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Major depressive disorder (MDD) impacts more than 300 million people worldwide, highlighting a significant public health issue. However, the uneven distribution of medical resources and the complexity of diagnostic methods have resulted in…

计算与语言 · 计算机科学 2025-05-02 Yuyang Sha , Hongxin Pan , Wei Xu , Weiyu Meng , Gang Luo , Xinyu Du , Xiaobing Zhai , Henry H. Y. Tong , Caijuan Shi , Kefeng Li

Early detection of depression from social media data offers a valuable opportunity for timely intervention. However, this task poses significant challenges, requiring both professional medical knowledge and the development of accurate and…

计算与语言 · 计算机科学 2025-03-20 Xiangyong Chen , Xiaochuan Lin

Depression is one of the leading causes of disability worldwide, posing a severe burden on individuals, healthcare systems, and society at large. Recent advancements in Large Language Models (LLMs) have shown promise in addressing mental…

计算与语言 · 计算机科学 2025-02-11 Shiyu Teng , Jiaqing Liu , Rahul Kumar Jain , Shurong Chai , Ruibo Hou , Tomoko Tateyama , Lanfen Lin , Yen-wei Chen

Automated depression diagnosis aims to analyze multimodal information from interview videos to predict participants' depression scores. Previous studies often lack clear explanations of how these scores were determined, limiting their…

人工智能 · 计算机科学 2026-03-19 Wei Zhang , Juan Chen , En Zhu , Wenhong Cheng , YunPeng Li , Yanbo J. Wang

Large Language Models (LLMs) have demonstrated strong reasoning capabilities in solving complex problems. However, current approaches primarily enhance reasoning through the elaboration of thoughts while neglecting the diversity of…

计算与语言 · 计算机科学 2025-04-25 Danqing Wang , Jianxin Ma , Fei Fang , Lei Li

An accurate differential diagnosis (DDx) is a cornerstone of medical care, often reached through an iterative process of interpretation that combines clinical history, physical examination, investigations and procedures. Interactive…

We propose a clinical decision support system (CDSS) for mental health diagnosis that combines the strengths of large language models (LLMs) and constraint logic programming (CLP). Having a CDSS is important because of the high complexity…

人工智能 · 计算机科学 2025-02-24 Brian Hyeongseok Kim , Chao Wang

Mental health disorders represent a burgeoning global public health challenge. While Large Language Models (LLMs) have demonstrated potential in psychiatric assessment, their clinical utility is severely constrained by benchmarks that lack…

人工智能 · 计算机科学 2026-02-04 Xiao Sun , Yuming Yang , Junnan Zhu , Jiang Zhong , Xinyu Zhou , Kaiwen Wei

Multimodal misinformation floods on various social media, and continues to evolve in the era of AI-generated content (AIGC). The emerged misinformation with low creation cost and high deception poses significant threats to society. While…

计算机视觉与模式识别 · 计算机科学 2025-11-18 Junjie Wu , Guohong Fu

Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if morphological alterations in the brain are linked to MDD,…

定量方法 · 定量生物学 2025-01-27 Roberto Goya-Maldonado , Tracy Erwin-Grabner , Ling-Li Zeng , Christopher R. K. Ching , Andre Aleman , Alyssa R. Amod , Zeynep Basgoze , Francesco Benedetti , Bianca Besteher , Katharina Brosch , Robin Bülow , Romain Colle , Colm G. Connolly , Emmanuelle Corruble , Baptiste Couvy-Duchesne , Kathryn Cullen , Udo Dannlowski , Christopher G. Davey , Annemiek Dols , Jan Ernsting , Jennifer W. Evans , Lukas Fisch , Paola Fuentes-Claramonte , Ali Saffet Gonul , Ian H. Gotlib , Hans J. Grabe , Nynke A. Groenewold , Dominik Grotegerd , Tim Hahn , J. Paul Hamilton , Laura K. M. Han , Ben J. Harrison , Tiffany C. Ho , Neda Jahanshad , Alec J. Jamieson , Andriana Karuk , Tilo Kircher , Bonnie Klimes-Dougan , Sheri-Michelle Koopowitz , Thomas Lancaster , Ramona Leenings , Meng Li , David E. J. Linden , Frank P. MacMaster , David M. A. Mehler , Susanne Meinert , Elisa Melloni , Bryon A. Mueller , Benson Mwangi , Igor Nenadić , Amar Ojha , Yasumasa Okamoto , Mardien L. Oudega , Brenda W. J. H. Penninx , Sara Poletti , Edith Pomarol-Clotet , Maria J. Portella , Elena Pozzi , Joaquim Radua , Elena Rodríguez-Cano , Matthew D. Sacchet , Raymond Salvador , Anouk Schrantee , Kang Sim , Jair C. Soares , Aleix Solanes , Dan J. Stein , Frederike Stein , Aleks Stolicyn , Sophia I. Thomopoulos , Yara J. Toenders , Aslihan Uyar-Demir , Eduard Vieta , Yolanda Vives-Gilabert , Henry Völzke , Martin Walter , Heather C. Whalley , Sarah Whittle , Nils Winter , Katharina Wittfeld , Margaret J. Wright , Mon-Ju Wu , Tony T. Yang , Carlos Zarate , Dick J. Veltman , Lianne Schmaal , Paul M. Thompson

Mental health forums offer valuable insights into psychological issues, stressors, and potential solutions. We propose MHINDR, a large language model (LLM) based framework integrated with DSM-5 criteria to analyze user-generated text,…

社会与信息网络 · 计算机科学 2025-10-01 Vaishali Agarwal , Sachin Thukral , Arnab Chatterjee

Depression poses significant challenges to patients and healthcare organizations, necessitating efficient assessment methods. Existing paradigms typically focus on a patient-doctor way that overlooks multi-role interactions, such as family…

人机交互 · 计算机科学 2026-03-10 Zhiyuan Zhou , Jilong Liu , Sanwang Wang , Shijie Hao , Yanrong Guo , Richang Hong

Depression is a growing concern gaining attention in both public discourse and AI research. While deep neural networks (DNNs) have been used for recognition, they still lack real-world effectiveness. Large language models (LLMs) show strong…

人机交互 · 计算机科学 2025-08-27 Yupei Li , Shuaijie Shao , Manuel Milling , Björn W. Schuller

Difficult-to-treat depression (DTD) has been proposed as a broader and more clinically comprehensive perspective on a person's depressive disorder where despite treatment, they continue to experience significant burden. We sought to develop…

计算与语言 · 计算机科学 2024-02-13 Isabelle Lorge , Dan W. Joyce , Niall Taylor , Alejo Nevado-Holgado , Andrea Cipriani , Andrey Kormilitzin

Multimodal Large Language Models (MLLMs) have demonstrated remarkable capabilities in document understanding. However, their reasoning processes remain largely black-box, making it difficult to ensure reliability and trustworthiness,…

计算机视觉与模式识别 · 计算机科学 2025-08-13 Wenwen Yu , Zhibo Yang , Yuliang Liu , Xiang Bai

Accurate clinical diagnosis requires extensive domain knowledge and complex clinical reasoning capabilities. Although large language models (LLMs) hold great potential for clinical reasoning, their high computational and memory requirements…

计算机与社会 · 计算机科学 2026-05-12 Xinchun Su , Chunxu Luo , Lipeng Ma , Yixuan Li , Weidong Yang

The differential diagnosis of neurodegenerative dementias is a challenging clinical task, mainly because of the overlap in symptom presentation and the similarity of patterns observed in structural neuroimaging. To improve diagnostic…

机器学习 · 计算机科学 2025-05-27 Andrew Zamai , Nathanael Fijalkow , Boris Mansencal , Laurent Simon , Eloi Navet , Pierrick Coupe

As demand for mental health care outpaces clinician-delivered assessment, scalable screening tools are increasingly needed. Large language models (LLMs) may identify psychiatric risk from patient narratives, but their reliability across…

计算与语言 · 计算机科学 2026-05-26 Jianfeng Zhu , Megan Korhummel , Ruoming Jin , Karin G. Coifman

Major depressive disorder is a serious and heterogeneous psychiatric disorder that needs accurate diagnosis. Resting-state functional MRI (rsfMRI), which captures multiple perspectives on brain structure, function, and connectivity, is…

机器学习 · 计算机科学 2023-08-21 Yunsong Luo , Wenyu Chen , Ling Zhan , Jiang Qiu , Tao Jia

Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by…

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