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Gene regulatory networks are powerful abstractions of biological systems. Since the advent of high-throughput measurement technologies in biology in the late 90s, reconstructing the structure of such networks has been a central…

定量方法 · 定量生物学 2018-12-20 Vân Anh Huynh-Thu , Guido Sanguinetti

Knowledge graph embedding (KGE), aiming to embed entities and relations into low-dimensional vectors, has attracted wide attention recently. However, the existing research is mainly based on the black-box neural models, which makes it…

计算与语言 · 计算机科学 2020-11-13 Xiaoyu Kou , Yankai Lin , Yuntao Li , Jiahao Xu , Peng Li , Jie Zhou , Yan Zhang

Predicting the evolution of spatiotemporal physical systems from sparse and scattered observational data poses a significant challenge in various scientific domains. Traditional methods rely on dense grid-structured data, limiting their…

机器学习 · 计算机科学 2024-03-29 Andrzej Dulny , Paul Heinisch , Andreas Hotho , Anna Krause

Humans can naturally understand an image in depth with the aid of rich knowledge accumulated from daily lives or professions. For example, to achieve fine-grained image recognition (e.g., categorizing hundreds of subordinate categories of…

计算机视觉与模式识别 · 计算机科学 2018-07-03 Tianshui Chen , Liang Lin , Riquan Chen , Yang Wu , Xiaonan Luo

Ensemble models comprising of deep Convolutional Neural Networks (CNN) have shown significant improvements in model generalization but at the cost of large computation and memory requirements. In this paper, we present a framework for…

计算机视觉与模式识别 · 计算机科学 2020-04-03 Umar Asif , Jianbin Tang , Stefan Harrer

Data-Free Knowledge Distillation (KD) allows knowledge transfer from a trained neural network (teacher) to a more compact one (student) in the absence of original training data. Existing works use a validation set to monitor the accuracy of…

机器学习 · 计算机科学 2024-07-30 Kuluhan Binici , Shivam Aggarwal , Nam Trung Pham , Karianto Leman , Tulika Mitra

Understanding gene regulation is a fundamental step towards understanding of how cells function and respond to environmental cues and perturbations. An important step in this direction is to infer the transcription factor-gene regulatory…

分子网络 · 定量生物学 2017-04-25 Yijie Wang , Dong-Yeon Cho , Hangnoh Lee , Justin Fear , Brian Oliver , Teresa M Przytycka

Accurately reconstructing Gene Regulatory Networks (GRNs) is crucial for understanding gene functions and disease mechanisms. Single-cell RNA sequencing (scRNA-seq) technology provides vast data for computational GRN reconstruction. Since…

分子网络 · 定量生物学 2025-12-16 Rijie Xi , Weikang Xu , Wei Xiong , Yuannong Ye , Bin Zhao

Many recent breakthroughs in machine learning have been enabled by the pre-trained foundation models. By scaling up model parameters, training data, and computation resources, foundation models have significantly advanced the…

人工智能 · 计算机科学 2023-10-06 Zhe Zhao , Qingyun Liu , Huan Gui , Bang An , Lichan Hong , Ed H. Chi

Although deep neural networks and in particular Convolutional Neural Networks have demonstrated state-of-the-art performance in image classification with relatively high efficiency, they still exhibit high computational costs, often…

计算机视觉与模式识别 · 计算机科学 2025-10-07 Martial Guidez , Stefan Duffner , Yannick Alpou , Oscar Röth , Christophe Garcia

Clinical trials are crucial for drug development but are time consuming, expensive, and often burdensome on patients. More importantly, clinical trials face uncertain outcomes due to issues with efficacy, safety, or problems with patient…

计算机与社会 · 计算机科学 2022-03-15 Tianfan Fu , Kexin Huang , Cao Xiao , Lucas M. Glass , Jimeng Sun

Due to the over-smoothing issue, most existing graph neural networks can only capture limited dependencies with their inherently finite aggregation layers. To overcome this limitation, we propose a new kind of graph convolution, called…

机器学习 · 计算机科学 2022-06-30 Qi Chen , Yifei Wang , Yisen Wang , Jiansheng Yang , Zhouchen Lin

Gene regulatory networks (GRNs) orchestrate cellular decision making and survival strategies. Inferring the structure of these networks from high-dimensional transcriptomics data is a central challenge in systems biology. Traditional…

应用统计 · 统计学 2025-08-01 Visweswaran Ravikumar , Aaresh Bhathena , Wajd N Al-Holou , Salar Fattahi , Arvind Rao

Foundation models for single-cell RNA sequencing (scRNA-seq) have shown promising capabilities in capturing gene expression patterns. However, current approaches face critical limitations: they ignore biological prior knowledge encoded in…

机器学习 · 计算机科学 2025-03-04 Mufan Qiu , Xinyu Hu , Fengwei Zhan , Sukwon Yun , Jie Peng , Ruichen Zhang , Bhavya Kailkhura , Jiekun Yang , Tianlong Chen

Diffusion distillation, exemplified by Distribution Matching Distillation (DMD), has shown great promise in few-step generation but often sacrifices quality for sampling speed. While integrating Reinforcement Learning (RL) into distillation…

机器学习 · 计算机科学 2026-04-22 Linwei Dong , Ruoyu Guo , Ge Bai , Zehuan Yuan , Yawei Luo , Changqing Zou

The recent surge of pervasive devices that generate dynamic data streams has underscored the necessity for learning systems to adapt continually to data distributional shifts. To tackle this challenge, the research community has put forth a…

计算机视觉与模式识别 · 计算机科学 2023-12-21 Jacopo Bonato , Francesco Pelosin , Luigi Sabetta , Alessandro Nicolosi

Models with similar performances exhibit significant disagreement in the predictions of individual samples, referred to as prediction churn. Our work explores this phenomenon in graph neural networks by investigating differences between…

机器学习 · 计算机科学 2023-10-03 Andreas Roth , Thomas Liebig

In recent years, many explanation methods have been proposed to explain individual classifications of deep neural networks. However, how to leverage the created explanations to improve the learning process has been less explored. As the…

计算机视觉与模式识别 · 计算机科学 2020-09-22 Jindong Gu , Zhiliang Wu , Volker Tresp

Agriculture is vital for global food security, but crops are vulnerable to diseases that impact yield and quality. While Convolutional Neural Networks (CNNs) accurately classify plant diseases using leaf images, their high computational…

计算机视觉与模式识别 · 计算机科学 2025-06-03 T. Ahmed , S. Jannat , Md. F. Islam , J. Noor

The increased amount of multi-modal medical data has opened the opportunities to simultaneously process various modalities such as imaging and non-imaging data to gain a comprehensive insight into the disease prediction domain. Recent…