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Living systems implement and execute an extraordinary plethora of computational tasks. The inherent degree of large scale coordination emerges as a global property, from the intricate sea of microscopic interactions. The brain, with its…

无序系统与神经网络 · 物理学 2018-01-03 Duccio Fanelli , Francesco Ginelli , Roberto Livi , Niccolò Zagli , Clement Zankoc

Quantifying stochastic processes is essential to understand many natural phenomena, particularly in biology, including cell-fate decision in developmental processes as well as genesis and progression of cancers. While various attempts have…

统计力学 · 物理学 2017-06-28 Ying Tang , Ruoshi Yuan , Gaowei Wang , Xiaomei Zhu , Ping Ao

In recurrent neural networks (RNNs) used to model biological neural networks, noise is typically introduced during training to emulate biological variability and regularize learning. The expectation is that removing the noise at test time…

神经与进化计算 · 计算机科学 2026-01-09 Noah Eckstein , Manoj Srinivasan

We have analyzed the effects of the addition of external noise to non-dynamical systems displaying intrinsic noise, and established general conditions under which stochastic resonance appears. The criterion we have found may be applied to a…

凝聚态物理 · 物理学 2016-08-15 J. M. G. Vilar , G. Gomila , J. M. Rubí

Biological neural systems encode and transmit information as patterns of activity tracing complex trajectories in high-dimensional state-spaces, inspiring alternative paradigms of information processing. Heteroclinic networks, naturally…

神经元与认知 · 定量生物学 2021-10-26 Giovanni Sirio Carmantini , Fabio Schittler Neves , Marc Timme , Serafim Rodrigues

One central theme in machine learning is function estimation from sparse and noisy data. An example is supervised learning where the elements of the training set are couples, each containing an input location and an output response. In the…

机器学习 · 计算机科学 2023-10-05 Alberto Giaretta , Mauro Bisiacco , Gianluigi Pillonetto

The dynamics of tumor-immune interactions within a complex tumor microenvironment are typically modeled using a system of ordinary differential equations or partial differential equations. These models introduce some unknown parameters that…

定量方法 · 定量生物学 2025-10-22 Bishal Chhetri , B. V. Rathish Kumar

We present PINNACLE, an open-source computational framework for physics-informed neural networks (PINNs) that integrates modern training strategies, multi-GPU acceleration, and hybrid quantum-classical architectures within a unified modular…

In the study of complex dynamical systems, understanding and accurately modeling the underlying physical processes is crucial for predicting system behavior and designing effective interventions. Yet real-world systems exhibit pronounced…

机器学习 · 统计学 2025-07-15 Ridwan Olabiyi , Han Hu , Ashif Iquebal

Regulation of intrinsic noise in gene expression is essential for many cellular functions. Correspondingly, there is considerable interest in understanding how different molecular mechanisms of gene expression impact variations in protein…

分子网络 · 定量生物学 2011-03-02 Tao Jia , Rahul V. Kulkarni

Research in modern data-driven dynamical systems is typically focused on the three key challenges of high dimensionality, unknown dynamics, and nonlinearity. The dynamic mode decomposition (DMD) has emerged as a cornerstone for modeling…

流体动力学 · 物理学 2022-04-27 Peter J. Baddoo , Benjamin Herrmann , Beverley J. McKeon , Steven L. Brunton

The intrinsic stochasticity of gene expression can lead to large variability of protein levels across a population of cells. Variability (or noise) in protein distributions can be modulated by cellular mechanisms of gene regulation; in…

分子网络 · 定量生物学 2011-03-02 Tao Jia , Rahul V. Kulkarni

Physics-informed neural networks (PINNs) constitute a flexible approach to both finding solutions and identifying parameters of partial differential equations. Most works on the topic assume noiseless data, or data contaminated with weak…

机器学习 · 统计学 2024-06-21 Philipp Pilar , Niklas Wahlström

We propose a novel deep neural network architecture for speech recognition that explicitly employs knowledge of the background environmental noise within a deep neural network acoustic model. A deep neural network is used to predict the…

计算与语言 · 计算机科学 2016-10-03 Suyoun Kim , Bhiksha Raj , Ian Lane

Noise is usually regarded as adversarial to extract the effective dynamics from time series, such that the conventional data-driven approaches usually aim at learning the dynamics by mitigating the noisy effect. However, noise can have a…

适应与自组织系统 · 物理学 2023-09-12 Zequn Lin , Zhaofan Lu , Zengru Di , Ying Tang

This paper proposes a sparse identification of nonlinear dynamics (SINDy) with control and exogenous inputs for highly accurate and reliable prediction. Although SINDy is recognized as a remarkable approach for identifying nonlinear…

系统与控制 · 电气工程与系统科学 2025-10-21 Shuichi Yahagi , Ansei Yonezawa , Hiroki Seto , Heisei Yonezawa , Itsuro Kajiwara

End-to-end learning of dynamical systems with black-box models, such as neural ordinary differential equations (ODEs), provides a flexible framework for learning dynamics from data without prescribing a mathematical model for the dynamics.…

机器学习 · 统计学 2022-06-20 Paidamoyo Chapfuwa , Sherri Rose , Lawrence Carin , Edward Meeds , Ricardo Henao

Learning models of dynamical systems with external inputs, which may be, for example, nonsmooth or piecewise, is crucial for studying complex phenomena and predicting future state evolution, which is essential for applications such as…

机器学习 · 计算机科学 2025-04-16 Zhaoyi Li , Wenjie Mei , Ke Yu , Yang Bai , Shihua Li

A new framework for nonlinear system identification is presented in terms of optimal fitting of stable nonlinear state space equations to input/output/state data, with a performance objective defined as a measure of robustness of the…

最优化与控制 · 数学 2016-11-17 Mark M. Tobenkin , Ian R. Manchester , Jennifer Wang , Alexandre Megretski , Russ Tedrake

The discovery of governing differential equations from data is an open frontier in machine learning. The sparse identification of nonlinear dynamics (SINDy) \citep{brunton_discovering_2016} framework enables data-driven discovery of…

机器学习 · 计算机科学 2023-10-10 Mozes Jacobs , Bingni W. Brunton , Steven L. Brunton , J. Nathan Kutz , Ryan V. Raut