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In studies of maternal exposure to air pollution a children's health outcome is regressed on exposures observed during pregnancy. The distributed lag nonlinear model (DLNM) is a statistical method commonly implemented to estimate an…

统计方法学 · 统计学 2021-06-16 Daniel Mork , Ander Wilson

This study quantifies the association between air pollution and mortality in Ontario, Canada. Exposure-response relationships in air pollution epidemiology are complex due to three features: time-lagged associations, non-linear…

统计方法学 · 统计学 2026-04-27 Tianyi Pan , Hwashin Hyun Shin , Alex Stringer , Glen McGee

Quantifying associations between short-term exposure to ambient air pollution and health outcomes is an important public health priority. Many studies have investigated the association considering delayed effects within the past few days.…

统计方法学 · 统计学 2025-05-22 Tianyi Pan , Hwashin Hyun Shin , Glen McGee , Alex Stringer

In environmental health research there is often interest in the effect of an exposure on a health outcome assessed on the same day and several subsequent days or lags. Distributed lag nonlinear models (DLNM) are a well-established…

统计方法学 · 统计学 2023-10-05 Daniel Mork , Ander Wilson

Maternal exposure to air pollution during pregnancy has a substantial public health impact. Epidemiological evidence supports an association between maternal exposure to air pollution and low birth weight. A popular method to estimate this…

Distributed lag models are useful in environmental epidemiology as they allow the user to investigate critical windows of exposure, defined as the time period during which exposure to a pollutant adversely affects health outcomes. Recent…

统计方法学 · 统计学 2021-08-02 Joseph Antonelli , Ander Wilson , Brent Coull

Distributed lag non-linear models (DLNM) have gained popularity for modeling nonlinear lagged relationships between exposures and outcomes. When applied to spatially referenced data, these models must account for spatial dependence, a…

统计方法学 · 统计学 2025-12-09 Sara Rutten , Bryan Sumalinab , Oswaldo Gressani , Thomas Neyens , Elisa Duarte , Niel Hens , Christel Faes

When examining the relationship between an exposure and an outcome, there is often a time lag between exposure and the observed effect on the outcome. A common statistical approach for estimating the relationship between the outcome and…

统计方法学 · 统计学 2025-04-28 Seongwon Im , Ander Wilson , Daniel Mork

Exposure to environmental pollutants during the gestational period can significantly impact infant health outcomes, such as birth weight and neurological development. Identifying critical windows of susceptibility, which are specific…

应用统计 · 统计学 2024-08-19 Yisen Jin , Aaron J. Molstad , Ander Wilson , Joseph Antonelli

Epidemiological research supports an association between maternal exposure to air pollution during pregnancy and adverse children's health outcomes. Advances in exposure assessment and statistics allow for estimation of both critical…

Distributed lag non-linear models (DLNMs) are a popular approach to flexibly model the effect of time-delayed exposures. Classical DLNMs specify a common exposure-lag-response relationship across geographical areas. However, this…

统计方法学 · 统计学 2026-03-20 Sara Rutten , Thomas Neyens , Elisa Duarte , Antonio Gasparrini , Christel Faes

Distributed Lag Models (DLMs) and similar regression approaches such as MIDAS have been used for many decades in econometrics and more recently to investigate how poor air quality adversely affects human health. In this paper we describe…

统计方法学 · 统计学 2025-01-30 Daniel Dempsey , Jason Wyse

An important goal of environmental health research is to assess the health risks posed by mixtures of multiple environmental exposures. In these mixtures analyses, flexible models like Bayesian kernel machine regression and multiple index…

统计方法学 · 统计学 2025-12-29 Glen McGee , Joseph Antonelli

Exposure to diverse non-genetic factors, known as the exposome, is a critical determinant of health outcomes. However, analyzing the exposome presents significant methodological challenges, including: high collinearity among exposures, the…

统计方法学 · 统计学 2025-10-10 Matteo Amestoy , Mark van de Wiel , Jeroen Lakerveld , Wessel van Wieringen

Spatio-temporal prediction of levels of an environmental exposure is an important problem in environmental epidemiology. Our work is motivated by multiple studies on the spatio-temporal distribution of mobile source, or traffic related,…

应用统计 · 统计学 2014-11-14 Nikolay Bliznyuk , Christopher J. Paciorek , Joel Schwartz , Brent Coull

Epidemiological evidence supports an association between exposure to air pollution during pregnancy and birth and child health outcomes. Typically, such associations are estimated by regressing an outcome on daily or weekly measures of…

Exposures to environmental chemicals during gestation can alter health status later in life. Most studies of maternal exposure to chemicals during pregnancy have focused on a single chemical exposure observed at high temporal resolution.…

Although distributed lag non-linear models (DLNMs) are commonly used to quantify delayed and non-linear exposure-response relationships, most existing applications assume that these relationships are constant across space. However, in many…

统计方法学 · 统计学 2026-04-13 Sara Rutten , Thomas Neyens , Elisa Duarte , Antonio Gasparrini , Christel Faes

We present a statistical modelling framework for implementing Distributed Lag Models (DLMs), encompassing several extensions of the approach to capture the temporally distributed effect from covariates via regression. We place DLMs in the…

Estimation of the long-term health effects of air pollution is a challenging task, especially when modelling small-area disease incidence data in an ecological study design. The challenge comes from the unobserved underlying spatial…

统计方法学 · 统计学 2013-05-24 Duncan Lee , Alastair Rushworth , Sujit K. Sahu
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