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Identification of biomarkers is an emerging area in Oncology. In this article, we develop an efficient statistical procedure for classification of protein markers according to their effect on cancer progression. A high-dimensional…

应用统计 · 统计学 2021-01-08 Souvik Banerjee , Gajendra K. Vishwakarma , Atanu Bhattacharjee

Large language models (LLMs) have become important tools in solving biological problems, offering improvements in accuracy and adaptability over conventional methods. Several benchmarks have been proposed to evaluate the performance of…

Insufficient performance of optimization approaches for fitting of mathematical models is still a major bottleneck in systems biology. In this manuscript, the reasons and methodological challenges are summarized as well as their impact in…

性能 · 计算机科学 2019-07-09 Clemens Kreutz

Prediction of Overall Survival (OS) of brain cancer patients from multi-modal MRI is a challenging field of research. Most of the existing literature on survival prediction is based on Radiomic features, which does not consider either…

定量方法 · 定量生物学 2021-09-08 Subhashis Banerjee , Sushmita Mitra , Lawrence O. Hall

We consider a joint survival and mixed-effects model to explain the survival time from longitudinal data and high-dimensional covariates in a population. The longitudinal data is modeled using a non linear mixed-effects model to account for…

统计理论 · 数学 2025-08-06 Antoine Caillebotte , Estelle Kuhn , Sarah Lemler

Multi-label classification (MLC) is an ML task of predictive modeling in which a data instance can simultaneously belong to multiple classes. MLC is increasingly gaining interest in different application domains such as text mining,…

机器学习 · 计算机科学 2022-11-22 Ana Kostovska , Carola Doerr , Sašo Džeroski , Dragi Kocev , Panče Panov , Tome Eftimov

The preservation of soil health is a critical challenge in the 21st century due to its significant impact on agriculture, human health, and biodiversity. We provide the first deep investigation of the predictive potential of machine…

机器学习 · 统计学 2024-02-20 Rosa Aghdam , Xudong Tang , Shan Shan , Richard Lankau , Claudia Solís-Lemus

Human decision-making differs due to variation in both incentives and available information. This constitutes a substantial challenge for the evaluation of whether and how machine learning predictions can improve decision outcomes. We…

综合经济学 · 经济学 2020-11-24 Michael Allan Ribers , Hannes Ullrich

Predicting the probability of default (PD) of prospective loans is a critical objective for financial institutions. In recent years, machine learning (ML) algorithms have achieved remarkable success across a wide variety of prediction…

风险管理 · 定量金融 2025-06-25 Adrian Iulian Cristescu , Matteo Giordano

Recent advances in reasoning with large language models (LLMs) have demonstrated strong performance on complex mathematical tasks, including combinatorial optimization. Techniques such as Chain-of-Thought and In-Context Learning have…

人工智能 · 计算机科学 2025-09-17 Marylou Fauchard , Florian Carichon , Margarida Carvalho , Golnoosh Farnadi

Assessing the capabilities and risks of frontier AI systems is a critical area of research, and recent work has shown that repeated sampling from models can dramatically increase both. For instance, repeated sampling has been shown to…

人工智能 · 计算机科学 2025-10-08 Joshua Kazdan , Rylan Schaeffer , Youssef Allouah , Colin Sullivan , Kyssen Yu , Noam Levi , Sanmi Koyejo

Behavioral models are the key enablers for behavioral analysis of Software Product Lines (SPL), including testing and model checking. Active model learning comes to the rescue when family behavioral models are non-existent or outdated. A…

Non-neural Machine Learning (ML) and Deep Learning (DL) models are often used to predict system failures in the context of industrial maintenance. However, only a few researches jointly assess the effect of varying the amount of past data…

机器学习 · 计算机科学 2024-05-24 Nicolò Oreste Pinciroli Vago , Francesca Forbicini , Piero Fraternali

Medical practitioners use survival models to explore and understand the relationships between patients' covariates (e.g. clinical and genetic features) and the effectiveness of various treatment options. Standard survival models like the…

Breast cancer remains a significant global health challenge, with prognosis and treatment decisions largely dependent on clinical characteristics. Accurate prediction of patient outcomes is crucial for personalized treatment strategies.…

A new method called SurvLIME for explaining machine learning survival models is proposed. It can be viewed as an extension or modification of the well-known method LIME. The main idea behind the proposed method is to apply the Cox…

机器学习 · 计算机科学 2020-03-19 Maxim S. Kovalev , Lev V. Utkin , Ernest M. Kasimov

Molecular representation learning is pivotal for various molecular property prediction tasks related to drug discovery. Robust and accurate benchmarks are essential for refining and validating current methods. Existing molecular property…

化学物理 · 物理学 2024-06-27 Shikun Feng , Jiaxin Zheng , Yinjun Jia , Yanwen Huang , Fengfeng Zhou , Wei-Ying Ma , Yanyan Lan

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

计算与语言 · 计算机科学 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska

Recent approaches to training algorithm selectors in the black-box optimisation domain have advocated for the use of training data that is algorithm-centric in order to encapsulate information about how an algorithm performs on an instance,…

机器学习 · 计算机科学 2025-01-22 Quentin Renau , Emma Hart

Supporting student success requires collaboration among multiple stakeholders. Researchers have explored machine learning models for academic performance prediction; yet key challenges remain in ensuring these models are interpretable,…

人机交互 · 计算机科学 2025-05-12 Han Zhang , Yiyi Ren , Paula S. Nurius , Jennifer Mankoff , Anind K. Dey