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Computational Pathology CPath is an interdisciplinary science that augments developments of computational approaches to analyze and model medical histopathology images. The main objective for CPath is to develop infrastructure and workflows…

The emergence of digital pathology has opened new horizons for histopathology and cytology. Artificial-intelligence algorithms are able to operate on digitized slides to assist pathologists with diagnostic tasks. Whereas machine learning…

Background: Clinical guidelines and recommendations are the driving wheels of the evidence-based medicine (EBM) paradigm, but these are available primarily as unstructured text and are generally highly heterogeneous in nature. This…

计算与语言 · 计算机科学 2016-09-07 Ravi P Garg , Kalpana Raja , Siddhartha R Jonnalagadda

Labelling tissue components in histology whole slide images (WSIs) is prohibitively labour-intensive: a single slide may contain tens of thousands of structures--cells, nuclei, and other morphologically distinct objects--each requiring…

定量方法 · 定量生物学 2026-04-13 Muhammad Haseeb Ahmad , Sharmila Rajendran , Damion Young , Jon Mason

Clinical Practice Guidelines (CPGs) for cancer diseases evolve rapidly due to new evidence generated by active research. Currently, CPGs are primarily published in a document format that is ill-suited for managing this developing knowledge.…

Cytology is a valuable tool for early detection of oral squamous cell carcinoma (OSCC). However, manual examination of cytology whole slide images (WSIs) is slow, subjective, and depends heavily on expert pathologists. To address this, we…

图像与视频处理 · 电气工程与系统科学 2025-11-18 Rupam Mukherjee , Rajkumar Daniel , Soujanya Hazra , Shirin Dasgupta , Subhamoy Mandal

Automated generation of diagnostic pathology reports directly from whole slide images (WSIs) is an emerging direction in computational pathology. Translating high-resolution tissue patterns into clinically coherent text remains difficult…

计算机视觉与模式识别 · 计算机科学 2025-12-16 Noorul Wahab , Nasir Rajpoot

Foundation models are reshaping computational histopathology, yet their value for whole-slide image retrieval relative to strong patch-based and supervised aggregation baselines remains unclear. We benchmarked ten pipelines on 9,387…

计算机视觉与模式识别 · 计算机科学 2026-05-05 Tianhao Lei , Parsa Esmaeilkhani , Saghir Alfasly , Wataru Uegami , Judy C. Boughey , Matthew P. Goetz , Krishna R. Kalari , H. R. Tizhoosh

Accurate symptom-to-disease classification and clinically grounded treatment recommendations remain challenging, particularly in heterogeneous patient settings with high diagnostic risk. Existing large language model (LLM)-based systems…

How can we interpret and retrieve medical evidence to support clinical decisions? Clinical trial reports (CTR) amassed over the years contain indispensable information for the development of personalized medicine. However, it is practically…

计算与语言 · 计算机科学 2023-10-31 Maël Jullien , Marco Valentino , Hannah Frost , Paul O'Regan , Donal Landers , André Freitas

Due to the large size and lack of fine-grained annotation, Whole Slide Images (WSIs) analysis is commonly approached as a Multiple Instance Learning (MIL) problem. However, previous studies only learn from training data, posing a stark…

计算机视觉与模式识别 · 计算机科学 2024-11-28 Weiqin Zhao , Ziyu Guo , Yinshuang Fan , Yuming Jiang , Maximus Yeung , Lequan Yu

Learning medical visual representations from image-report pairs through joint learning has garnered increasing research attention due to its potential to alleviate the data scarcity problem in the medical domain. The primary challenges stem…

计算机视觉与模式识别 · 计算机科学 2025-12-09 Jun Wang , Lixing Zhu , Xiaohan Yu , Abhir Bhalerao , Yulan He

An automated knowledge modeling algorithm for Cancer Clinical Practice Guidelines (CPGs) extracts the knowledge contained in the CPG documents and transforms it into a programmatically interactable, easy-to-update structured model with…

计算与语言 · 计算机科学 2024-08-01 Pralaypati Ta , Bhumika Gupta , Arihant Jain , Sneha Sree C , Keerthi Ram , Mohanasankar Sivaprakasam

Recent advances in artificial intelligence (AI), in particular self-supervised learning of foundation models (FMs), are revolutionizing medical imaging and computational pathology (CPath). A constant challenge in the analysis of digital…

Purpose: In this work, we present a collaboration to create a validation dataset of pathologist annotations for algorithms that process whole slide images (WSIs). We focus on data collection and evaluation of algorithm performance in the…

Whole slide imaging is fundamental to biomedical microscopy and computational pathology. Previously, learning representations for gigapixel-sized whole slide images (WSIs) has relied on multiple instance learning with weak labels, which do…

计算机视觉与模式识别 · 计算机科学 2024-05-27 Xinhai Hou , Cheng Jiang , Akhil Kondepudi , Yiwei Lyu , Asadur Chowdury , Honglak Lee , Todd C. Hollon

Community-based Question Answering (CQA) sites play an important role in addressing health information needs. However, a significant number of posted questions remain unanswered. Automatically answering the posted questions can provide a…

机器学习 · 统计学 2016-07-05 Papis Wongchaisuwat , Diego Klabjan , Siddhartha R. Jonnalagadda

Representation learning of pathology whole-slide images (WSIs) has primarily relied on weak supervision with Multiple Instance Learning (MIL). This approach leads to slide representations highly tailored to a specific clinical task.…

计算机视觉与模式识别 · 计算机科学 2025-03-25 Tim Lenz , Peter Neidlinger , Marta Ligero , Georg Wölflein , Marko van Treeck , Jakob Nikolas Kather

Computational pathology holds substantial promise for improving diagnosis and guiding treatment decisions. Recent pathology foundation models enable the extraction of rich patch-level representations from large-scale whole-slide images…

计算机视觉与模式识别 · 计算机科学 2025-11-20 Xiangde Luo , Jinxi Xiang , Yuanfeng Ji , Ruijiang Li

Navigating healthcare systems can be complex and overwhelming, creating barriers for patients seeking timely and appropriate medical attention. In this paper, we introduce C-PATH (Conversational Patient Assistance and Triage in Healthcare),…

计算与语言 · 计算机科学 2025-06-10 Qi Shi , Qiwei Han , Cláudia Soares