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Much evidence in comparative effectiveness research is based on observational studies. Researchers who conduct observational studies typically assume that there are no unobservable differences between the treated and control groups.…

应用统计 · 统计学 2020-01-23 Luke Keele , Stephen O'Neill , Richard Grieve

The standard paradigm for confirmatory clinical trials is to compare experimental treatments with a control, for example the standard of care or a placebo. However, it is not always the case that a suitable control exists. Efficient…

统计方法学 · 统计学 2024-10-29 Thomas Burnett , Thomas Jaki

Multiple hypothesis testing (MHT) frequently arises in scientific inquiries, and concurrent testing of multiple hypotheses inflates the risk of Type-I errors or false positives, rendering MHT corrections essential. This paper addresses MHT…

We investigate the multiplicity model with m values of some test statistic independently drawn from a mixture of no effect (null) and positive effect (alternative), where we seek to identify, the alternative test results with a controlled…

统计方法学 · 统计学 2024-02-06 Zhiwen Jiang , Stephan Morgenthaler

Large language models (LLMs) trained on internet-scale corpora can exhibit systematic biases that increase the probability of unwanted behavior. In this study, we examined potential biases towards synthetic vs. biological technological…

计算与语言 · 计算机科学 2026-03-11 Trent R Northen , Mingxun Wang

The estimation of heterogeneous treatment effects in the potential outcome setting is biased when there exists model misspecification or unobserved confounding. As these biases are unobservable, what model to use when remains a critical…

统计方法学 · 统计学 2024-05-09 Shonosuke Sugasawa , Kosaku Takanashi , Kenichiro McAlinn , Edoardo M. Airoldi

Publication bias occurs when the publication of research results depends not only on the quality of the research but also on its nature and direction. The consequence is that published studies may not be truly representative of all valid…

统计方法学 · 统计学 2020-02-13 Chuan Hong , Jing Zhang , Yang Li , Elena Elia , Richard Riley , Yong Chen

A topological multiple testing scheme for one-dimensional domains is proposed where, rather than testing every spatial or temporal location for the presence of a signal, tests are performed only at the local maxima of the smoothed observed…

统计理论 · 数学 2012-03-15 Armin Schwartzman , Yulia Gavrilov , Robert J. Adler

The use of mutual information as a similarity measure in agglomerative hierarchical clustering (AHC) raises an important issue: some correction needs to be applied for the dimensionality of variables. In this work, we formulate the decision…

机器学习 · 统计学 2016-08-07 Guillaume Marrelec , Arnaud Messé , Pierre Bellec

The objective of Bayesian inference is often to infer, from data, a probability measure for a random variable that can be used as input for Monte Carlo simulation. When datasets for Bayesian inference are small, a principle challenge is…

统计计算 · 统计学 2018-03-29 Jiaxin Zhang , Michael D. Shields

Outcome Reporting Bias (ORB) poses significant threats to the validity of meta-analytic findings. It occurs when researchers selectively report outcomes based on the significance or direction of results, potentially leading to distorted…

统计方法学 · 统计学 2025-07-17 Alessandra Gaia Saracini , Leonhard Held

Biometric data is pervasively captured and analyzed. Using modern machine learning approaches, identity and attribute inferences attacks have proven high accuracy. Anonymizations aim to mitigate such disclosures by modifying data in a way…

密码学与安全 · 计算机科学 2024-07-10 Julian Todt , Simon Hanisch , Thorsten Strufe

Recent results concerning asymptotic Bayes-optimality under sparsity (ABOS) of multiple testing procedures are extended to fairly generally distributed effect sizes under the alternative. An asymptotic framework is considered where both the…

Indirect comparisons have been increasingly used to compare data from different sources such as clinical trials and observational data in, e.g., a disease registry. To adjust for population differences between data sources,…

统计方法学 · 统计学 2021-07-27 Jixian Wang

Parallel evolutionary algorithms (PEAs) have been studied for reducing the execution time of evolutionary algorithms by utilizing parallel computing. An asynchronous PEA (APEA) is a scheme of PEAs that increases computational efficiency by…

神经与进化计算 · 计算机科学 2026-01-21 Tomohiro Harada

As computer vision systems become more widely deployed, there is increasing concern from both the research community and the public that these systems are not only reproducing but amplifying harmful social biases. The phenomenon of bias…

计算机视觉与模式识别 · 计算机科学 2023-05-31 Dora Zhao , Jerone T. A. Andrews , Alice Xiang

Similarity choice data occur when humans make choices among alternatives based on their similarity to a target, e.g., in the context of information retrieval and in embedding learning settings. Classical metric-based models of similarity…

Matching is a popular nonparametric covariate adjustment strategy in empirical health services research. Matching helps construct two groups comparable in many baseline covariates but different in some key aspects under investigation. In…

应用统计 · 统计学 2023-08-17 Chang Chen , Zhiyu Qian , Bo Zhang

Insurance products frequently cover significant claims arising from a variety of sources. To model losses from these products accurately, actuarial models must account for high-severity claims. A widely used strategy is to apply a mixture…

统计方法学 · 统计学 2025-04-30 Sébastien Jessup , Mélina Mailhot , Mathieu Pigeon

We analyze control of the familywise error rate (FWER) in a multiple testing scenario with a great many null hypotheses about the distribution of a high-dimensional random variable among which only a very small fraction are false, or…

统计方法学 · 统计学 2015-09-15 Kamel Lahouel , Donald Geman , Laurent Younes