相关论文: A Large-Scale Benchmark of Cross-Modal Learning fo…

Motivation. Understanding the pan-cancer mutational landscape offers critical insights into the molecular mechanisms underlying tumorigenesis. While patient-level machine learning techniques have been widely employed to identify tumor…

Recently, the cross-modal pre-training task has been a hotspot because of its wide application in various down-streaming researches including retrieval, captioning, question answering and so on. However, exiting methods adopt a one-stream…

Characterizing the transcriptome architecture of the human brain is fundamental in gaining an understanding of brain function and disease. A number of recent studies have investigated patterns of brain gene expression obtained from an…

Generative Adversarial Networks (GANs) have been at the forefront of image synthesis, especially in medical fields like histopathology, where they help address challenges such as data scarcity, patient privacy, and class imbalance. However,…

The rapid development of spatial transcriptomics (ST) offers new opportunities to explore the gene expression patterns within the spatial microenvironment. Current research integrates pathological images to infer gene expression, addressing…

Multilayer-perceptrons (MLP) are known to struggle with learning functions of high-frequencies, and in particular cases with wide frequency bands. We present a spatially adaptive progressive encoding (SAPE) scheme for input signals of MLP…

Accurate molecular subtype classification is essential for personalized breast cancer treatment, yet conventional immunohistochemical analysis relies on invasive biopsies and is prone to sampling bias. Although dynamic contrast-enhanced…

Image-to-point cross-modal learning has emerged to address the scarcity of large-scale 3D datasets in 3D representation learning. However, current methods that leverage 2D data often result in large, slow-to-train models, making them…

Cancer pathological analysis requires modeling tumor heterogeneity across multiple modalities, primarily through transcriptomics and whole slide imaging (WSI), along with their spatial relations. On one hand, bulk transcriptomics and WSI…

Learning aligned multimodal embeddings from weakly paired, label-free corpora is challenging: pipelines often provide only pre-extracted features, clips contain multiple events, and spurious co-occurrences. We propose HSC-MAE (Hierarchical…

Intelligent medical diagnosis has shown remarkable progress based on the large-scale datasets with precise annotations. However, fewer labeled images are available due to significantly expensive cost for annotating data by experts. To fully…

With the recent promising results of contrastive learning in the self-supervised learning paradigm, supervised contrastive learning has successfully extended these contrastive approaches to supervised contexts, outperforming cross-entropy…

Large-scale multi-modal contrastive pre-training has demonstrated great utility to learn transferable features for a range of downstream tasks by mapping multiple modalities into a shared embedding space. Typically, this has employed…

Tasks ranging from sleep staging to clinical diagnosis traditionally rely on standard polysomnography (PSG) devices, bedside monitors and wearable devices, which capture diverse nocturnal biosignals (e.g., EEG, EOG, ECG, SpO$_2$). However,…

Adversarial attacks pose significant challenges for vision models in critical fields like healthcare, where reliability is essential. Although adversarial training has been well studied in natural images, its application to biomedical and…

With the emergence of advanced spatial transcriptomic technologies, there has been a surge in research papers dedicated to analyzing spatial transcriptomics data, resulting in significant contributions to our understanding of biology. The…

Integrating molecular, morphological, and clinical data is essential for basic and translational biomedical research, yet systematic frameworks for jointly modeling these modalities remain limited. Here we present Haiku, a tri-modal…

Spatial-temporal forecasting is crucial and widely applicable in various domains such as traffic, energy, and climate. Benefiting from the abundance of unlabeled spatial-temporal data, self-supervised methods are increasingly adapted to…

Training specific deep learning models for particular tasks is common across various domains within seismology. However, this approach encounters two limitations: inadequate labeled data for certain tasks and limited generalization across…

Recent advancements in Spatial Transcriptomics (ST) technology have facilitated detailed gene expression analysis within tissue contexts. However, the high costs and methodological limitations of ST necessitate a more robust predictive…