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Quantitative magnetization transfer (qMT) imaging provides myelin-sensitive biomarkers, such as the pool size ratio (PSR), which is valuable for multiple sclerosis (MS) assessment. However, qMT requires specialized 20-30 minute scans. We…

图像与视频处理 · 电气工程与系统科学 2025-11-27 Jiacheng Wang , Hao Li , Xing Yao , Ahmad Toubasi , Taegan Vinarsky , Caroline Gheen , Joy Derwenskus , Chaoyang Jin , Richard Dortch , Junzhong Xu , Francesca Bagnato , Ipek Oguz

Quantitative magnetic resonance imaging might provide a more specific insight into disease process, progression and therapeutic response of multiple sclerosis. We present an extension of a previously published approach for the simultaneous…

Magnetic Resonance Fingerprinting (MRF) enables simultaneous mapping of multiple tissue parameters such as T1 and T2 relaxation times. The working principle of MRF relies on varying acquisition parameters pseudo-randomly, so that each…

图像与视频处理 · 电气工程与系统科学 2020-12-03 Refik Soyak , Ebru Navruz , Eda Ozgu Ersoy , Gastao Cruz , Claudia Prieto , Andrew P. King , Devrim Unay , Ilkay Oksuz

Multi-organ segmentation of 3D medical images is fundamental with meaningful applications in various clinical automation pipelines. Although deep learning has achieved superior performance, the time and memory consumption of segmenting the…

计算机视觉与模式识别 · 计算机科学 2025-11-12 Xueqi Guo , Halid Ziya Yerebakan , Yoshihisa Shinagawa , Kritika Iyer , Gerardo Hermosillo Valadez

Organ-specific, targeted Field-of-View (FoV) Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) inserts are viable solutions for a number of imaging tasks where whole-body PET/MRI systems lack the necessary sensitivity and…

仪器与探测器 · 物理学 2019-09-19 J. M. C. Brown , S. E. Brunner , D. R. Schaart

Multi-echo Gradient Echo (mGRE) sequences provide valuable quantitative parametric maps, such as Quantitative Susceptibility Mapping (QSM) and transverse relaxation rate (R2*), sensitive to tissue iron and myelin. However, structural…

图像与视频处理 · 电气工程与系统科学 2025-12-02 Sizhe Fang , Deqiang Qiu

Total-body positron emission tomography (PET) imaging has the potential to transform medical care of a number of diseases and augment our knowledge of systems biology. Various detector designs and geometries are currently under development…

Purpose: Ultra-high-field 7T MRI offers improved resolution and contrast over standard clinical field strengths (1.5T, 3T). However, 7T scanners are costly, scarce, and introduce additional challenges such as susceptibility artifacts. We…

计算机视觉与模式识别 · 计算机科学 2025-11-18 Zach Eidex , Mojtaba Safari , Tonghe Wang , Vanessa Wildman , David S. Yu , Hui Mao , Erik Middlebrooks , Aparna Kesarwala , Xiaofeng Yang

Spin-labeling of molecules with paramagnetic ions is an important approach for determining molecular structure, however current ensemble techniques lack the sensitivity to detect few isolated spins. In this Letter, we demonstrate…

介观与纳米尺度物理 · 物理学 2014-12-03 Matthew Pelliccione , Bryan A. Myers , Laetitia Pascal , Ananda Das , Ania C. Bleszynski Jayich

OBJECTIVE: This study evaluated the accuracy in localisation and distribution of real-time three-dimensional (4-D) ultrasound-guided biopsies on a prostate phantom. METHODS: A prostate phantom was created. A three-dimensional real-time…

In the framework of algebraic inversion, Magnetic Resonance Elastography (MRE) repeatability, reproducibility and robustness were evaluated on extracted shear velocities (or elastic moduli). The same excitation system was implemented at two…

Quantitative MRI enables direct quantification of contrast agent concentrations in contrast-enhanced scans. However, the lengthy scan times required by conventional methods are inadequate for tracking contrast agent transport dynamically in…

This study presents the design, simulation, and experimental validation of a dual-tuned concentric multimodal surface coil for 7T 1H/31P magnetic resonance spectroscopic imaging (MRSI), developed to significantly enhance 31P B1 efficiency…

医学物理 · 物理学 2026-01-01 Yunkun Zhao , Xiaoliang Zhang

The tumor microenvironment (TME) features distinct hallmarks, including acidosis, hypoxia, reactive oxygen species (ROS) generation, and altered ion fluxes, which are crucial targets for early cancer biomarker detection, tumor diagnosis,…

We are exploring low-dose proton radiography and computed tomography (pCT) as techniques to improve the accuracy of proton treatment planning and to provide artifact-free images for verification and adaptive therapy at the time of…

The highly energetic electrons in a transmission electron microscope (TEM) can alter or even completely destroy the structure of samples before sufficient information can be obtained. This is especially problematic in the case of zeolites,…

材料科学 · 物理学 2021-05-05 Abner Velazco , Daen Jannis , Armand Béché , Johan Verbeeck

Magnetic resonance fingerprinting (MRF) provides a unique concept for simultaneous and fast acquisition of multiple quantitative MR parameters. Despite acquisition efficiency, adoption of MRF into the clinics is hindered by its dictionary…

图像与视频处理 · 电气工程与系统科学 2020-08-11 Fabian Balsiger , Alain Jungo , Olivier Scheidegger , Pierre G. Carlier , Mauricio Reyes , Benjamin Marty

Data from a multi-parametric MRI study of patients with possible early-stage prostate cancer was assessed with a view to creating an efficient clinical protocol. Based on a correlation analysis suggesting that diffusion-weighted imaging…

医学物理 · 物理学 2017-11-28 Ioannis Papadopoulos , Jonathan Phillips , Rhodri Evans , Neil Fenn , Sophie Schermer

We aim to investigate the feasibility of online monitoring of irradiation time (IRT) and scan time for FLASH radiotherapy using a pixelated semiconductor detector. Measurements of the time structure of FLASH irradiations were performed…

Tracking the migration of superparamagnetic iron oxide (SPIO) labeled immune cells in vivo is valuable for understanding the immunogenic response to cancer and therapies. Quantitative cell tracking using compressed sensing TurboSPI-based…

医学物理 · 物理学 2019-03-05 Zoe O'Brien-Moran , Chris V. Bowen , James A. Rioux , Kimberly D. Brewer