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Current evaluation of large language models (LLMs) overwhelmingly prioritizes accuracy; however, in real-world and safety-critical applications, the ability to abstain when uncertain is equally vital for trustworthy deployment. We introduce…

计算与语言 · 计算机科学 2026-01-23 Sravanthi Machcha , Sushrita Yerra , Sahil Gupta , Aishwarya Sahoo , Sharmin Sultana , Hong Yu , Zonghai Yao

The comprehensive integration of machine learning healthcare models within clinical practice remains suboptimal, notwithstanding the proliferation of high-performing solutions reported in the literature. A predominant factor hindering…

图像与视频处理 · 电气工程与系统科学 2023-10-12 Ling Huang , Su Ruan , Yucheng Xing , Mengling Feng

Artificial intelligence (AI) systems accelerate medical workflows and improve diagnostic accuracy in healthcare, serving as second-opinion systems. However, the unpredictability of AI errors poses a significant challenge, particularly in…

Uncertainty quantification (UQ) is a critical aspect of artificial intelligence (AI) systems, particularly in high-risk domains such as healthcare, autonomous systems, and financial technology, where decision-making processes must account…

As artificial intelligence systems move toward clinical deployment, ensuring reliable prediction behavior is fundamental for safety-critical decision-making tasks. One proposed safeguard is selective prediction, where models can defer…

机器学习 · 计算机科学 2026-05-25 L. Julián Lechuga López , Farah E. Shamout , Tim G. J. Rudner

Reliable uncertainty quantification is crucial for trustworthy decision-making and the deployment of AI models in medical imaging. While prior work has explored the ability of neural networks to quantify predictive, epistemic, and aleatoric…

机器学习 · 统计学 2025-08-07 Simon Baur , Wojciech Samek , Jackie Ma

This study investigates uncertainty quantification in large language models (LLMs) for medical applications, emphasizing both technical innovations and philosophical implications. As LLMs become integral to clinical decision-making,…

Diagnostic testing provides a unique setting for studying and developing tools in classification theory. In such contexts, the concept of prevalence, i.e. the number of individuals with a given condition, is fundamental, both as an inherent…

Artificial intelligence models have shown strong potential in acute ischemic stroke imaging, particularly for lesion detection and segmentation using computed tomography and magnetic resonance imaging. However, most existing approaches…

图像与视频处理 · 电气工程与系统科学 2026-01-06 Md Rashadul Islam

Large language models are increasingly used to answer and verify scientific claims, yet existing evaluations typically assume that a model must always produce a definitive answer. In scientific settings, however, unsupported or uncertain…

计算与语言 · 计算机科学 2026-02-17 Samir Abdaljalil , Erchin Serpedin , Hasan Kurban

Artificial Intelligence (AI) holds the potential to dramatically improve patient care. However, it is not infallible, necessitating human-AI-collaboration to ensure safe implementation. One aspect of AI safety is the models' ability to…

计算机视觉与模式识别 · 计算机科学 2025-08-27 Anna M. Wundram , Christian F. Baumgartner

Uncertainty is a fundamental challenge in medical practice, but current medical AI systems fail to explicitly quantify or communicate uncertainty in a way that aligns with clinical reasoning. Existing XAI works focus on interpreting model…

人工智能 · 计算机科学 2025-09-24 Xiuyi Fan

Uncertainty in artificial intelligence (AI) predictions poses urgent legal and ethical challenges for AI-assisted decision-making. We examine two algorithmic interventions that act as guardrails for human-AI collaboration: selective…

计算机与社会 · 计算机科学 2025-08-12 Holli Sargeant , Mackenzie Jorgensen , Arina Shah , Adrian Weller , Umang Bhatt

The full acceptance of Deep Learning (DL) models in the clinical field is rather low with respect to the quantity of high-performing solutions reported in the literature. Particularly, end users are reluctant to rely on the rough…

图像与视频处理 · 电气工程与系统科学 2022-10-11 Benjamin Lambert , Florence Forbes , Alan Tucholka , Senan Doyle , Harmonie Dehaene , Michel Dojat

Medical multimodal learning faces significant challenges with missing modalities prevalent in clinical practice. Existing approaches assume equal contribution of modality and random missing patterns, neglecting inherent uncertainty in…

机器学习 · 计算机科学 2026-01-30 Linxiao Gong , Yang Liu , Lianlong Sun , Yulai Bi , Jing Liu , Xiaoguang Zhu

The importance of uncertainty quantification is increasingly recognized in the diverse field of machine learning. Accurately assessing model prediction uncertainty can help provide deeper understanding and confidence for researchers and…

机器学习 · 计算机科学 2024-12-03 Tianyi Chen , Yingzhou Lu , Nan Hao , Yuanyuan Zhang , Capucine Van Rechem , Jintai Chen , Tianfan Fu

The use of AI systems in healthcare for the early screening of diseases is of great clinical importance. Deep learning has shown great promise in medical imaging, but the reliability and trustworthiness of AI systems limit their deployment…

图像与视频处理 · 电气工程与系统科学 2023-05-17 Ke Zou , Zhihao Chen , Xuedong Yuan , Xiaojing Shen , Meng Wang , Huazhu Fu

Clinical dataset labels are rarely certain as annotators disagree and confidence is not uniform across cases. Typical aggregation procedures, such as majority voting, obscure this variability. In simple experiments on medical imaging…

Selective prediction systems can mitigate harms resulting from language model hallucinations by abstaining from answering in high-risk cases. Uncertainty quantification techniques are often employed to identify such cases, but are rarely…

计算与语言 · 计算机科学 2026-03-24 Edward Phillips , Fredrik K. Gustafsson , Sean Wu , Anshul Thakur , David A. Clifton

Uncertainty Quantification (UQ) is pivotal in enhancing the robustness, reliability, and interpretability of Machine Learning (ML) systems for healthcare, optimizing resources and improving patient care. Despite the emergence of ML-based…

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