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Genomics is changing our understanding of humans, evolution, diseases, and medicines to name but a few. As sequencing technology is developed collecting DNA sequences takes less time thereby generating more genetic data every day. Today the…

定量方法 · 定量生物学 2020-07-29 Sahand Salamat , Tajana Rosing

Genome sequence analysis plays a pivotal role in enabling many medical and scientific advancements in personalized medicine, outbreak tracing, and forensics. However, the analysis of genome sequencing data is currently bottlenecked by the…

硬件体系结构 · 计算机科学 2021-11-04 Damla Senol Cali

Genome sequence analysis has enabled significant advancements in medical and scientific areas such as personalized medicine, outbreak tracing, and the understanding of evolution. Unfortunately, it is currently bottlenecked by the…

Motivation: High throughput DNA sequencing (HTS) technologies generate an excessive number of small DNA segments -- called short reads -- that cause significant computational burden. To analyze the entire genome, each of the billions of…

基因组学 · 定量生物学 2020-09-29 Mohammed Alser , Hasan Hassan , Hongyi Xin , Oğuz Ergin , Onur Mutlu , Can Alkan

Genome sequencing has become a central focus in computational biology. A genome study typically begins with sequencing, which produces millions to billions of short DNA fragments known as reads. Read mapping aligns these reads to a…

Motivation: Read mapping is a computationally expensive process and a major bottleneck in genomics analyses. The performance of read mapping is mainly limited by the performance of three key computational steps: Index Querying, Seed…

硬件体系结构 · 计算机科学 2023-10-02 Julien Eudine , Mohammed Alser , Gagandeep Singh , Can Alkan , Onur Mutlu

Convolutional Neural Networks (CNNs) are widely used in deep learning applications, e.g. visual systems, robotics etc. However, existing software solutions are not efficient. Therefore, many hardware accelerators have been proposed…

机器学习 · 计算机科学 2021-09-08 Sasindu Wijeratne , Sandaruwan Jayaweera , Mahesh Dananjaya , Ajith Pasqual

This work presents a novel reconfigurable architecture for Low Latency Graph Neural Network (LL-GNN) designs for particle detectors, delivering unprecedented low latency performance. Incorporating FPGA-based GNNs into particle detectors…

硬件体系结构 · 计算机科学 2024-01-19 Zhiqiang Que , Hongxiang Fan , Marcus Loo , He Li , Michaela Blott , Maurizio Pierini , Alexander Tapper , Wayne Luk

Motivation: Despite significant advances in Third-Generation Sequencing (TGS) technologies, Next-Generation Sequencing (NGS) technologies remain dominant in the current sequencing market. This is due to the lower error rates and richer…

信息论 · 计算机科学 2023-04-04 Jia Wang , Yi Niu , Tianyi Xu , Mingming Ma , Dahua Gao , Guangming Shi

Calculating the similarities between a pair of genomic sequences is one of the most fundamental computational steps in genomic analysis. This step -- called sequence alignment -- is the computational bottleneck because: (1) it is…

基因组学 · 定量生物学 2019-10-10 Mohammed H K Alser

The proliferation of high-throughput sequencing machines ensures rapid generation of up to billions of short nucleotide fragments in a short period of time. This massive amount of sequence data can quickly overwhelm today's storage and…

分布式、并行与集群计算 · 计算机科学 2018-11-13 Subho S. Banerjee , Mohamed El-Hadedy , Jong Bin Lim , Zbigniew T. Kalbarczyk , Deming Chen , Steve Lumetta , Ravishankar K. Iyer

Aligning millions of short DNA or RNA reads, of 75 to 250 base pairs each, to a reference genome is a significant computation problem in bioinformatics. We present a flexible and fast FPGA-based short read alignment tool. Our aligner makes…

基因组学 · 定量生物学 2018-05-02 Nathaniel McVicar , Akina Hoshino , Anna La Torre , Thomas A. Reh , Walter L. Ruzzo , Scott Hauck

High-throughput sequencing (HTS) technologies have revolutionized the field of genomics, enabling rapid and cost-effective genome analysis for various applications. However, the increasing volume of genomic data generated by HTS…

硬件体系结构 · 计算机科学 2023-06-01 Onur Mutlu , Can Firtina

Recent hardware acceleration advances have enabled powerful specialized accelerators for finite element computations, spiking neural network inference, and sparse tensor operations. However, existing approaches face fundamental limitations:…

硬件体系结构 · 计算机科学 2026-01-09 Chuanzhen Wang , Leo Zhang , Eric Liu

FPGA-based hardware accelerators for convolutional neural networks (CNNs) have obtained great attentions due to their higher energy efficiency than GPUs. However, it is challenging for FPGA-based solutions to achieve a higher throughput…

分布式、并行与集群计算 · 计算机科学 2017-06-09 Yixing Li , Zichuan Liu , Kai Xu , Hao Yu , Fengbo Ren

Graph neural networks (GNNs) have recently exploded in popularity thanks to their broad applicability to ubiquitous graph-related problems such as quantum chemistry, drug discovery, and high energy physics. However, meeting demand for novel…

机器学习 · 计算机科学 2022-01-24 Stefan Abi-Karam , Yuqi He , Rishov Sarkar , Lakshmi Sathidevi , Zihang Qiao , Cong Hao

FPGA is appropriate for fix-point neural networks computing due to high power efficiency and configurability. However, its design must be intensively refined to achieve high performance using limited hardware resources. We present an…

硬件体系结构 · 计算机科学 2022-01-03 Qingyang Yi , Heming Sun , Masahiro Fujita

With the advance in genome sequencing technology, the lengths of deoxyribonucleic acid (DNA) sequencing results are rapidly increasing at lower prices than ever. However, the longer lengths come at the cost of a heavy computational burden…

分布式、并行与集群计算 · 计算机科学 2024-03-12 Seongyeon Park , Junguk Hong , Jaeyong Song , Hajin Kim , Youngsok Kim , Jinho Lee

Mini-batch inference of Graph Neural Networks (GNNs) is a key problem in many real-world applications. Recently, a GNN design principle of model depth-receptive field decoupling has been proposed to address the well-known issue of…

分布式、并行与集群计算 · 计算机科学 2023-01-05 Bingyi Zhang , Hanqing Zeng , Viktor Prasanna

Acceleration of Convolutional Neural Network (CNN) on edge devices has recently achieved a remarkable performance in image classification and object detection applications. This paper proposes an efficient and scalable CNN-based SoC-FPGA…

硬件体系结构 · 计算机科学 2022-07-29 Azzam Alhussain , Mingjie Lin
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