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The integration of heterogeneous multi-omics datasets at a systems level remains a central challenge for developing analytical and computational models in precision cancer diagnostics. This paper introduces Multi-Omics Graph…

Energy-Based Models (EBMs) assign unnormalized log-probability to data samples. This functionality has a variety of applications, such as sample synthesis, data denoising, sample restoration, outlier detection, Bayesian reasoning, and many…

机器学习 · 统计学 2019-12-23 Zengyi Li , Yubei Chen , Friedrich T. Sommer

Network estimation and variable selection have been extensively studied in the statistical literature, but only recently have those two challenges been addressed simultaneously. In this paper, we seek to develop a novel method to…

统计方法学 · 统计学 2024-06-11 Nathan Osborne , Christine B. Peterson , Marina Vannucci

The interpretability of neural networks has recently received extensive attention. Previous prototype-based explainable networks involved prototype activation in both reasoning and interpretation processes, requiring specific explainable…

计算机视觉与模式识别 · 计算机科学 2022-11-22 Yitao Peng , Yihang Liu , Longzhen Yang , Lianghua He

Recent advances in image generation have made diffusion models powerful tools for creating high-quality images. However, their iterative denoising process makes understanding and interpreting their semantic latent spaces more challenging…

计算与语言 · 计算机科学 2024-11-06 E. Zhixuan Zeng , Yuhao Chen , Alexander Wong

Deep generative models, while revolutionizing fields like image and text generation, largely operate as opaque ``black boxes'', hindering human understanding, control, and alignment. While methods like sparse autoencoders (SAEs) show…

机器学习 · 计算机科学 2026-04-03 Lingjing Kong , Shaoan Xie , Guangyi Chen , Yuewen Sun , Xiangchen Song , Eric P. Xing , Kun Zhang

Deep learning models have achieved remarkable success in different areas of machine learning over the past decade; however, the size and complexity of these models make them difficult to understand. In an effort to make them more…

计算机视觉与模式识别 · 计算机科学 2022-06-20 Vikram V. Ramaswamy , Sunnie S. Y. Kim , Nicole Meister , Ruth Fong , Olga Russakovsky

The use of sophisticated machine learning models for critical decision making is faced with a challenge that these models are often applied as a "black-box". This has led to an increased interest in interpretable machine learning, where…

人工智能 · 计算机科学 2020-07-22 Catarina Moreira , Yu-Liang Chou , Mythreyi Velmurugan , Chun Ouyang , Renuka Sindhgatta , Peter Bruza

With the advent of highly predictive but opaque deep learning models, it has become more important than ever to understand and explain the predictions of such models. Existing approaches define interpretability as the inverse of complexity…

The problem of signal detection using a flexible and general model is considered. Due to applicability and flexibility of sparse signal representation and approximation, it has attracted a lot of attention in many signal processing areas.…

信息论 · 计算机科学 2016-02-17 Mohsen Joneidi , Parvin Ahmadi , Mostafa Sadeghi , Nazanin Rahnavard

We present a framework that leverages the Discrete Empirical Interpolation Method (DEIM) for interpretable deep learning and dynamical system analysis. Although DEIM efficiently approximates nonlinear terms in projection-based reduced-order…

机器学习 · 计算机科学 2026-04-03 Hojin Kim , Romit Maulik

Sparse Autoencoders (SAEs) have emerged as a popular tool for interpreting the hidden states of large language models (LLMs). By learning to reconstruct activations from a sparse bottleneck layer, SAEs discover interpretable features from…

计算机视觉与模式识别 · 计算机科学 2025-09-19 Matthew Lyle Olson , Musashi Hinck , Neale Ratzlaff , Changbai Li , Phillip Howard , Vasudev Lal , Shao-Yen Tseng

Time-varying linear state-space models are powerful tools for obtaining mathematically interpretable representations of neural signals. For example, switching and decomposed models describe complex systems using latent variables that evolve…

It has been observed that deep neural networks (DNNs) often use both genuine as well as spurious features. In this work, we propose "Amending Inherent Interpretability via Self-Supervised Masking" (AIM), a simple yet interestingly effective…

计算机视觉与模式识别 · 计算机科学 2025-08-18 Eyad Alshami , Shashank Agnihotri , Bernt Schiele , Margret Keuper

The discovery of disease subtypes is an essential step for developing precision medicine, and disease subtyping via omics data has become a popular approach. While promising, subtypes obtained from existing approaches are not necessarily…

定量方法 · 定量生物学 2022-03-01 Lingsong Meng , Dorina Avram , George Tseng , Zhiguang Huo

Ensembles improve prediction performance and allow uncertainty quantification by aggregating predictions from multiple models. In deep ensembling, the individual models are usually black box neural networks, or recently, partially…

机器学习 · 统计学 2022-05-26 Lucas Kook , Andrea Götschi , Philipp FM Baumann , Torsten Hothorn , Beate Sick

Word embeddings are a powerful natural language processing technique, but they are extremely difficult to interpret. To enable interpretable NLP models, we create vectors where each dimension is inherently interpretable. By inherently…

计算与语言 · 计算机科学 2021-09-29 Adly Templeton

How to aggregate information from multiple instances is a key question multiple instance learning. Prior neural models implement different variants of the well-known encoder-decoder strategy according to which all input features are encoded…

机器学习 · 计算机科学 2022-07-26 Markus Zopf

While the activations of neurons in deep neural networks usually do not have a simple human-understandable interpretation, sparse autoencoders (SAEs) can be used to transform these activations into a higher-dimensional latent space which…

机器学习 · 计算机科学 2025-08-07 Gonçalo Paulo , Alex Mallen , Caden Juang , Nora Belrose

Unsupervised approaches to large language model (LLM) interpretability, such as sparse autoencoders (SAEs), offer a way to decode LLM activations into interpretable and, ideally, controllable concepts. On the one hand, these approaches…

机器学习 · 计算机科学 2026-03-03 Shruti Joshi , Andrea Dittadi , Sébastien Lachapelle , Dhanya Sridhar