相关论文: The Multi-biophysical nature of Computation in bra…

Comprehending the nature of action potentials is fundamental to our understanding of the functioning of nervous systems in general. Here we consider their evolution and describe their functions of communication, modulation and computation…

Conventionally it is assumed that the nerve impulse is an electrical process based upon the observation that electrical stimuli produce an action potential as defined by Hodgkin Huxley (1952) (HH). Consequently, investigations into the…

We demonstrate that our recently developed theory of electric field wave propagation in anisotropic and inhomogeneous brain tissues, which has been shown to explain a broad range of observed coherent synchronous brain electrical processes,…

In an ongoing debate on the physical nature of the action potential, one group adheres to the electrical model of Hodgkin and Huxley, while the other describes the action potential as a non-linear acoustic pulse propagating within an…

We suggest that the propagation of the action potential is driven by a pressure pulse propagating in the axoplasm along the axon length. The pressure pulse mechanically activates Na ion channels embedded in the axon membrane. This…

Many studies have shown that a mechanical displacement of the axonal membrane accompanies the electrical pulse defining the Action Potential (AP). Despite a large and diverse body of experimental evidence, there is no theoretical consensus…

The result of computational operations performed at the single cell level are coded into sequences of action potentials (APs). In the cerebral cortex, due to its columnar organization, large number of neurons are involved in any individual…

Objective: In cochlear implant users with residual acoustic hearing, compound action potentials (CAPs) can be evoked by acoustic (aCAP) or electric (eCAP) stimulation and recorded through the electrodes of the implant. We propose a novel…

In a succession of articles published over 65 years ago, Sir Alan Lloyd Hodgkin and Sir Andrew Fielding Huxley established what now forms our physical understanding of excitation in nerve, and how the axon conducts the action potential.…

Starting from the concept of binary interactions between pairs of particles, a kinetic framework for the description of the action potential dynamics on a neural network is proposed. It consists of two coupled levels: the description of a…

In the context of multi-agent systems of binary interacting particles, a kinetic model for action potential dynamics on a neural network is proposed, accounting for heterogeneity in the neuron-to-neuron connections, as well as in the brain…

Here we provide evidence that the fundamental basis of nervous communication is derived from a pressure pulse/soliton capable of computation with sufficient temporal precision to overcome any processing errors. Signalling and computing…

Action potential generation underlies some of the most consequential dynamical systems on Earth, from brains to hearts. It is therefore interesting to develop synthetic cell-free systems, based on the same molecular mechanisms, which may…

Axons functionally link the somato-dendritic compartment to synaptic terminals. Structurally and functionally diverse, they accomplish a central role in determining the delays and reliability with which neuronal ensembles communicate. By…

Fundamentally, action potentials in the squid axon are consequence of the entrance of sodium ions during the depolarization of the rising phase of the spike mediated by the outflow of potassium ions during the hyperpolarization of the…

The soliton wave model of action potentials, and the proposal of induced lipid pores, are potentially paradigm shifting ideas which challenge accepted views of the Hodgkin-Huxley model and of protein-based ion channels. These two proposals…

In this paper the authors extend [1] and provide more details of how the brain may act like a quantum computer. In particular, positing the difference between voltages on two axons as the environment for ions undergoing spatial…

Central neurons initiate action potentials (APs) in the axon initial segment (AIS), a compartment characterized by a high concentration of voltage-dependent ion channels and specialized cytoskeletal anchoring proteins arranged in a regular…

It is a common incident in nature, that two waves or pulses run into each other head-on. The outcome of such an event is of special interest, because it allows conclusions about the underlying physical nature of the pulses. The present…

The artificial axon is an excitable node built with the basic biomolecular components and supporting action potentials. Here we demonstrate coincidence firing (the AND operation) and other basic electrophysiology features such as increasing…