng , Ru Wen , Haiqin Hu , Lina Wei , Kui Su , Wei Chen , Chen Liu , Jun Wang

Virtual histology is an emerging field in biomedicine that enables three-dimensional tissue visualization using X-ray micro-computed tomography. However, the method still lacks the specificity of conventional histology, in which parts of…

Multi-modal learning plays a crucial role in cancer diagnosis and prognosis. Current deep learning based multi-modal approaches are often limited by their abilities to model the complex correlations between genomics and histology data,…

图像与视频处理 · 电气工程与系统科学 2024-06-21 Yupei Zhang , Xiaofei Wang , Fangliangzi Meng , Jin Tang , Chao Li

For diagnosing melanoma, hematoxylin and eosin (H&E) stained tissue slides remains the gold standard. These images contain quantitative information in different magnifications. In the present study, we investigated whether deep…

组织与器官 · 定量生物学 2019-04-15 Peizhen Xie , Ke Zuo , Yu Zhang , Fangfang Li , Mingzhu Yin , Kai Lu

Virtual staining is a promising technique that uses deep generative models to recreate histological stains, providing a faster and more cost-effective alternative to traditional tissue chemical staining. Specifically for H&E-HER2 staining…

图像与视频处理 · 电气工程与系统科学 2025-10-02 Pascal Klöckner , José Teixeira , Diana Montezuma , Jaime S. Cardoso , Hugo M. Horlings , Sara P. Oliveira

Textual-visual matching aims at measuring similarities between sentence descriptions and images. Most existing methods tackle this problem without effectively utilizing identity-level annotations. In this paper, we propose an identity-aware…

计算机视觉与模式识别 · 计算机科学 2017-08-08 Shuang Li , Tong Xiao , Hongsheng Li , Wei Yang , Xiaogang Wang

Numerous deep learning based methods have been developed for nuclei segmentation for H&E images and have achieved close to human performance. However, direct application of such methods to another modality of images, such as…

计算机视觉与模式识别 · 计算机科学 2022-08-15 Roger Trullo , Quoc-Anh Bui , Qi Tang , Reza Olfati-Saber

Learning medical visual representations from image-report pairs through joint learning has garnered increasing research attention due to its potential to alleviate the data scarcity problem in the medical domain. The primary challenges stem…

计算机视觉与模式识别 · 计算机科学 2025-12-09 Jun Wang , Lixing Zhu , Xiaohan Yu , Abhir Bhalerao , Yulan He

We propose a novel semi-supervised learning approach for classification of histopathology images. We employ strong supervision with patch-level annotations combined with a novel co-training loss to create a semi-supervised learning…

计算机视觉与模式识别 · 计算机科学 2022-08-30 Bodong Zhang , Beatrice Knudsen , Deepika Sirohi , Alessandro Ferrero , Tolga Tasdizen

Variability in illumination is a primary factor limiting deep learning robustness for field-based plant disease detection. This study evaluates Histogram Matching (HM), a technique that transforms the pixel intensity distribution of an…

计算机视觉与模式识别 · 计算机科学 2026-04-22 Ruben Pascual , Inés Hernández , Salvador Gutiérrez , Javier Tardaguila , Pedro Melo-Pinto , Daniel Paternain , Mikel Galar

Deep learning-based virtual staining was developed to introduce image contrast to label-free tissue sections, digitally matching the histological staining, which is time-consuming, labor-intensive, and destructive to tissue. Standard…

图像与视频处理 · 电气工程与系统科学 2022-10-31 Yijie Zhang , Luzhe Huang , Tairan Liu , Keyi Cheng , Kevin de Haan , Yuzhu Li , Bijie Bai , Aydogan Ozcan

Histopathological image analysis is an essential process for the discovery of diseases such as cancer. However, it is challenging to train CNN on whole slide images (WSIs) of gigapixel resolution considering the available memory capacity.…

图像与视频处理 · 电气工程与系统科学 2019-10-11 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Masashi Fukayama , Akihiko Yoshizawa , Masanobu Kitagawa , Tatsuya Harada

The development of reliable imaging biomarkers for the analysis of colorectal cancer (CRC) in hematoxylin and eosin (H&E) stained histopathology images requires an accurate and reproducible classification of the main tissue components in…

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