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Genome-wide association studies (GWAS) have emerged as a rich source of genetic clues into disease biology, and they have revealed strong genetic correlations among many diseases and traits. Some of these genetic correlations may reflect…

统计方法学 · 统计学 2018-11-28 Luke J. O'Connor , Alkes L. Price

This paper explores the potential of the transformer models for learning Granger causality in networks with complex nonlinear dynamics at every node, as in neurobiological and biophysical networks. Our study primarily focuses on a…

机器学习 · 计算机科学 2025-10-21 Ziyu Lu , Anika Tabassum , Shruti Kulkarni , Lu Mi , J. Nathan Kutz , Eric Shea-Brown , Seung-Hwan Lim

Background: A therapeutic intervention in psychiatry can be viewed as an attempt to influence the brain's large-scale, dynamic network state transitions underlying cognition and behavior. Building on connectome-based graph analysis and…

Human nonverbal emotional communication in dyadic dialogs is a process of mutual influence and adaptation. Identifying the direction of influence, or cause-effect relation between participants is a challenging task, due to two main…

计算机视觉与模式识别 · 计算机科学 2018-10-30 Lea Müller , Maha Shadaydeh , Martin Thümmel , Thomas Kessler , Dana Schneider , Joachim Denzler

Graph neural networks (GNNs) have been developed to model the relationship between regions of interest (ROIs) in brains and have shown significant improvement in detecting brain diseases. However, most of these frameworks do not consider…

机器学习 · 计算机科学 2025-06-23 Falih Gozi Febrinanto , Adonia Simango , Chengpei Xu , Jingjing Zhou , Jiangang Ma , Sonika Tyagi , Feng Xia

Granger causality is a fundamental technique for causal inference in time series data, commonly used in the social and biological sciences. Typical operationalizations of Granger causality make a strong assumption that every time point of…

机器学习 · 计算机科学 2020-11-23 Chainarong Amornbunchornvej , Elena Zheleva , Tanya Y. Berger-Wolf

Explaining underlying causes or effects about events is a challenging but valuable task. We define a novel problem of generating explanations of a time series event by (1) searching cause and effect relationships of the time series with…

计算与语言 · 计算机科学 2018-04-26 Dongyeop Kang , Varun Gangal , Ang Lu , Zheng Chen , Eduard Hovy

While correlation measures are used to discern statistical relationships between observed variables in almost all branches of data-driven scientific inquiry, what we are really interested in is the existence of causal dependence. Designing…

机器学习 · 计算机科学 2014-06-26 Ishanu Chattopadhyay

Introduction: To leverage functionality and clinical relevance into understanding systems biology, one needs to understand the pathway of the genetic effects on risk factors/disease through intermediate molecular levels, such as…

基因组学 · 定量生物学 2018-09-14 Azam Yazdani , Akram Yazdani , Philip L. Lorenzi , Ahmad Samiei

Introduced more than a half century ago, Granger causality has become a popular tool for analyzing time series data in many application domains, from economics and finance to genomics and neuroscience. Despite this popularity, the validity…

统计方法学 · 统计学 2021-05-10 Ali Shojaie , Emily B. Fox

Most of the metrics used for detecting a causal relationship among multiple time series ignore the effects of practical measurement impairments, such as finite sample effects, undersampling and measurement noise. It has been shown that…

统计方法学 · 统计学 2023-04-03 Rahul Devendra , Ribhu Chopra , Kumar Appaiah

Imitation learning, which learns agent policy by mimicking expert demonstration, has shown promising results in many applications such as medical treatment regimes and self-driving vehicles. However, it remains a difficult task to interpret…

机器学习 · 计算机科学 2024-01-31 Tianxiang Zhao , Wenchao Yu , Suhang Wang , Lu Wang , Xiang Zhang , Yuncong Chen , Yanchi Liu , Wei Cheng , Haifeng Chen

We analyze by means of Granger causality the effect of synergy and redundancy in the inference (from time series data) of the information flow between subsystems of a complex network. Whilst we show that fully conditioned Granger causality…

定量方法 · 定量生物学 2015-06-19 Sebastiano Stramaglia , Jesus M. Cortes , Daniele Marinazzo

Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex traits, and some variants are shown to be associated with multiple complex traits. Genetic covariance between two traits is defined…

统计方法学 · 统计学 2023-10-06 Jianqiao Wang , Sai Li , Hongzhe Li

Which joint interactions in the human gait cycle can be used as biometric characteristics? Most current methods on gait recognition suffer from the lack of interpretability. We propose an interpretable feature representation of gait…

计算机视觉与模式识别 · 计算机科学 2022-12-09 Michal Balazia , Katerina Hlavackova-Schindler , Petr Sojka , Claudia Plant

A challenging problem when studying a dynamical system is to find the interdependencies among its individual components. Several algorithms have been proposed to detect directed dynamical influences between time series. Two of the most used…

数据分析、统计与概率 · 物理学 2015-09-09 Alessandro Montalto , Sebastiano Stramaglia , Luca Faes , Giovanni Tessitore , Roberto Prevete , Daniele Marinazzo

We address the problem of learning Granger causality from asynchronous, interdependent, multi-type event sequences. In particular, we are interested in discovering instance-level causal structures in an unsupervised manner. Instance-level…

机器学习 · 计算机科学 2024-03-01 Dongxia Wu , Tsuyoshi Idé , Aurélie Lozano , Georgios Kollias , Jiří Navrátil , Naoki Abe , Yi-An Ma , Rose Yu

Objectives: We develop a framework for the analysis of synergy and redundancy in the pattern of information flow between subsystems of a complex network. Methods: The presence of redundancy and/or synergy in multivariate time series data…

Understanding causal relationships within Gene Regulatory Networks (GRNs) is essential for unraveling the gene interactions in cellular processes. However, causal discovery in GRNs is a challenging problem for multiple reasons including the…

人工智能 · 计算机科学 2023-10-06 Trang Nguyen , Alexander Tong , Kanika Madan , Yoshua Bengio , Dianbo Liu

The problem of estimating high-dimensional network models arises naturally in the analysis of many physical, biological and socio-economic systems. Examples include stock price fluctuations in financial markets and gene regulatory networks…

统计方法学 · 统计学 2013-10-09 Sumanta Basu , Ali Shojaie , George Michailidis