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Inference of the marginal likelihood of sample allele configurations using backward algorithms yields identical results with the Kingman coalescent, the Moran model, and the diffusion model (up to a scaling of time). For inference of…

种群与进化 · 定量生物学 2021-12-20 Claus Vogl , Sandra Peer , Lynette Caitlin Mikula

Phylogenetic analyses which include fossils or molecular sequences that are sampled through time require models that allow one sample to be a direct ancestor of another sample. As previously available phylogenetic inference tools assume…

种群与进化 · 定量生物学 2014-12-08 Alexandra Gavryushkina , David Welch , Tanja Stadler , Alexei Drummond

Gradients of probabilistic model likelihoods with respect to their parameters are essential for modern computational statistics and machine learning. These calculations are readily available for arbitrary models via automatic…

The search for similarity and dissimilarity measures on phylogenetic trees has been motivated by the computation of consensus trees, the search by similarity in phylogenetic databases, and the assessment of clustering results in…

种群与进化 · 定量生物学 2011-11-09 Francesc Rossello , Gabriel Valiente

One approach to estimating a species tree from a collection of gene trees is to first estimate probabilities of clades from the gene trees, and then to construct the species tree from the estimated clade probabilities. While a greedy…

种群与进化 · 定量生物学 2012-11-14 Elizabeth S. Allman , James H. Degnan , John A. Rhodes

Comparative and evolutive ecologists are interested in the distribution of quantitative traits among related species. The classical framework for these distributions consists of a random process running along the branches of a phylogenetic…

应用统计 · 统计学 2017-08-24 Paul Bastide , Mahendra Mariadassou , Stéphane Robin

We consider the phylogenetic tree reconstruction problem with insertions and deletions (indels). Phylogenetic algorithms proceed under a model where sequences evolve down the model tree, and given sequences at the leaves, the problem is to…

数据结构与算法 · 计算机科学 2019-02-22 Arun Ganesh , Qiuyi Zhang

The clique tree algorithm is the standard method for doing inference in Bayesian networks. It works by manipulating clique potentials - distributions over the variables in a clique. While this approach works well for many networks, it is…

人工智能 · 计算机科学 2013-01-30 Daphne Koller , Uri Lerner , Dragomir Anguelov

Like mean, quantile and variance, mode is also an important measure of central tendency and data summary. Many practical questions often focus on "Which element (gene or file or signal) occurs most often or is the most typical among all…

统计方法学 · 统计学 2012-08-03 Keming Yu , Katerina Aristodemou

This work presents a novel posterior inference method for models with intractable evidence and likelihood functions. Error-guided likelihood-free MCMC, or EG-LF-MCMC in short, has been developed for scientific applications, where a…

机器学习 · 统计学 2021-04-27 Volodimir Begy , Erich Schikuta

Attempting to recognize a tree inside a phylogenetic network is a fundamental undertaking in evolutionary analysis. In the last few years, therefore, tree-based phylogenetic networks, which are defined by a spanning tree called a…

组合数学 · 数学 2020-09-29 Momoko Hayamizu

In this paper, we present a novel approach to accelerate the Bayesian inference process, focusing specifically on the nested sampling algorithms. Bayesian inference plays a crucial role in cosmological parameter estimation, providing a…

天体物理仪器与方法 · 物理学 2024-10-17 Isidro Gómez-Vargas , J. Alberto Vázquez

The displayed tree phylogenetic network model is shown to sit as a natural submodel of the graphical model associated to a directed acyclic graph (DAG). This representation allows to derive a number of results about the displayed tree…

种群与进化 · 定量生物学 2025-08-01 Seth Sullivant

Phylogenetics is a classical methodology in computational biology that today has become highly relevant for medical investigation of single-cell data, e.g., in the context of cancer development. The exponential size of the tree space is,…

种群与进化 · 定量生物学 2023-01-25 Hazal Koptagel , Oskar Kviman , Harald Melin , Negar Safinianaini , Jens Lagergren

Distance-based approaches in phylogenetics such as Neighbor-Joining are a fast and popular approach for building trees. These methods take pairs of sequences from them construct a value that, in expectation, is additive under a stochastic…

种群与进化 · 定量生物学 2008-08-21 Mike Steel

Modern high-stakes systems, such as healthcare or robotics, often generate vast streaming event sequences. Our goal is to design an efficient, plug-and-play tool to elicit logic tree-based explanations from Large Language Models (LLMs) to…

机器学习 · 计算机科学 2024-07-01 Zitao Song , Chao Yang , Chaojie Wang , Bo An , Shuang Li

Variable selection and classification are common objectives in the analysis of high-dimensional data. Most such methods make distributional assumptions that may not be compatible with the diverse families of distributions data can take. A…

统计方法学 · 统计学 2019-08-28 Weichang Yu , Lamiae Azizi , John T. Ormerod

Since the advent of modern bioinformatics, the challenging, multifaceted problem of reconstructing phylogenetic history from biological sequences has hatched perennial statistical and algorithmic innovation. Studies of the phylogenetic…

数据结构与算法 · 计算机科学 2024-03-05 Matthew Andres Moreno , Santiago Rodriguez Papa , Emily Dolson

Phylogenetic inference is an intractable statistical problem on a complex space. Markov chain Monte Carlo methods are the primary tool for Bayesian phylogenetic inference but it is challenging to construct efficient schemes to explore the…

统计方法学 · 统计学 2022-10-11 Luke J. Kelly , Robin J. Ryder , Grégoire Clarté

Probabilistic models over strings have played a key role in developing methods allowing indels to be treated as phylogenetically informative events. There is an extensive literature on using automata and transducers on phylogenies to do…

种群与进化 · 定量生物学 2013-07-15 Alexandre Bouchard-Côté
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