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Integrating heterogeneous biomedical data including imaging, omics, and clinical records supports accurate diagnosis and personalised care. Graph-based models fuse such non-Euclidean data by capturing spatial and relational structure, yet…

基因组学 · 定量生物学 2025-05-06 Alireza Sadeghi , Farshid Hajati , Ahmadreza Argha , Nigel H Lovell , Min Yang , Hamid Alinejad-Rokny

Clinical decision-making requires reasoning over incomplete, imprecise, and linguistically expressed patient narratives. While large language models (LLMs) excel at extracting latent information from natural language, they lack the…

人工智能 · 计算机科学 2026-05-26 Xiaoyang Fan , Yufan Cai , Zhe Hou , Jin Song Dong

Large language models (LLMs) are often portrayed as merely imitating linguistic patterns without genuine understanding. We argue that recent findings in mechanistic interpretability (MI), the emerging field probing the inner workings of…

计算与语言 · 计算机科学 2026-02-26 Pierre Beckmann , Matthieu Queloz

Although large language models (LLMs) store vast amount of knowledge in their parameters, they still have limitations in the memorization and utilization of certain knowledge, leading to undesired behaviors such as generating untruthful and…

计算与语言 · 计算机科学 2025-05-28 Moxin Li , Yong Zhao , Wenxuan Zhang , Shuaiyi Li , Wenya Xie , See-Kiong Ng , Tat-Seng Chua , Yang Deng

Background: Identification of the interactions and regulatory relations between biomolecules play pivotal roles in understanding complex biological systems and the mechanisms underlying diverse biological functions. However, the collection…

计算与语言 · 计算机科学 2025-04-24 Gilchan Park , Byung-Jun Yoon , Xihaier Luo , Vanessa López-Marrero , Shinjae Yoo , Shantenu Jha

Clinical Decision Support Systems (CDSS) utilize evidence-based knowledge and patient data to offer real-time recommendations, with Large Language Models (LLMs) emerging as a promising tool to generate plain-text explanations for medical…

计算与语言 · 计算机科学 2023-10-04 D. Umerenkov , G. Zubkova , A. Nesterov

While pioneering deep learning methods have made great strides in analyzing electronic health record (EHR) data, they often struggle to fully capture the semantics of diverse medical codes from limited data. The integration of external…

机器学习 · 计算机科学 2024-08-26 Zhihao Yu , Yujie Jin , Yongxin Xu , Xu Chu , Yasha Wang , Junfeng Zhao

Large Language Models (LLMs) have demonstrated impressive capabilities in role-playing scenarios, particularly in simulating domain-specific experts using tailored prompts. This ability enables LLMs to adopt the persona of individuals with…

人工智能 · 计算机科学 2025-01-14 Xinyao Ma , Rui Zhu , Zihao Wang , Jingwei Xiong , Qingyu Chen , Haixu Tang , L. Jean Camp , Lucila Ohno-Machado

Large language models that require multiple GPU cards to host are usually the most capable models. It is necessary to understand and steer these models, but the current technologies do not support the interpretability and steering of these…

机器学习 · 计算机科学 2026-04-09 Dev Arpan Desai , Shaoyi Huang , Zining Zhu

Interpretability for machine learning models in medical imaging (MLMI) is an important direction of research. However, there is a general sense of murkiness in what interpretability means. Why does the need for interpretability in MLMI…

Large Language Models have been tested on medical student-level questions, but their performance in specialized fields like Critical Care Medicine (CCM) is less explored. This study evaluated Meta-Llama 3.1 models (8B and 70B parameters) on…

This paper presents an in-depth analysis of Large Language Models (LLMs), focusing on LLaMA, a prominent open-source foundational model in natural language processing. Instead of assessing LLaMA through its generative output, we design…

计算与语言 · 计算机科学 2024-01-10 Nuo Chen , Ning Wu , Shining Liang , Ming Gong , Linjun Shou , Dongmei Zhang , Jia Li

Large language model (LLM) architectures are often described as functionally hierarchical: Early layers process syntax, middle layers begin to parse semantics, and late layers integrate information. The present work revisits these ideas.…

计算与语言 · 计算机科学 2025-01-14 Paul C. Bogdan

Intermediate Representations (IRs) play a critical role in compiler design and program analysis, yet their comprehension by Large Language Models (LLMs) remains underexplored. In this paper, we present an explorative empirical study…

机器学习 · 计算机科学 2025-06-06 Hailong Jiang , Jianfeng Zhu , Yao Wan , Bo Fang , Hongyu Zhang , Ruoming Jin , Qiang Guan

Large language models (LLMs) have demonstrated impressive capabilities across diverse languages. This study explores how LLMs handle multilingualism. Based on observed language ratio shifts among layers and the relationships between network…

计算与语言 · 计算机科学 2024-11-12 Yiran Zhao , Wenxuan Zhang , Guizhen Chen , Kenji Kawaguchi , Lidong Bing

Purpose: Large Language Models (LLMs) like GPT (Generative Pre-trained Transformer) from OpenAI and LLaMA (Large Language Model Meta AI) from Meta AI are increasingly recognized for their potential in the field of cheminformatics,…

生物大分子 · 定量生物学 2024-05-22 Shaghayegh Sadeghi , Alan Bui , Ali Forooghi , Jianguo Lu , Alioune Ngom

The interpretability of deep neural networks has become a subject of great interest within the medical and healthcare domain. This attention stems from concerns regarding transparency, legal and ethical considerations, and the medical…

图像与视频处理 · 电气工程与系统科学 2023-11-20 Mahbub Ul Alam , Jaakko Hollmén , Jón Rúnar Baldvinsson , Rahim Rahmani

Large language models (LLMs) are being explored for diagnostic decision support, yet their ability to estimate pre-test probabilities, vital for clinical decision-making, remains limited. This study evaluates two LLMs, Mistral-7B and…

Since the release of ChatGPT and GPT-4, large language models (LLMs) and multimodal large language models (MLLMs) have attracted widespread attention for their exceptional capabilities in understanding, reasoning, and generation,…

计算与语言 · 计算机科学 2024-12-31 Hanguang Xiao , Feizhong Zhou , Xingyue Liu , Tianqi Liu , Zhipeng Li , Xin Liu , Xiaoxuan Huang

Cognitive decline often surfaces in language years before diagnosis. It is frequently non-experts, such as those closest to the patient, who first sense a change and raise concern. As LLMs become integrated into daily communication and used…

计算与语言 · 计算机科学 2025-05-20 Lotem Peled-Cohen , Maya Zadok , Nitay Calderon , Hila Gonen , Roi Reichart