相关论文: Breaking the picomolar barrier in lateral flow ass…

Lateral flow (LF) immunoassays are one of the most prevalent point-of-care (POC) diagnostics due to their simplicity, low cost, and robust operation. A common criticism of LF tests is that they have poor detection limits compared to…

The early detection and precise diagnosis of liver tumors are tasks of critical clinical value, yet they pose significant challenges due to the high heterogeneity and variability of liver tumors. In this work, a precise LIver tumor…

We present the deepest study to date of the Lya luminosity function (LF) in a blank field using blind integral field spectroscopy from MUSE. We constructed a sample of 604 Lya emitters (LAEs) across the redshift range 2.91 < z < 6.64 using…

Plastic nanoparticles present technological opportunities and environmental concerns, but measurement challenges impede product development and hazard assessment. To meet these challenges, we advance a lateral nanoflow assay that integrates…

A new sightline geometry for the fast-ion D-alpha (FIDA) diagnostic on the Large Helical Device (LHD) has been confirmed to measure signals for high-energy fast ions produced by negative-ion neutral beam injection. The newly installed…

Lateral flow immunoassays (LFIA) are widely used worldwide for the detection of different analytes because they combine multiple advantages such as low production cost, simplicity, and portability, which allows biomarkers detection without…

Immunoaffinity-based liquid biopsies of circulating tumor cells (CTCs) hold great promise for cancer management, but typically suffer from low throughput, relative complexity and post-processing limitations. Here we address these issues…

A wide range of methods currently exist for testing the presence of malaria, each with its own advantages and disadvantages. New technologies are urgently needed to develop more effective diagnosis tools to fight and eradicate malaria.…

Successful integration of point-of-care testing (POCT) into clinical settings requires improved assay sensitivity and precision to match laboratory standards. Here, we show how innovations in amplified biosensing, imaging, and data…

Motivation: Flow Injection Analysis coupled to High-Resolution Mass Spectrometry (FIA-HRMS) is a promising approach for high-throughput metabolomics. FIA-HRMS data, however, cannot be preprocessed with current software tools which rely on…

Lyman alpha (Lya) emission lines should be attenuated in a neutral intergalactic medium (IGM). Therefore the visibility of Lya emitters at high redshifts can serve as a valuable probe of reionization at about the 50% level. We present an…

We describe a novel cancer diagnostic method based on plasma denaturation profiles obtained by a non-conventional use of Differential Scanning Fluorimetry. We show that 84 glioma patients and 63 healthy controls can be automatically…

We present the photometric determination of the bright-end (L_Lya>10^43.5 erg/s) of the Lya luminosity function (LF) within four redshifts windows in the interval 2.2<z<3.3. Our work is based on the Javalambre Photometric Local Universe…

We present numerical studies, nano-fabrication and optical characterization of bowtie nanoantennas demonstrating their superior performance with respect to the electric field enhancement as compared to other Au nanoparticle shapes. For…

Generation of highly collimated monoenergetic relativistic ion beams is one of the most challenging and promising areas in ultra-intense laser-matter interactions because of the numerous scientific and technological applications that…

Leukocyte differential test is a widely performed clinical procedure for screening infectious diseases. Existing hematology analyzers require labor-intensive work and a panel of expensive reagents. Here we report an artificial-intelligence…

Using wide field narrow-band surveys, we provide a new measurement of the $z=6.6$ Lyman-$\alpha$ Emitter (LAE) luminosity function (LF), which constraints the bright end for the first time. We use a combination of archival narrow-band NB921…

Malaria remains a major health threat in low-resource regions and rapid diagnostic tests often lack the sensitivity required for early detection. To address this and help establish more sensitive testing devices, we develop a predictive…

We present deep spectroscopic observations of a Lyman-alpha emitter (LAE) candidate at z ~ 7.7 using the infrared spectrograph LUCI on the 2 x 8.4m Large Binocular Telescope (LBT). The candidate is the brightest among the four z ~ 7.7 LAE…

We report the first direct and robust measurement of the faint-end slope of the Lyman-alpha emitter (LAE) luminosity function at z = 5.7. Candidate LAEs from a low-spectral-resolution blind search with IMACS on Magellan-Baade were targeted…