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Genome-Wide Association Studies are typically conducted using linear models to find genetic variants associated with common diseases. In these studies, association testing is done on a variant-by-variant basis, possibly missing out on…

In artificial neural networks trained with gradient descent, the weights used for processing stimuli are also used during backward passes to calculate gradients. For the real brain to approximate gradients, gradient information would have…

神经元与认知 · 定量生物学 2020-02-04 Jordan Guerguiev , Konrad P. Kording , Blake A. Richards

We present a new approach to automatic amortized inference in universal probabilistic programs which improves performance compared to current methods. Our approach is a variation of inference compilation (IC) which leverages deep neural…

机器学习 · 计算机科学 2019-10-29 William Harvey , Andreas Munk , Atılım Güneş Baydin , Alexander Bergholm , Frank Wood

Alzheimer's disease and Frontotemporal dementia are two major types of dementia. Their accurate diagnosis and differentiation is crucial for determining specific intervention and treatment. However, differential diagnosis of these two types…

图像与视频处理 · 电气工程与系统科学 2022-06-16 Huy-Dung Nguyen , Michaël Clément , Boris Mansencal , Pierrick Coupé

Physics-informed deep learning has emerged as a promising alternative for solving partial differential equations. However, for complex problems, training these networks can still be challenging, often resulting in unsatisfactory accuracy…

机器学习 · 计算机科学 2025-09-18 Wenqian Chen , Amanda A. Howard , Panos Stinis

One of the hallmark symptoms of Parkinson's Disease (PD) is the progressive loss of postural reflexes, which eventually leads to gait difficulties and balance problems. Identifying disruptions in brain function associated with gait…

机器学习 · 计算机科学 2023-07-26 Favour Nerrise , Qingyu Zhao , Kathleen L. Poston , Kilian M. Pohl , Ehsan Adeli

Physics-informed neural networks (PINNs) offer a powerful approach to solving partial differential equations (PDEs), which are ubiquitous in the quantitative sciences. Applied to both forward and inverse problems across various scientific…

The identification of Alzheimer's disease (AD) and its early stages using structural magnetic resonance imaging (MRI) has been attracting the attention of researchers. Various data-driven approaches have been introduced to capture subtle…

人工智能 · 计算机科学 2021-08-11 Changhyun Park , Heung-Il Suk

Retrieval-Augmented Generation (RAG), by incorporating external knowledge with parametric memory of language models, has become the state-of-the-art architecture for open-domain QA tasks. However, common knowledge bases are inherently…

计算与语言 · 计算机科学 2023-12-01 Zhebin Zhang , Xinyu Zhang , Yuanhang Ren , Saijiang Shi , Meng Han , Yongkang Wu , Ruofei Lai , Zhao Cao

Physics-informed neural network (PINN) is a powerful emerging method for studying forward-inverse problems of partial differential equations (PDEs), even from limited sample data. Variable coefficient PDEs, which model real-world phenomena,…

计算物理 · 物理学 2025-03-07 Hui-Juan Zhou , Yong Chen

Advancements in deep learning have enabled highly accurate arrhythmia detection from electrocardiogram (ECG) signals, but limited interpretability remains a barrier to clinical adoption. This study investigates the application of…

机器学习 · 计算机科学 2025-08-26 Joschka Beck , Arlene John

The paper presents a deep learning-aided iterative detection algorithm for massive overloaded MIMO systems. Since the proposed algorithm is based on the projected gradient descent method with trainable parameters, it is named as trainable…

信息论 · 计算机科学 2018-12-27 Satoshi Takabe , Masayuki Imanishi , Tadashi Wadayama , Kazunori Hayashi

Local explanation methods, also known as attribution methods, attribute a deep network's prediction to its input (cf. Baehrens et al. (2010)). We respond to the claim from Adebayo et al. (2018) that local explanation methods lack…

机器学习 · 计算机科学 2018-06-13 Mukund Sundararajan , Ankur Taly

Generalized additive models (GAMs) are favored in many regression and binary classification problems because they are able to fit complex, nonlinear functions while still remaining interpretable. In the first part of this paper, we…

机器学习 · 计算机科学 2019-06-03 Xuezhou Zhang , Sarah Tan , Paul Koch , Yin Lou , Urszula Chajewska , Rich Caruana

Research in Explainable Artificial Intelligence (XAI) is increasing, aiming to make deep learning models more transparent. Most XAI methods focus on justifying the decisions made by Artificial Intelligence (AI) systems in security-relevant…

Deep learning-based medical image analysis faces a significant barrier due to the lack of interpretability. Conventional explainable AI (XAI) techniques, such as Grad-CAM and SHAP, often highlight regions outside clinical interests. To…

图像与视频处理 · 电气工程与系统科学 2025-02-17 Yuhao Zhang , Mingcheng Zhu , Zhiyao Luo

A conventional Bayesian approach to prediction uses the posterior distribution to integrate out parameters in a density for unobserved data conditional on the observed data and parameters. When the true posterior is intractable, it is…

统计方法学 · 统计学 2026-02-27 Lucas Kock , Scott A. Sisson , G. S. Rodrigues , David J. Nott

Interpretation and improvement of deep neural networks relies on better understanding of their underlying mechanisms. In particular, gradients of classes or concepts with respect to the input features (e.g., pixels in images) are often used…

计算机视觉与模式识别 · 计算机科学 2020-12-02 Lennart Brocki , Neo Christopher Chung

Deep learning based automated pathological diagnosis has markedly improved diagnostic efficiency and reduced variability between observers, yet its clinical adoption remains limited by opaque model decisions and a lack of traceable…

Alzheimer's Disease is the most common cause of dementia. Accurate diagnosis and prognosis of this disease are essential to design an appropriate treatment plan, increasing the life expectancy of the patient. Intense research has been…

图像与视频处理 · 电气工程与系统科学 2023-01-05 Huy-Dung Nguyen , Michaël Clément , Boris Mansencal , Pierrick Coupé