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相关论文: GlyTwin: Digital Twin for Glucose Control in Type …

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Simulating glucose dynamics in individuals with type 1 diabetes (T1D) is critical for developing personalized treatments and supporting data-driven clinical decisions. Existing models often miss key physiological aspects and are difficult…

定量方法 · 定量生物学 2026-04-16 Valentina Roquemen-Echeverri , Taisa Kushner , Peter G. Jacobs , Clara Mosquera-Lopez

This paper presents a proof-of-concept digital twin framework for simulation-driven diabetes modeling using benchmark clinical data, synthetic temporal augmentation, and illustrative continuous glucose monitoring (CGM) analysis. Unlike…

机器学习 · 计算机科学 2026-05-13 Zarrin Monirzadeh

Type 1 diabetes mellitus (T1D) is characterized by insulin deficiency and blood glucose (BG) control issues. The state-of-the-art solution for continuous BG control is reinforcement learning (RL), where an agent can dynamically adjust…

机器学习 · 计算机科学 2026-01-26 Jingchi Jiang , Rujia Shen , Boran Wang , Yi Guan

Type 1 Diabetes (T1D) affects millions worldwide, requiring continuous monitoring to prevent severe hypo- and hyperglycemic events. While continuous glucose monitoring has improved blood glucose management, deploying predictive models on…

机器学习 · 计算机科学 2025-11-27 Mirko Paolo Barbato , Giorgia Rigamonti , Davide Marelli , Paolo Napoletano

Managing Type 1 Diabetes (T1D) demands constant vigilance as individuals strive to regulate their blood glucose levels and avoid dysglycemia, including hyperglycemia and hypoglycemia. Despite advances in automated insulin delivery (AID)…

机器学习 · 计算机科学 2026-02-26 Saman Khamesian , Asiful Arefeen , Maria Adela Grando , Bithika M. Thompson , Hassan Ghasemzadeh

High quality real world datasets are essential for advancing data driven approaches in type 1 diabetes (T1D) management, including personalized therapy design, digital twin systems, and glucose prediction models. However, progress in this…

机器学习 · 计算机科学 2025-06-19 Saman Khamesian , Asiful Arefeen , Bithika M. Thompson , Maria Adela Grando , Hassan Ghasemzadeh

The Glucose-Insulin-Glucagon nonlinear model [1-4] accurately describes how the body responds to exogenously supplied insulin and glucagon in patients affected by Type I diabetes. Based on this model, we design infusion rates of either…

组织与器官 · 定量生物学 2019-06-19 Afroza Shirin , Fabio Della Rossa , Isaac Klickstein , John Russell , Francesco Sorrentino

The rising rates of diabetes necessitate innovative methods for its management. Continuous glucose monitors (CGM) are small medical devices that measure blood glucose levels at regular intervals providing insights into daily patterns of…

The escalating prevalence of diabetes globally underscores the need for diabetes management. Recent research highlights the growing focus on digital biomarkers in diabetes management, with innovations in computational frameworks and…

人工智能 · 计算机科学 2024-04-22 Ziyi Zhou , Ming Cheng , Xingjian Diao , Yanjun Cui , Xiangling Li

The goal of this paper is to propose a new mathematical model for the combined effect of different treatments and lifestyles on the glucose-insulin dynamics of Type 2 diabetes (T2D) patients. The model gives the possibility to take into…

系统与控制 · 电气工程与系统科学 2023-01-11 Mohamad Al Ahdab , John Leth , Torben Knudsen , Peter Vestergaard , Henrik Clausen

In the world today, diabetic complications are a major factor in the disease's high mortality rate. Diabetes mellitus has been a major source of concern for decades due to its global prevalence and the resulting rising costs to individuals,…

医学物理 · 物理学 2023-10-18 Umme Hafsa Momy

Due to the sensitive nature of diabetes-related data, preventing them from being shared between studies, progress in the field of glucose prediction is hard to assess. To address this issue, we present GLYFE (GLYcemia Forecasting…

信号处理 · 电气工程与系统科学 2020-06-30 Maxime De Bois , Mehdi Ammi , Mounîm A. El Yacoubi

Effective management of Type 1 Diabetes requires continuous glucose monitoring and precise insulin adjustments to prevent hyperglycemia and hypoglycemia. With the growing adoption of wearable glucose monitors and mobile health applications,…

机器学习 · 计算机科学 2026-01-22 Giorgia Rigamonti , Mirko Paolo Barbato , Davide Marelli , Paolo Napoletano

People with type 1 diabetes (T1D) lack the ability to produce the insulin their bodies need. As a result, they must continually make decisions about how much insulin to self-administer to adequately control their blood glucose levels.…

机器学习 · 计算机科学 2020-09-22 Ian Fox , Joyce Lee , Rodica Pop-Busui , Jenna Wiens

Type 1 Diabetes is a chronic autoimmune condition in which the immune system attacks and destroys insulin-producing beta cells in the pancreas, resulting in little to no insulin production. Insulin helps glucose in your blood enter your…

定量方法 · 定量生物学 2025-02-04 Soon Jynn Chu , Nalaka Amarasiri , Sandesh Giri , Priyata Kafle

Type 1 diabetes eliminates the body's ability to produce insulin, making glucose regulation entirely dependent on external insulin delivery and the control algorithm. Existing closed-loop methods either rely on accurate patient-specific…

系统与控制 · 电气工程与系统科学 2026-05-12 Pukhrambam Akash Singh , Ratnangshu Das , Ahan Basu , Pushpak Jagtap

Accurate long-horizon glucose forecasting is critical for automated insulin delivery systems, which help people with type 1 diabetes (T1D) manage their glucose and avoid dangerous hypoglycemia. However, standard recursive long short-term…

机器学习 · 计算机科学 2026-05-19 Phat Tran , Neville Mehta , Clara Mosquera-Lopez , Robert H. Dodier , Lizhong Chen , Peter G. Jacobs

This paper proposes GluMind, a transformer-based multimodal framework designed for continual and long-term blood glucose forecasting. GluMind devises two attention mechanisms, including cross-attention and multi-scale attention, which…

The classification of diabetes and prediabetes by static glucose thresholds obscures the pathophysiological dysglycemia heterogeneity, primarily driven by insulin resistance (IR), beta-cell dysfunction, and incretin deficiency. This review…

机器学习 · 计算机科学 2025-11-07 Ahmed A. Metwally , Heyjun Park , Yue Wu , Tracey McLaughlin , Michael P. Snyder

Diabetes mellitus is a global health crisis characterized by poor blood sugar regulation, impacting millions of people worldwide and leading to severe complications and mortality. Although Type 1 Diabetes Mellitus (T1DM) has a lower number…

其他定量生物学 · 定量生物学 2025-04-14 Rinrada Jadsadaphongphaibool , Dadi Bi , Christian D. Lorenz , Yansha Deng , Robert Schober
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