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Multimodal imaging has transformed neuroscience research. While it presents unprecedented opportunities, it also imposes serious challenges. Particularly, it is difficult to combine the merits of the interpretability attributed to a simple…

统计方法学 · 统计学 2021-11-25 Xiaowu Dai , Lexin Li

The colocation of individuals in different environments is an important prerequisite for exposure to infectious diseases on a social network. Standard epidemic models fail to capture the potential complexity of this scenario by (1)…

Non-significant randomized control trials can hide subgroups of good responders to experimental drugs, thus hindering subsequent development. Identifying such heterogeneous treatment effects is key for precision medicine and many post-hoc…

统计方法学 · 统计学 2024-01-24 Valentine Perrin , Nathan Noiry , Nicolas Loiseau , Alex Nowak

Heterogeneous treatment effects can be very important in the analysis of randomized clinical trials. Heightened risks or enhanced benefits may exist for particular subsets of study subjects. When the heterogeneous treatment effects are…

统计方法学 · 统计学 2025-07-25 Richard A. Berk , Matthew Olson , Andreas Buja , Aurelie Ouss

Heterogeneous networks not only present a challenge of heterogeneity in the types of nodes and relations, but also the attributes and content associated with the nodes. While recent works have looked at representation learning on…

社会与信息网络 · 计算机科学 2018-05-15 Chuxu Zhang , Ananthram Swami , Nitesh V. Chawla

In this paper we propose a heterogeneous modeling framework which achieves individual-wise feature selection and individualized covariates' effects subgrouping simultaneously. In contrast to conventional model selection approaches, the new…

统计方法学 · 统计学 2019-06-11 Xiwei Tang , Fei Xue , Annie Qu

Current machine learning models aiming to predict sepsis from Electronic Health Records (EHR) do not account for the heterogeneity of the condition, despite its emerging importance in prognosis and treatment. This work demonstrates the…

定量方法 · 定量生物学 2020-11-24 Zina Ibrahim , Honghan Wu , Ahmed Hamoud , Lukas Stappen , Richard Dobson , Andrea Agarossi

Estimation of heterogeneous treatment effects is an active area of research. Most of the existing methods, however, focus on estimating the conditional average treatment effects of a single, binary treatment given a set of pre-treatment…

统计方法学 · 统计学 2025-05-30 Max Goplerud , Kosuke Imai , Nicole E. Pashley

Predicting (1) when the next hospital admission occurs and (2) what will happen in the next admission about a patient by mining electronic health record (EHR) data can provide granular readmission predictions to assist clinical decision…

机器学习 · 计算机科学 2021-02-05 Bhagya Hettige , Weiqing Wang , Yuan-Fang Li , Suong Le , Wray Buntine

Estimating causal effects on networks is challenging because treatments may affect both treated units and their neighbors, while network homophily induces dependence and confounding. These challenges are amplified when causal effects are…

机器学习 · 统计学 2026-05-12 Yuanchen Wu , Yubai Yuan

Estimation of division and death rates of lymphocytes in different conditions is vital for quantitative understanding of the immune system. Deuterium, in the form of deuterated glucose or heavy water, can be used to measure rates of…

种群与进化 · 定量生物学 2015-05-13 Vitaly V. Ganusov , Jose Borghans , Rob De Boer

Generative pre-training via discrete diffusion provides dense reconstruction supervision across all feature fields simultaneously, mitigating representation collapse from data sparsity in CTR prediction. However, all existing generative CTR…

信息检索 · 计算机科学 2026-05-26 Moyu Zhang , Yun Chen , Yujun Jin , Jinxin Hu , Yu Zhang , Xiaoyi Zeng

Recently, it has become progressively more evident that classic diagnostic labels are unable to reliably describe the complexity and variability of several clinical phenotypes. This is particularly true for a broad range of neuropsychiatric…

机器学习 · 计算机科学 2024-02-28 Giovanna Maria Dimitri , Simeon Spasov , Andrea Duggento , Luca Passamonti , Pietro Li`o , Nicola Toschi

We consider the task of meta-analysis in high-dimensional settings in which the data sources are similar but non-identical. To borrow strength across such heterogeneous datasets, we introduce a global parameter that emphasizes…

统计方法学 · 统计学 2022-07-01 Subha Maity , Yuekai Sun , Moulinath Banerjee

Personalized recommendation is an important class of deep-learning applications that powers a large collection of internet services and consumes a considerable amount of datacenter resources. As the scale of production-grade recommendation…

分布式、并行与集群计算 · 计算机科学 2022-03-16 Liu Ke , Udit Gupta , Mark Hempstead , Carole-Jean Wu , Hsien-Hsin S. Lee , Xuan Zhang

Uncovering the heterogeneity in the disease progression of Alzheimer's is a key factor to disease understanding and treatment development, so that interventions can be tailored to target the subgroups that will benefit most from the…

统计方法学 · 统计学 2021-10-28 Mingming Liu , Jing Yang , Yushi Liu , Bochao Jia , Yun-Fei Chen , Luna Sun , Shujie Ma

Understanding treatment heterogeneity is essential to the development of precision medicine, which seeks to tailor medical treatments to subgroups of patients with similar characteristics. One of the challenges to achieve this goal is that…

统计方法学 · 统计学 2019-08-21 Shujie Ma , Jian Huang , Zhiwei Zhang , Mingming Liu

Medicinal synergy prediction is a powerful tool in drug discovery and development that harnesses the principles of combination therapy to enhance therapeutic outcomes by improving efficacy, reducing toxicity, and preventing drug resistance.…

计算工程、金融与科学 · 计算机科学 2024-11-26 Jiawei Wu , Jun Wen , Mingyuan Yan , Anqi Dong , Shuai Gao , Ren Wang , Can Chen

Graphical models are powerful tools to investigate complex dependency structures in high-throughput datasets. However, most existing graphical models make one of the two canonical assumptions: (i) a homogeneous graph with a common network…

统计方法学 · 统计学 2023-10-31 Tsung-Hung Yao , Yang Ni , Anindya Bhadra , Jian Kang , Veerabhadran Baladandayuthapani

Medical imaging datasets often contain heterogeneous biases ranging from erroneous labels to inconsistent labeling styles. Such biases can negatively impact deep segmentation networks performance. Yet, the identification and…

计算机视觉与模式识别 · 计算机科学 2025-06-27 Samuel Joutard , Marijn Stollenga , Marc Balle Sanchez , Mohammad Farid Azampour , Raphael Prevost
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