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Open-source, multilingual medical large language models (LLMs) have the potential to serve linguistically diverse populations across different regions. Adapting generic LLMs for healthcare often requires continual pretraining, but this…

计算与语言 · 计算机科学 2024-09-10 Meng Zhou , Surajsinh Parmar , Anubhav Bhatti

Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

Histopathology Whole Slide Image (WSI) analysis serves as the gold standard for clinical cancer diagnosis in the daily routines of doctors. To develop computer-aided diagnosis model for WSIs, previous methods typically employ Multi-Instance…

计算机视觉与模式识别 · 计算机科学 2024-10-21 Honglin Li , Yunlong Zhang , Pingyi Chen , Zhongyi Shui , Chenglu Zhu , Lin Yang

Large language models (LLMs) constitute a breakthrough state-of-the-art Artificial Intelligence technology which is rapidly evolving and promises to aid in medical diagnosis. However, the correctness and the accuracy of their returns has…

计算与语言 · 计算机科学 2024-02-07 Dimitrios P. Panagoulias , Maria Virvou , George A. Tsihrintzis

Prompt learning has emerged as a promising paradigm for adapting pre-trained vision-language models (VLMs) to few-shot whole slide image (WSI) classification by aligning visual features with textual representations, thereby reducing…

计算机视觉与模式识别 · 计算机科学 2025-10-01 Junjie Zhou , Wei Shao , Yagao Yue , Wei Mu , Peng Wan , Qi Zhu , Daoqiang Zhang

Large language models (LLMs) have emerged as transformative tools in medicine, with strong capabilities in language understanding, reasoning, and structured information extraction. Radiation oncology is particularly well suited for LLM…

Due to the large size and lack of fine-grained annotation, Whole Slide Images (WSIs) analysis is commonly approached as a Multiple Instance Learning (MIL) problem. However, previous studies only learn from training data, posing a stark…

计算机视觉与模式识别 · 计算机科学 2024-11-28 Weiqin Zhao , Ziyu Guo , Yinshuang Fan , Yuming Jiang , Maximus Yeung , Lequan Yu

Large language models (LLMs) have shown remarkable progress in encoding clinical knowledge and responding to complex medical queries with appropriate clinical reasoning. However, their applicability in subspecialist or complex medical…

The rapidly emerging field of deep learning-based computational pathology has demonstrated promise in developing objective prognostic models from histology whole slide images. However, most prognostic models are either based on histology or…

Automated generation of diagnostic pathology reports directly from whole slide images (WSIs) is an emerging direction in computational pathology. Translating high-resolution tissue patterns into clinically coherent text remains difficult…

计算机视觉与模式识别 · 计算机科学 2025-12-16 Noorul Wahab , Nasir Rajpoot

Histopathological image analysis is an essential process for the discovery of diseases such as cancer. However, it is challenging to train CNN on whole slide images (WSIs) of gigapixel resolution considering the available memory capacity.…

图像与视频处理 · 电气工程与系统科学 2019-10-11 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Masashi Fukayama , Akihiko Yoshizawa , Masanobu Kitagawa , Tatsuya Harada

Pathology is essential for cancer diagnosis, with multiple instance learning (MIL) widely used for whole slide image (WSI) analysis. WSIs exhibit a natural hierarchy -- patches, regions, and slides -- with distinct semantic associations.…

计算机视觉与模式识别 · 计算机科学 2025-07-01 Peixiang Huang , Yanyan Huang , Weiqin Zhao , Junjun He , Lequan Yu

With the increasing application of large language models (LLMs) in the medical domain, evaluating these models' performance using benchmark datasets has become crucial. This paper presents a comprehensive survey of various benchmark…

While Large Language Models (LLMs) are emerging as a promising direction in computational pathology, the substantial computational cost of giga-pixel Whole Slide Images (WSIs) necessitates the use of Multi-Instance Learning (MIL) to enable…

计算机视觉与模式识别 · 计算机科学 2025-11-12 Zhenfeng Zhuang , Fangyu Zhou , Liansheng Wang

In many histopathology tasks, sample classification depends on morphological details in tissue or single cells that are only visible at the highest magnification. For a pathologist, this implies tedious zooming in and out, while for a…

计算机视觉与模式识别 · 计算机科学 2023-03-03 Ario Sadafi , Nassir Navab , Carsten Marr

Whole Slide Image (WSI) MLLMs are difficult to build and deploy because gigapixel slides induce thousands of visual tokens, while only a small fraction of regions is diagnostically relevant. Existing slide-level pathology MLLMs typically…

计算机视觉与模式识别 · 计算机科学 2026-03-13 Qingqiao Hu , Weimin Lyu , Meilong Xu , Kehan Qi , Xiaoling Hu , Saumya Gupta , Jiawei Zhou , Chao Chen

Large language models (LLMs) have demonstrated potential in the innovation of many disciplines. However, how they can best be developed for oncology remains underdeveloped. State-of-the-art OpenAI models were fine-tuned on a clinical…

人工智能 · 计算机科学 2024-06-17 Tristen Pool , Dennis Trujillo

In the past year, there has been a growing trend in applying Large Language Models (LLMs) to the field of medicine, particularly with the advent of advanced language models such as ChatGPT developed by OpenAI. However, there is limited…

计算与语言 · 计算机科学 2024-02-27 Fujian Jia , Xin Liu , Lixi Deng , Jiwen Gu , Chunchao Pu , Tunan Bai , Mengjiang Huang , Yuanzhi Lu , Kang Liu

Recent advances in multimodal large language models (LLMs) have highlighted their potential for medical and surgical applications. However, existing surgical datasets predominantly adopt a Visual Question Answering (VQA) format with…

计算机视觉与模式识别 · 计算机科学 2025-11-27 Tae-Min Choi , Tae Kyeong Jeong , Garam Kim , Jaemin Lee , Yeongyoon Koh , In Cheul Choi , Jae-Ho Chung , Jong Woong Park , Juyoun Park

Multimodal machine learning integrating histopathology and molecular data shows promise for cancer prognostication. We systematically reviewed studies combining whole slide images (WSIs) and high-throughput omics to predict overall…

定量方法 · 定量生物学 2025-07-30 Charlotte Jennings , Andrew Broad , Lucy Godson , Emily Clarke , David Westhead , Darren Treanor