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This is a method for discrete event simulation specified by survival analysis. It presents a sequence of steps. First, hazard rates from survival analysis specify the rates of a set of counting processes. Second, those counting processes…

统计计算 · 统计学 2016-10-14 Andrew J. Dolgert

Survival analysis is crucial for many medical applications, but remains challenging for modern machine learning due to limited data, censoring, and the heterogeneity of tabular covariates. While the prior-fitted paradigm, which relies on…

机器学习 · 计算机科学 2026-05-14 Dmitrii Seletkov , Paul Hager , Georgios Kaissis , Rickmer Braren , Daniel Rueckert , Raphael Rehms

We define a new class of predicates called equilevel predicates on a distributive lattice which eases the analysis of parallel algorithms. Many combinatorial problems such as the vertex cover problem, the bipartite matching problem, and the…

分布式、并行与集群计算 · 计算机科学 2023-11-13 Vijay K. Garg , Robert P. Streit

Propensity scores are commonly used to reduce the confounding bias in non-randomized observational studies for estimating the average treatment effect. An important assumption underlying this approach is that all confounders that are…

统计方法学 · 统计学 2022-08-02 Youfei Yu , Jiacong Du , Min Zhang , Zhenke Wu , Andrew M. Ryan , Bhramar Mukherjee

Document-level Event Argument Extraction (EAE) requires the model to extract arguments of multiple events from a single document. Considering the underlying dependencies between these events, recent efforts leverage the idea of "memory",…

计算与语言 · 计算机科学 2023-10-26 Quzhe Huang , Yanxi Zhang , Dongyan Zhao

Deep generative models such as conditional variational autoencoders (CVAEs) have shown great promise for predicting trajectories of surrounding agents in autonomous vehicle planning. State-of-the-art models have achieved remarkable accuracy…

机器人学 · 计算机科学 2025-10-14 Yongxi Cao , Julian F. Schumann , Jens Kober , Joni Pajarinen , Arkady Zgonnikov

We propose TRACIE, a novel temporal reasoning dataset that evaluates the degree to which systems understand implicit events -- events that are not mentioned explicitly in natural language text but can be inferred from it. This introduces a…

计算与语言 · 计算机科学 2021-05-11 Ben Zhou , Kyle Richardson , Qiang Ning , Tushar Khot , Ashish Sabharwal , Dan Roth

The level of tumour-infiltrating lymphocytes (TILs) is a prognostic factor for patients with (triple-negative) breast cancer (BC). Computational TIL assessment (CTA) has the potential to assist pathologists in this labour-intensive task,…

We present ProbMetab, an R package which promotes substantial improvement in automatic probabilistic LC-MS based metabolome annotation. The inference engine core is based on a Bayesian model implemented to: (i) allow diverse source of…

In medicine, survival analysis studies the time duration to events of interest such as mortality. One major challenge is how to deal with multiple competing events (e.g., multiple disease diagnoses). In this work, we propose a…

机器学习 · 计算机科学 2022-06-29 Zifeng Wang , Jimeng Sun

Estimating causal effects on time-to-event outcomes from observational data is particularly challenging due to censoring, limited sample sizes, and non-random treatment assignment. The need for answering such "when-if" questions--how the…

机器学习 · 计算机科学 2025-11-19 Jessy Xinyi Han , Devavrat Shah

Modern manufacturing environments demand not only accurate predictions but also interpretable insights to process anomalies, root causes, and potential interventions. Existing AI systems often function as isolated black boxes, lacking the…

This study introduces a novel methodology for modelling patient emotions from online patient experience narratives. We employed metadata network topic modelling to analyse patient-reported experiences from Care Opinion, revealing key…

计算与语言 · 计算机科学 2024-01-10 Curtis Murray , Lewis Mitchell , Jonathan Tuke , Mark Mackay

Tabular biomedical data poses challenges in machine learning because it is often high-dimensional and typically low-sample-size (HDLSS). Previous research has attempted to address these challenges via local feature selection, but existing…

机器学习 · 计算机科学 2024-06-04 Xiangjian Jiang , Andrei Margeloiu , Nikola Simidjievski , Mateja Jamnik

Precision medicine is an evolving area in the medical field and rely on biomarkers to make patient enrichment decisions, thereby providing drug development direction. A traditional statistical approach is to find the cut-off that leads to…

统计方法学 · 统计学 2025-04-14 Gina D'Angelo , Xiaowen Tian , Chuyu Deng , Xian Zhou

Surrogate endpoint (SE) for overall survival in cancer patients is essential to improving the efficiency of oncology drug development. In practice, we may discover a new patient level association with survival, based on one or more clinical…

应用统计 · 统计学 2022-11-08 Wei Zou

Heterogeneous treatment effects (HTEs) are commonly identified during randomized controlled trials (RCTs). Identifying subgroups of patients with similar treatment effects is of high interest in clinical research to advance precision…

机器学习 · 计算机科学 2022-12-06 Peniel N. Argaw , Elizabeth Healey , Isaac S. Kohane

The rapid advancements in artificial intelligence (AI) have revolutionized smart healthcare, driving innovations in wearable technologies, continuous monitoring devices, and intelligent diagnostic systems. However, security, explainability,…

机器学习 · 计算机科学 2024-10-02 Prasenjit Maji , Amit Kumar Mondal , Hemanta Kumar Mondal , Saraju P. Mohanty

With the increased availability of large databases of electronic health records (EHRs) comes the chance of enhancing health risks screening. Most post-marketing detections of adverse drug reaction (ADR) rely on physicians' spontaneous…

应用统计 · 统计学 2018-01-29 Maryan Morel , Emmanuel Bacry , Stéphane Gaïffas , Agathe Guilloux , Fanny Leroy

Medical Cyber-physical Systems (MCPS) are vulnerable to accidental or malicious faults that can target their controllers and cause safety hazards and harm to patients. This paper proposes a combined model and data-driven approach for…

人工智能 · 计算机科学 2021-04-14 Xugui Zhou , Bulbul Ahmed , James H. Aylor , Philip Asare , Homa Alemzadeh