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Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects cognitive functions such as memory, thinking, and behavior. In this disease, there is a critical phase, mild cognitive impairment, that is really…

信号处理 · 电气工程与系统科学 2024-04-02 Arezoo Borji , Taha-Hossein Hejazi , Abbas Seifi

INTRODUCTION: Heterogeneity in the progression of Alzheimer's disease makes it challenging to predict the rate of cognitive and functional decline for individual patients. Tools for short-term prediction could help enrich clinical trial…

定量方法 · 定量生物学 2021-01-22 Neda Shafiee , Mahsa Dadar , Simon Ducharme , D. Louis Collins

The early signs of cognitive decline are often noticeable in conversational speech, and identifying those signs is crucial in dealing with later and more serious stages of neurodegenerative diseases. Clinical detection is costly and…

Alzheimer's Disease (AD) is a severe brain disorder, destroying memories and brain functions. AD causes chronically, progressively, and irreversibly cognitive declination and brain damages. The reliable and effective evaluation of early…

图像与视频处理 · 电气工程与系统科学 2021-01-07 Kuo Yang , Emad A. Mohammed

Cognitive impairments in older adults represent a significant public health concern, necessitating accurate diagnostic and monitoring strategies. In this study, the principal cognitive and neuropsychological evaluations employed for the…

神经元与认知 · 定量生物学 2024-02-23 Chuang Li , Rubing Lin , Yantong Liu , Yichen Wei

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that leads to dementia, and early intervention can greatly benefit from analyzing linguistic abnormalities. In this work, we explore the potential of Large Language Models…

计算与语言 · 计算机科学 2025-12-23 Chuyuan Li , Raymond Li , Thalia S. Field , Giuseppe Carenini

We present two multimodal fusion-based deep learning models that consume ASR transcribed speech and acoustic data simultaneously to classify whether a speaker in a structured diagnostic task has Alzheimer's Disease and to what degree,…

计算与语言 · 计算机科学 2021-07-01 Morteza Rohanian , Julian Hough , Matthew Purver

Quantum machine learning is a new research field combining quantum information science and machine learning. Quantum computing technologies appear to be particularly well-suited for addressing problems in the health sector efficiently. They…

新兴技术 · 计算机科学 2024-12-24 Giacomo Cappiello , Filippo Caruso

Diagnosing Autism Spectrum Disorder (ASD) is a challenging problem, and is based purely on behavioral descriptions of symptomology (DSM-5/ICD-10), and requires informants to observe children with disorder across different settings (e.g.…

神经元与认知 · 定量生物学 2020-03-04 Taban Eslami , Joseph S. Raiker , Fahad Saeed

Speech-comprehension difficulties are common among older people. Standard speech tests do not fully capture such difficulties because the tests poorly resemble the context-rich, story-like nature of ongoing conversation and are typically…

计算与语言 · 计算机科学 2025-03-04 Björn Herrmann

Early detection of dementia is crucial to devise effective interventions. Comprehensive cognitive tests, while being the most accurate means of diagnosis, are long and tedious, thus limiting their applicability to a large population,…

计算机视觉与模式识别 · 计算机科学 2025-05-30 Anusha A. S. , Uma Ranjan , Medha Sharma , Siddharth Dutt

Aging associated brain decline often result in some kind of dementia. Even when this is a complex brain disorder a physical model can be used in order to describe its general behavior. This model is based in first principles. A…

神经元与认知 · 定量生物学 2016-07-22 Oscar Sotolongo-Costa , L. M. Gaggero-Sager , J. T. Becker , F. Maestú , O. Sotolongo-Grau

The ageing population trend is correlated with an increased prevalence of acquired cognitive impairments such as dementia. Although there is no cure for dementia, a timely diagnosis helps in obtaining necessary support and appropriate…

计算机视觉与模式识别 · 计算机科学 2021-01-06 Xing Liang , Anastassia Angelopoulou , Epaminondas Kapetanios , Bencie Woll , Reda Al-batat , Tyron Woolfe

Objective Alzheimer disease (AD) is the most common cause of dementia, a syndrome characterized by cognitive impairment severe enough to interfere with activities of daily life. We aimed to conduct a systematic literature review (SLR) of…

定量方法 · 定量生物学 2021-08-31 Sayantan Kumar , Inez Oh , Suzanne Schindler , Albert M Lai , Philip R O Payne , Aditi Gupta

Deficits in working memory, which includes both the ability to learn and to retain information short-term, are a hallmark of many cognitive disorders. Our study analyzes data from a neuroscience experiment on animal subjects, where…

应用统计 · 统计学 2025-12-23 Maria Laura Battagliola , Laura J. Benoit , Sarah Canetta , Shizhe Zhang , R. Todd Ogden

Multi-modal biological, imaging, and neuropsychological markers have demonstrated promising performance for distinguishing Alzheimer's disease (AD) patients from cognitively normal elders. However, it remains difficult to early predict when…

计算机视觉与模式识别 · 计算机科学 2019-01-08 Hongming Li , Yong Fan

Embedded in any speech signal is a rich combination of cognitive, neuromuscular and physiological information. This richness makes speech a powerful signal in relation to a range of different health conditions, including major depressive…

声音 · 计算机科学 2022-04-04 Salvatore Fara , Stefano Goria , Emilia Molimpakis , Nicholas Cummins

Healthcare datasets present many challenges to both machine learning and statistics as their data are typically heterogeneous, censored, high-dimensional and have missing information. Feature selection is often used to identify the…

机器学习 · 计算机科学 2022-07-06 Annette Spooner , Gelareh Mohammadi , Perminder S. Sachdev , Henry Brodaty , Arcot Sowmya

Brain positron emission tomography (PET) imaging is broadly used in research and clinical routines to study, diagnose, and stage Alzheimer's disease (AD). However, its potential cannot be fully exploited yet due to the lack of portable…

图像与视频处理 · 电气工程与系统科学 2025-01-16 Eléonore V. Lieffrig , Takuya Toyonaga , Jiazhen Zhang , John A. Onofrey

Speech impairments resulting from congenital disorders, such as cerebral palsy, down syndrome, or apert syndrome, as well as acquired brain injuries due to stroke, traumatic accidents, or tumors, present major challenges to automatic speech…

音频与语音处理 · 电气工程与系统科学 2026-03-17 Niclas Pokel , Pehuén Moure , Roman Boehringer , Shih-Chii Liu , Yingqiang Gao
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