相关论文: Diffusing Alpha-emitters Radiation Therapy: In viv…

Alpha-DaRT is a new method for treating solid tumors with alpha particles, relying on the release of the alpha-emitting daughter atoms of radium-224 from sources inserted into the tumor. The most important model parameters for Alpha-DaRT…

Diffusing alpha-emitters Radiation Therapy (Alpha DaRT) enables the use of alpha particles for the treatment of solid tumors. It employs interstitial sources carrying a few uCi of Ra-224, designed to release its short-lived progeny, which…

Diffusing Alpha-emitters Radiation Therapy (DaRT) is a new method for treating solid tumors using alpha particles. Unlike conventional radiotherapy, where the physical models for dose calculations are known and routinely used, for DaRT a…

Diffusing alpha-emitters Radiation Therapy ("Alpha DaRT") is a new treatment modality focusing on the use of alpha particles against solid tumors. The introduction of Alpha DaRT in clinical settings calls for the development of detailed…

We used Monte Carlo simulations to study release of radium-224 daughter nuclei from the seed used for Diffusing Alpha-Emitters Radiation Therapy (DART). Calculated desorption probabilities for polonium-216 (15%) and lead-212 (12%) show that…

While spatial dose conformity delivered to a target volume has been pushed to its practical limits with advanced treatment planning and delivery, investigations in novel temporal dose delivery are unfolding new mechanisms. Recent advances…

Conventional cancer therapies include surgery, radiation therapy, chemotherapy, and, more recently, immunotherapy. These modalities are often combined to improve the therapeutic index. The general concept of radiation therapy is to increase…

Irradiations at Ultra High Dose Rate (UHDR) regimes, exceeding 40 Gy/s in single fractions lasting less than 200 ms, have shown an equivalent antitumor effect compared to conventional radio-therapy with reduced harm to normal tissues. This…

Laser-plasma accelerators can produce ultra short electron bunches in the femtosecond to picosecond duration range, resulting in high peak dose rates in comparison with clinical accelerators. This peculiar characteristic motivates their…

The analysis of the Lyman-alpha forest of absorption lines in quasar spectra has emerged as a potentially powerful technique to constrain the linear matter power spectrum. In most previous work, the amplitude of the ionizing background was…

With the advancement of treatment modalities in radiation therapy for cancer patients, outcomes have improved, but at the cost of increased treatment plan complexity and planning time. The accurate prediction of dose distributions would…

We performed a least-square fit analysis to reproduce the elastic angular distributions for $\alpha$ scattering on various nuclei form $^{12}$C to $^{208}$Pb for incident energies in the range 18 - 70 MeV using a velocity-dependent optical…

Purpose: This study explores the feasibility of dose-escalated proton beam therapy (dPBT) for Locally Advanced Pancreatic Cancer (LAPC) patients by modeling common patient scenarios using current clinically-adopted practices. Methods: Five…

Laser-driven proton sources have long been developed with an eye on their potential for medical application to radiation therapy. These sources are compact, versatile, and show peculiar characteristics such as extreme instantaneous dose…

Minibeam and microbeam radiation therapy promise improved treatment outcomes through reduced normal tissue toxicity at better tumor control rates. The lack of suitable compact radiation sources limits the clinical application of minibeams…

FLASH radiotherapy (FLASH-RT) is a new modality of radiotherapy by delivering doses with ultra-high dose rates. FLASH-RT has the ability to suppress tumor growth while sparing normal tissues, known as the FLASH effect. Although FLASH effect…

Flattening filter free (FFF) beams due to their non-uniformity, are sub-optimal for larger field sizes. The purpose of this study was to investigate the incident electron beam distributions that would produce flat FFF beams without the use…

We use detailed Lyalpha radiative transfer calculations to further test the claim of Rauch et al. (2008) that they have detected spatially extended faint Lyalpha emission from the elusive host population of Damped Lyalpha Absorption systems…

Extended radio sources in the sky require a dense sampling of short baselines to be properly imaged by interferometers. This problem arises in many areas of radio astronomy, such as in the study of galaxy clusters, which may host Mpc-scale…

FLASH is a new treatment modality that requires optimization of dose, dose rate, and LET. Here we validate these three quantities under FLASH conditions, which includes the quantum uncertainty in the time-dependent instantaneous dose rate…