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Cerebral autoregulation plays a key physiological role by limiting blood flow changes in the face of pressure fluctuations. Although the involved cellular processes are mechanically driven, the quantification of haemodynamic forces in…
Baroreflex (BR) and cerebral autoregulation (CA) are two important mechanisms regulating blood pressure and flow. However, the functional relationship between BR and CA in humans is unknown. Since BR impairment is an adverse prognostic…
Adequate brain perfusion is required for proper brain function and life. Maintaining optimal brain perfusion to avoid secondary brain injury is one of the main concerns of neurocritical care. Cerebral autoregulation is responsible for…
The cerebral autoregulation system (CAS), is a mechanism which aims to regulate pressure variations occurring in the cerebral circulatory system. At present, there only exist invasive methods and, in turn, they are not used to prevent…
Cerebral autoregulation refers to the brain's ability to maintain cerebral blood flow at an approximately constant level, despite changes in arterial blood pressure. The performance of this mechanism is often assessed using a ten-scale…
Intracardiac flow patterns are shaped by the coupled motion of the cardiac chambers and heart valves and provide important information about cardiac function. However, clinical flow imaging remains limited by exam times, noise, resolution,…
Malfunction of the system which regulates the bloodflow in the brain is a major cause of stroke and dementia, costing many lives and many billions of pounds each year in the UK alone. This regulatory system, known as cerebral…
Determining brain hemodynamics plays a critical role in the diagnosis and treatment of various cerebrovascular diseases. In this work, we put forth a physics-informed deep learning framework that augments sparse clinical measurements with…
Among the major factors controlling the cerebral blood flow (CBF) - cerebral perfusion pressure, arterial partial pressure of oxygen (PaO2), cerebral metabolism, arterial partial pressure of carbon dioxide (PaCO2), and cardiac output, the…
Hemodynamics in the aorta from computational fluid dynamics (CFD) simulations can provide a comprehensive analysis of relevant cardiovascular diseases. Coupling the three-element Windkessel model with the patient-specific CFD simulation to…
Dynamic cerebral autoregulation, that is the transient response of cerebral blood flow to changes in arterial blood pressure, is currently assessed using a variety of different time series methods and data collection protocols. In the…
Computational fluid dynamics (CFD) based simulation of coronary blood flow provides valuable hemodynamic markers, such as pressure gradients, for diagnosing coronary artery disease (CAD). However, CFD is computationally expensive,…
Cerebral hemodynamics is fundamentally regulated by the Circle of Willis (CoW), which redistributes flow through communicating arteries to stabilize perfusion under anatomical variations and vascular stenosis. In this study, we develop a…
Cerebral aneurysms are pathological dilations of intracranial arteries that can rupture with devastating consequences, including subarachnoid hemorrhage, stroke, and death. Accumulating evidence indicates that local hemodynamic forces play…
As autonomous systems become increasingly prevalent in daily life, ensuring their safety is paramount. Control Barrier Functions (CBFs) have emerged as an effective tool for guaranteeing safety; however, manually designing them for specific…
A healthy human brain is perfused with blood flowing laminarly through cerebral vessels, providing brain tissue with substrates such as oxygen and glucose. Under normal conditions, cerebral blood flow is controlled by autoregulation as well…
Local hemodynamic forces play an important role in determining the functional significance of coronary arterial stenosis and understanding the mechanism of coronary disease progression. Computational fluid dynamics (CFD) have been widely…
Coronary heart disease (CHD) remains a leading cause of mortality worldwide. This study introduces a novel approach that integrates patient-specific Multi-slice CT scans into CAD models, using a one-dimensional numerical framework to assess…
It is shown that the dependence of the cerebral blood flow (CBF) on mean arterial blood pressure (MABP) can be described with a simple model having the following assumptions. Below certain MABP (denoted as MABP1) there are no autoregulatory…
Cerebral autoregulation refers to regulation mechanisms that aim to maintain cerebral blood flow approximately constant. It is often assessed by autoregulation index (ARI), which uses arterial blood pressure and cerebral blood flow velocity…