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Deep neural networks (DNNs) have been widely applied to solve real-world regression problems. However, selecting optimal network structures remains a significant challenge. This study addresses this issue by linking neuron selection in DNNs…

统计计算 · 统计学 2025-09-30 Noah Yi-Ting Hung , Li-Hsiang Lin , Vince D. Calhoun

Bidirectional deep brain stimulation (bdDBS) devices capable of recording differential local field potentials (dLFP) enable neural recordings alongside clinical therapy. Efforts to identify objective signals of various brain disorders, or…

Behavioral and Psychological Symptoms of Dementia (BPSD) impact dementia care substantially, affecting both patients and caregivers. Effective management and early detection of BPSD are crucial to reduce the stress and burden on caregivers…

信号处理 · 电气工程与系统科学 2024-10-25 Benny Wei-Yun Hsu , Yu-Ming Chen , Yuan-Han Yang , Vincent S. Tseng

Parkinson's Disease (PD) is a neurodegenerative disease that currently does not have a cure. In order to facilitate disease management and reduce the speed of symptom progression, early diagnosis is essential. The current clinical,…

图像与视频处理 · 电气工程与系统科学 2019-09-11 Justin Quan , Lin Xu , Rene Xu , Tyrael Tong , Jean Su

Transcranial Electrical Stimulation (TCES) and Deep Brain Stimulation (DBS) are two different applications of electrical current to the brain used in different areas of medicine. Both have a similar frequency dependence of their efficiency,…

神经元与认知 · 定量生物学 2019-07-15 Markus Schütt , Jens Christian Claussen

This paper proposes Distributed Model Predictive Covariance Steering (DiMPCS) for multi-agent control under stochastic uncertainty. The scope of our approach is to blend covariance steering theory, distributed optimization and model…

机器人学 · 计算机科学 2025-01-28 Augustinos D. Saravanos , Isin M. Balci , Efstathios Bakolas , Evangelos A. Theodorou

Mechanical Circulatory Support (MCS) devices, implemented as a probabilistic deep sequence model. Existing mechanical simulators for MCS rely on oversimplifying assumptions and are insensitive to patient-specific behavior, limiting their…

机器学习 · 计算机科学 2024-05-30 Sophia Sun , Wenyuan Chen , Zihao Zhou , Sonia Fereidooni , Elise Jortberg , Rose Yu

Parkinson's disease is the world's fastest-growing neurological disorder. Research to elucidate the mechanisms of Parkinson's disease and automate diagnostics would greatly improve the treatment of patients with Parkinson's disease. Current…

机器学习 · 计算机科学 2024-02-20 Charlie Tran , Kai Shen , Kang Liu , Akshay Ashok , Adolfo Ramirez-Zamora , Jinghua Chen , Yulin Li , Ruogu Fang

Accurate early diagnosis and monitoring of neurodegenerative conditions is essential for effective disease management and delivery of medication and treatment. This research develops automatic methods for detecting brain imaging preclinical…

神经与进化计算 · 计算机科学 2019-10-15 Amir Dehsarvi , Stephen L. Smith

Electrical neuromodulation as a palliative treatment has been increasingly used in the control of epilepsy. However, current neuromodulations commonly implement predetermined actuation strategies and lack the capability of self-adaptively…

系统与控制 · 电气工程与系统科学 2022-08-23 Zhichao Liang , Zixiang Luo , Keyin Liu , Jingwei Qiu , Quanying Liu

We present a differentiable predictive control (DPC) methodology for learning constrained control laws for unknown nonlinear systems. DPC poses an approximate solution to multiparametric programming problems emerging from explicit nonlinear…

系统与控制 · 电气工程与系统科学 2021-07-27 Jan Drgona , Aaron Tuor , Soumya Vasisht , Elliott Skomski , Draguna Vrabie

Parkinson's Disease (PD) is one of the most prevalent neurodegenerative diseases that affects tens of millions of Americans. PD is highly progressive and heterogeneous. Quite a few studies have been conducted in recent years on predictive…

计算机视觉与模式识别 · 计算机科学 2019-05-08 Xi Sheryl Zhang , Lifang He , Kun Chen , Yuan Luo , Jiayu Zhou , Fei Wang

This work proposes the use of 3D convolutional variational autoencoders (CVAEs) to trace the changes and symptomatology produced by neurodegeneration in Parkinson's disease (PD). In this work, we present a novel approach to detect and…

图像与视频处理 · 电气工程与系统科学 2023-05-15 E. Delgado de las Heras , F. J. Martinez-Murcia , I. A. Illán , C. Jiménez-Mesa , D. Castillo-Barnes , J. Ramírez , J. M. Górriz

PPINtonus is a system for the early detection of Parkinson's Disease (PD) utilizing deep-learning tonal analysis, providing a cost-effective and accessible alternative to traditional neurological examinations. Partnering with the…

音频与语音处理 · 电气工程与系统科学 2024-06-06 Varun Reddy

Parkinson's disease (PD) is a common neurodegenerative disorder that severely diminishes patients' quality of life. Its global prevalence has increased markedly in recent decades. Current diagnostic workflows are complex and heavily reliant…

计算机视觉与模式识别 · 计算机科学 2026-03-12 Shuai Shao , Yan Wang , Shu Jiang , Shiyuan Zhao , Di Yang , Jiangtao Wang , Yutong Bai , Jianguo Zhang

Diagnosing Parkinson's disease is a complex task that requires the evaluation of several motor and non-motor symptoms. During diagnosis, gait abnormalities are among the important symptoms that physicians should consider. However, gait…

机器学习 · 计算机科学 2020-05-19 Imanne El Maachi , Guillaume-Alexandre Bilodeau , Wassim Bouachir

Neural population activity exhibits complex, nonlinear dynamics, varying in time, over trials, and across experimental conditions. Here, we develop Conditionally Linear Dynamical System (CLDS) models as a general-purpose method to…

神经元与认知 · 定量生物学 2025-10-31 Victor Geadah , Amin Nejatbakhsh , David Lipshutz , Jonathan W. Pillow , Alex H. Williams

Parkinson's Disease (PD) is characterized by disorders in motor function such as freezing of gait, rest tremor, rigidity, and slowed and hyposcaled movements. Medication with dopaminergic medication may alleviate those motor symptoms,…

In this paper, we present a data-driven model predictive control (MPC) scheme that is capable of stabilizing unknown linear time-invariant systems under the influence of process disturbances. To this end, Willems' lemma is used to predict…

系统与控制 · 电气工程与系统科学 2022-03-15 Christian Klöppelt , Julian Berberich , Frank Allgöwer , Matthias A. Müller

The rapid emergence of highly adaptable and reusable artificial intelligence (AI) models is set to revolutionize the medical field, particularly in the diagnosis and management of Parkinson's disease (PD). Currently, there are no effective…

机器学习 · 计算机科学 2025-02-18 Aite Zhao , Yongcan Liu , Xinglin Yu , Xinyue Xing