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For supervised classification problems, this paper considers estimating the query's label probability through local regression using observed covariates. Well-known nonparametric kernel smoother and $k$-nearest neighbor ($k$-NN) estimator,…

机器学习 · 统计学 2022-07-25 Ruixing Cao , Akifumi Okuno , Kei Nakagawa , Hidetoshi Shimodaira

Time series are often complex and rich in information but sparsely labeled and therefore challenging to model. In this paper, we propose a self-supervised framework for learning generalizable representations for non-stationary time series.…

机器学习 · 计算机科学 2021-06-03 Sana Tonekaboni , Danny Eytan , Anna Goldenberg

Predicting cancer-associated clinical events is challenging in oncology. In Multiple Myeloma (MM), a cancer of plasma cells, disease progression is determined by changes in biomarkers, such as serum concentration of the paraprotein secreted…

Purpose: Automated medical image-based prediction of clinical outcomes, such as overall survival (OS), has great potential in improving patient prognostics and personalized treatment planning. We developed a deep regression framework using…

An open scientific challenge is how to classify events with reliable measures of uncertainty, when we have a mechanistic model of the data-generating process but the distribution over both labels and latent nuisance parameters is different…

机器学习 · 统计学 2024-07-02 Luca Masserano , Alex Shen , Michele Doro , Tommaso Dorigo , Rafael Izbicki , Ann B. Lee

Neuroblastoma is a strongly heterogeneous cancer with very diverse clinical courses that may vary from spontaneous regression to fatal progression; an accurate patient's risk estimation at diagnosis is essential to design appropriate tumor…

定量方法 · 定量生物学 2018-02-23 Valerio Maggio , Marco Chierici , Giuseppe Jurman , Cesare Furlanello

Longitudinal voice biomarkers provide a non-invasive source of information for monitoring Parkinson's disease progression, but their statistical analysis is difficult because repeated measurements from the same subject are correlated,…

机器学习 · 统计学 2026-04-28 Ran Tong , Lanruo Wang , Tong Wang , Wei Yan

Natural language processing (NLP) shows promise as a means to automate the labelling of hospital-scale neuroradiology magnetic resonance imaging (MRI) datasets for computer vision applications. To date, however, there has been no thorough…

Alzheimer's Disease (AD) research has shifted to focus on biomarker trajectories and their potential use in understanding the underlying AD-related pathological process. A conceptual framework was proposed in modern AD research that…

应用统计 · 统计学 2024-09-12 Zhuojun Tang , Yuxin Zhu , Kexin Zhang , Zheyu Wang

In order to find effective treatments for Alzheimer's disease (AD), we need to identify subjects at risk of AD as early as possible. To this end, recently developed disease progression models can be used to perform early diagnosis, as well…

定量方法 · 定量生物学 2020-03-11 Razvan V. Marinescu

Recent work has questioned the reliability of graph learning benchmarks, citing concerns around task design, methodological rigor, and data suitability. In this extended abstract, we contribute to this discussion by focusing on evaluation…

机器学习 · 计算机科学 2025-06-17 Filip Cornell , Oleg Smirnov , Gabriela Zarzar Gandler , Lele Cao

Long-run covariance matrix estimation is the building block of time series inference. The corresponding difference-based estimator, which avoids detrending, has attracted considerable interest due to its robustness to both smooth and abrupt…

统计方法学 · 统计学 2024-02-29 Lujia Bai , Weichi Wu

Data-driven methods for modeling dynamic systems have received considerable attention as they provide a mechanism for control synthesis directly from the observed time-series data. In the absence of prior assumptions on how the time-series…

最优化与控制 · 数学 2018-09-24 Atiye Alaeddini , Siavash Alemzadeh , Afshin Mesbahi , Mehran Mesbahi

Causal variable selection in time-varying treatment settings is challenging due to evolving confounding effects. Existing methods mainly focus on time-fixed exposures and are not directly applicable to time-varying scenarios. We propose a…

This paper studies nonparametric identification in market level demand models for differentiated products with heterogeneous consumers. We consider a general class of models that allows for the individual specific coefficients to vary…

计量经济学 · 经济学 2022-01-19 Fabian Dunker , Stefan Hoderlein , Hiroaki Kaido

In the analysis of prognosis studies with time-to-event outcomes, dichotomization of patients is often made. As the evaluations of prognostic capacity, the survivals of groups with high/low expression of the biomarker are often estimated by…

统计方法学 · 统计学 2023-06-01 Yi Zhou , Ao Huang , Satoshi Hattori

Linear causal analysis is central to a wide range of important application spanning finance, the physical sciences, and engineering. Much of the existing literature in linear causal analysis operates in the time domain. Unfortunately, the…

Time series forecasting is a crucial component of many important applications, ranging from forecasting the stock markets to energy load prediction. The high-dimensionality, velocity and variety of the data collected in these applications…

机器学习 · 计算机科学 2019-01-25 Nikolaos Passalis , Anastasios Tefas , Juho Kanniainen , Moncef Gabbouj , Alexandros Iosifidis

We propose a procedure for imputing missing values of time-dependent covariates in a survival model using fully conditional specification. Specifically, we focus on imputing missing values of a longitudinal marker in joint modeling of the…

统计方法学 · 统计学 2024-03-29 Havi Murad , Nirit Agay , Rachel Dankner

In observational studies, the identification of causal estimands depends on the no unmeasured confounding (NUC) assumption. As this assumption is not testable from observed data, sensitivity analysis plays an important role in observational…

统计方法学 · 统计学 2023-09-28 Md Abdul Basit , Mahbub A. H. M. Latif , Abdus S Wahed
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