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Deep Brain Stimulation (DBS) is a therapy widely used for treating the symptoms of neurological disorders. Electrical pulses are chronically delivered in DBS to a disease-specific brain target via a surgically implanted electrode. The…

系统与控制 · 电气工程与系统科学 2024-10-24 Anna Franziska Frigge , Elena Jiltsova , Fredrik Olsson , Dag Nyholm , Alexander Medvedev

Closed-loop neural stimulation provides novel therapies for neurological diseases such as Parkinson's disease (PD), but it is not yet clear whether artificial intelligence (AI) techniques can tailor closed-loop stimulation to individual…

机器学习 · 计算机科学 2025-07-22 Matthew J. Bryan , Felix Schwock , Azadeh Yazdan-Shahmorad , Rajesh P N Rao

Deep Reinforcement Learning (RL) is proven powerful for decision making in simulated environments. However, training deep RL model is challenging in real world applications such as production-scale health-care or recommender systems because…

机器学习 · 计算机科学 2020-02-14 Ge Liu , Rui Wu , Heng-Tze Cheng , Jing Wang , Jayden Ooi , Lihong Li , Ang Li , Wai Lok Sibon Li , Craig Boutilier , Ed Chi

Respondent-driven sampling (RDS) is widely used to study hidden or hard-to-reach populations by incentivizing study participants to recruit their social connections. The success and efficiency of RDS can depend critically on the nature of…

统计方法学 · 统计学 2025-01-06 Justin Weltz , Angela Yoon , Yichi Zhang , Alexander Volfovsky , Eric Laber

Intelligent reflecting surface (IRS) is a promising technology to assist downlink information transmissions from a multi-antenna access point (AP) to a receiver. In this paper, we minimize the AP's transmit power by a joint optimization of…

信号处理 · 电气工程与系统科学 2020-05-26 Jiaye Lin , Yuze Zou , Xiaoru Dong , Shimin Gong , Dinh Thai Hoang , Dusit Niyato

Accurate assessment of Parkinsonian tremor is vital for monitoring disease progression and evaluating treatment efficacy. We introduce a pixel-based deep learning model designed to analyse postural tremor in Parkinson's disease (PD) from…

计算机视觉与模式识别 · 计算机科学 2024-09-04 Felipe Duque-Quiceno , Grzegorz Sarapata , Yuriy Dushin , Miles Allen , Jonathan O'Keeffe

Parkinson's disease (PD) affects over ten million people worldwide. Although temporal interference (TI) and deep brain stimulation (DBS) are promising therapies, inter-individual variability limits empirical treatment selection, increasing…

Deep brain stimulation (DBS) is an established method for treating pathological conditions such as Parkinson's disease, dystonia, Tourette syndrome, and essential tremor. While the precise mechanisms which underly the effectiveness of DBS…

动力系统 · 数学 2020-07-07 Daniel Kuelbs , Jacob Dunefsky , Bharat Monga , Jeff Moehlis

This article presents a motion planning and control framework for flexible robotic manipulators, integrating deep reinforcement learning (DRL) with a nonlinear partial differential equation (PDE) controller. Unlike conventional approaches…

机器人学 · 计算机科学 2025-06-11 Amir Hossein Barjini , Seyed Adel Alizadeh Kolagar , Sadeq Yaqubi , Jouni Mattila

Deep Brain Stimulation (DBS) is a well-established neurosurgical treatment aiming at symptom alleviation in a range of neurological and psychiatric diseases. Computational models of DBS are widely used to investigate the effects of…

系统与控制 · 电气工程与系统科学 2025-11-17 Anna Franziska Frigge , Alexander Medvedev

Objective: Anemia is a frequent comorbidity in hemodialysis patients that can be successfully treated by administering erythropoiesis-stimulating agents (ESAs). ESAs dosing is currently based on clinical protocols that often do not account…

The electromagnetic inverse problem has long been a research hotspot. This study aims to reverse radar view angles in synthetic aperture radar (SAR) images given a target model. Nonetheless, the scarcity of SAR data, combined with the…

机器学习 · 计算机科学 2024-01-03 Yanni Wang , Hecheng Jia , Shilei Fu , Huiping Lin , Feng Xu

Controlling inter-area oscillation (IAO) across wide areas is crucial for the stability of modern power systems. Recent advances in deep learning, combined with the extensive deployment of phasor measurement units (PMUs) and generator…

系统与控制 · 电气工程与系统科学 2025-07-04 Siyuan Liang , Long Huo , Wenyu Qin , Xin Chen , Peiyuan Sun

Accurately estimating ground-state energies of quantum many-body systems is still a challenging computational task because of the exponential growth of the Hilbert space with the system size. Sample-based diagonalization (SBD) methods…

In this paper, we study the use of robust model independent bounded extremum seeking (ES) feedback control to improve the robustness of deep reinforcement learning (DRL) controllers for a class of nonlinear time-varying systems. DRL has the…

机器学习 · 计算机科学 2026-03-11 Shaifalee Saxena , Alan Williams , Rafael Fierro , Alexander Scheinker

The existing adaptive basal-bolus advisor (ABBA) was further developed to benefit patients under insulin therapy with multiple daily injections (MDI). Three different in silico experiments were conducted with the DMMS.R simulator to…

组织与器官 · 定量生物学 2019-06-21 Qingnan Sun , Marko V. Jankovic , Stavroula G. Mougiakakou

Models of the cortico-basal ganglia network and volume conductor models of the brain can provide insight into the mechanisms of action of deep brain stimulation (DBS). In this study, the coupling of a network model, under parkinsonian…

神经元与认知 · 定量生物学 2017-05-31 Christian Schmidt , Eleanor Dunn , Madeleine Lowery , Ursula van Rienen

Complex mechanical systems such as vehicle powertrains are inherently subject to multiple nonlinearities and uncertainties arising from parametric variations. Modeling errors are therefore unavoidable, making the transfer of control systems…

系统与控制 · 电气工程与系统科学 2026-02-13 Heisei Yonezawa , Ansei Yonezawa , Itsuro Kajiwara

The ability to direct a Probabilistic Boolean Network (PBN) to a desired state is important to applications such as targeted therapeutics in cancer biology. Reinforcement Learning (RL) has been proposed as a framework that solves a…

机器学习 · 计算机科学 2022-10-26 Sotiris Moschoyiannis , Evangelos Chatzaroulas , Vytenis Sliogeris , Yuhu Wu

Reconfigurable Intelligent Surfaces (RISs) offer a promising means of reshaping the wireless propagation environment, yet practical methods for configuring large passive arrays to achieve reliable signal equalization remain limited.…

信息论 · 计算机科学 2026-03-04 Gal Ben-Itzhak , Ender Ayanoglu