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The integration of artificial intelligence (AI) into pathology is advancing precision medicine by improving diagnosis, treatment planning, and patient outcomes. Digitised whole-slide images (WSIs) capture rich spatial and morphological…

Objective: The exchange of health-related data is subject to regional laws and regulations, such as the General Data Protection Regulation (GDPR) in the EU or the Health Insurance Portability and Accountability Act (HIPAA) in the United…

计算机与社会 · 计算机科学 2024-01-24 Tom Bisson , Michael Franz , Isil Dogan O , Daniel Romberg , Christoph Jansen , Peter Hufnagl , Norman Zerbe

We present a fully automated, anatomically guided deep learning pipeline for prostate cancer (PCa) risk stratification using routine MRI. The pipeline integrates three key components: an nnU-Net module for segmenting the prostate gland and…

Prostate cancer is the most common cancer in men worldwide and the second leading cause of cancer death in the United States. One of the prognostic features in prostate cancer is the Gleason grading of histopathology images. The Gleason…

图像与视频处理 · 电气工程与系统科学 2022-12-27 Mohammad Mahdi Behzadi , Mohammad Madani , Hanzhang Wang , Jun Bai , Ankit Bhardwaj , Anna Tarakanova , Harold Yamase , Ga Hie Nam , Sheida Nabavi

Multiple Instance Learning (MIL) has been widely applied in histopathology to classify Whole Slide Images (WSIs) with slide-level diagnoses. While the ground truth is established by expert pathologists, the slides can be difficult to…

计算机视觉与模式识别 · 计算机科学 2026-03-11 Marie Arrivat , Rémy Peyret , Elsa Angelini , Pietro Gori

Pathologists diagnose and grade prostate cancer by examining tissue from needle biopsies on glass slides. The cancer's severity and risk of metastasis are determined by the Gleason grade, a score based on the organization and morphology of…

图像与视频处理 · 电气工程与系统科学 2022-09-28 Alessandro Ferrero , Beatrice Knudsen , Deepika Sirohi , Ross Whitaker

We study the attention of pathologists as they examine whole-slide images (WSIs) of prostate cancer tissue using a digital microscope. To the best of our knowledge, our study is the first to report in detail how pathologists navigate WSIs…

图像与视频处理 · 电气工程与系统科学 2022-05-04 Souradeep Chakraborty , Ke Ma , Rajarsi Gupta , Beatrice Knudsen , Gregory J. Zelinsky , Joel H. Saltz , Dimitris Samaras

Histology slide digitization is becoming essential for telepathology (remote consultation), knowledge sharing (education), and using the state-of-the-art artificial intelligence algorithms (augmented/automated end-to-end clinical…

图像与视频处理 · 电气工程与系统科学 2024-05-15 Talat Zehra , Joseph Marino , Wendy Wang , Grigoriy Frantsuzov , Saad Nadeem

Cervical Cancer continues to be the leading gynecological malignancy, posing a persistent threat to women's health on a global scale. Early screening via cytology Whole Slide Image (WSI) diagnosis is critical to prevent this Cancer…

计算机视觉与模式识别 · 计算机科学 2024-07-30 Honglin Li , Yusuan Sun , Chenglu Zhu , Yunlong Zhang , Shichuan Zhang , Zhongyi Shui , Pingyi Chen , Jingxiong Li , Sunyi Zheng , Can Cui , Lin Yang

Prostate cancer is one of the main diseases affecting men worldwide. The gold standard for diagnosis and prognosis is the Gleason grading system. In this process, pathologists manually analyze prostate histology slides under microscope, in…

图像与视频处理 · 电气工程与系统科学 2021-05-24 Julio Silva-Rodríguez , Adrián Colomer , Jose Dolz , Valery Naranjo

Prostate cancer pathology plays a crucial role in clinical management but is time-consuming. Artificial intelligence (AI) shows promise in detecting prostate cancer and grading patterns. We tested an AI-based digital twin of a pathologist,…

Reproducibility of AI models on biomedical data still stays as a major concern for their acceptance into the clinical practice. Initiatives for reproducibility in the development of predictive biomarkers as the MAQC Consortium already…

定量方法 · 定量生物学 2020-11-18 Nicole Bussola , Alessia Marcolini , Valerio Maggio , Giuseppe Jurman , Cesare Furlanello

Worldwide, prostate cancer is one of the main cancers affecting men. The final diagnosis of prostate cancer is based on the visual detection of Gleason patterns in prostate biopsy by pathologists. Computer-aided-diagnosis systems allow to…

计算机视觉与模式识别 · 计算机科学 2020-05-26 Amartya Kalapahar , Julio Silva-Rodríguez , Adrián Colomer , Fernando López-Mir , Valery Naranjo

Artificial intelligence may assist healthcare systems in meeting increasing demand for pathology services while maintaining diagnostic quality and reducing turnaround time and costs. We aimed to investigate the performance of an…

Artificial Intelligence (AI) has great potential to improve health outcomes by training systems on vast digitized clinical datasets. Computational Pathology, with its massive amounts of microscopy image data and impact on diagnostics and…

图像与视频处理 · 电气工程与系统科学 2024-05-24 Gabriele Campanella , Eugene Fluder , Jennifer Zeng , Chad Vanderbilt , Thomas J. Fuchs

The potential of artificial intelligence (AI) in digital pathology is limited by technical inconsistencies in the production of whole slide images (WSIs), leading to degraded AI performance and posing a challenge for widespread clinical…

Prostate cancer diagnosis through MR imaging have currently relied on radiologists' interpretation, whilst modern AI-based methods have been developed to detect clinically significant cancers independent of radiologists. In this study, we…

图像与视频处理 · 电气工程与系统科学 2026-01-09 Xiangcen Wu , Yipei Wang , Qianye Yang , Natasha Thorley , Shonit Punwani , Veeru Kasivisvanathan , Ester Bonmati , Yipeng Hu

We developed a software pipeline for quality control (QC) of histopathology whole slide images (WSIs) that segments various regions, such as blurs of different levels, tissue regions, tissue folds, and pen marks. Given the necessity and…

图像与视频处理 · 电气工程与系统科学 2025-06-17 Abhijeet Patil , Garima Jain , Harsh Diwakar , Jay Sawant , Tripti Bameta , Swapnil Rane , Amit Sethi

Pathological image analysis is a crucial field in computer-aided diagnosis, where deep learning is widely applied. Transfer learning using pre-trained models initialized on natural images has effectively improved the downstream pathological…

图像与视频处理 · 电气工程与系统科学 2023-10-30 Nan Ying , Yanli Lei , Tianyi Zhang , Shangqing Lyu , Chunhui Li , Sicheng Chen , Zeyu Liu , Yu Zhao , Guanglei Zhang

Standard of care diagnostic procedure for suspected skin cancer is microscopic examination of hematoxylin \& eosin stained tissue by a pathologist. Areas of high inter-pathologist discordance and rising biopsy rates necessitate higher…