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Lyophilization (aka freeze drying) is a typical process in pharmaceutical manufacturing used for improving the stability of various drug products, including its recent applications to mRNA vaccines. While extensive efforts have been…

计算工程、金融与科学 · 计算机科学 2025-12-03 Prakitr Srisuma , Gang Chen , Richard D. Braatz

This article is devoted to providing a review of mathematical formulations in which Polynomial Chaos Theory (PCT) has been incorporated into stochastic model predictive control (SMPC). In the past decade, PCT has been shown to provide a…

系统与控制 · 电气工程与系统科学 2024-06-18 Prabhat K. Mishra , Joel A. Paulson , Richard D. Braatz

A numerically efficient inverse method for parametric model uncertainty identification using maximum likelihood estimation is presented. The goal is to identify a probability model for a fixed number of model parameters based on a set of…

In this work, we propose a robust optimization approach to mitigate the impact of uncertainties in particle precipitation. Our model incorporates partial differential equations, more particular nonlinear and nonlocal population balance…

Robust optimization is a method for optimization under uncertainties in engineering systems and designs for applications ranging from aeronautics to nuclear. In a robust design process, parameter variability (or uncertainty) is incorporated…

统计计算 · 统计学 2022-10-17 Richa Verma , Dinesh Kumar , Kazuma Kobayashi , Syed Alam

Robustness analysis is very important in biology and neuroscience, to unravel behavioural patterns of systems that are conserved despite large parametric uncertainties. To make studies of probabilistic robustness more efficient and scalable…

定量方法 · 定量生物学 2026-01-08 Uros Sutulovic , Daniele Proverbio , Rami Katz , Giulia Giordano

Batteries are nonlinear dynamical systems that can be modeled by Porous Electrode Theory models. The aim of optimal fast charging is to reduce the charging time while keeping battery degradation low. Most past studies assume that model…

系统与控制 · 电气工程与系统科学 2024-10-14 Minsu Kim , Joachim Schaeffer , Marc D. Berliner , Berta Pedret Sagnier , Rolf Findeisen , Richard D. Braatz

As robotic systems move from highly structured environments to open worlds, incorporating uncertainty from dynamics learning or state estimation into the control pipeline is essential for robust performance. In this paper we present a…

系统与控制 · 电气工程与系统科学 2021-09-14 Robert Dyro , James Harrison , Apoorva Sharma , Marco Pavone

A probabilistic performance-oriented controller design approach based on polynomial chaos expansion and optimization is proposed for flight dynamic systems. Unlike robust control techniques where uncertainties are conservatively handled,…

系统与控制 · 电气工程与系统科学 2021-04-20 Dalong Shi , Xiang Fang , Florian Holzapfel

This paper presents an efficient methodology for the robust optimisation of Continuous Flow Polymerase Chain Reaction (CFPCR) devices. It enables the effects of uncertainties in device geometry, due to manufacturing tolerances, on the…

计算工程、金融与科学 · 计算机科学 2021-06-02 Yongxing Wang , Hazim A. Hamad , Jochen Voss , Harvey M. Thompson

Knowing the uncertainty in a prediction is critical when making expensive investment decisions and when patient safety is paramount, but machine learning (ML) models in drug discovery typically provide only a single best estimate and ignore…

机器学习 · 计算机科学 2021-06-03 Stanley E. Lazic , Dominic P. Williams

We present the design and development of a data stream system that captures data uncertainty from data collection to query processing to final result generation. Our system focuses on data that is naturally modeled as continuous random…

数据库 · 计算机科学 2009-09-15 Yanlei Diao , Boduo Li , Anna Liu , Liping Peng , Charles Sutton , Thanh Tran , Michael Zink

Data-driven forecasts of air quality have recently achieved more accurate short-term predictions. Despite their success, most of the current data-driven solutions lack proper quantifications of model uncertainty that communicate how much to…

机器学习 · 计算机科学 2021-12-07 Abdulmajid Murad , Frank Alexander Kraemer , Kerstin Bach , Gavin Taylor

This paper describes the treatment of systematic uncertainties in a Likelihood formalism. RooUnfold, which includes most of the unfolding methods that are commonly used in particle physics, is used to compare a newly implemented method…

高能物理 - 实验 · 物理学 2025-10-20 Lydia Brenner , Carsten Burgard , Vincent Alexander Croft

Probability Quantification (PQ) predictions of the efficacy of safety-critical protective systems is challenging. Yet, the popularity of PQ methodologies (e.g., Probabilistic Risk Assessment (PRA), Quantitative Risk Analysis (QRA) and…

系统与控制 · 电气工程与系统科学 2022-03-10 Martin Wortman , Ernest Kee , Pranav Kannan

This paper presents a systematic approach to the advanced control of continuous crystallization processes using model predictive control. We provide a tutorial introduction to controlling complex particle size distributions by integrating…

系统与控制 · 电气工程与系统科学 2026-02-04 Collin R. Johnson , Kerstin Wohlgemuth , Sergio Lucia

Uncertainty sets are at the heart of robust optimization (RO) because they play a key role in determining the RO models' tractability, robustness, and conservativeness. Different types of uncertainty sets have been proposed that model…

最优化与控制 · 数学 2021-07-13 Meysam Cheramin , Richard Li-Yang Chen , Jianqiang Cheng , Ali Pinar

Synthesising verifiably correct controllers for dynamical systems is crucial for safety-critical problems. To achieve this, it is important to account for uncertainty in a robust manner, while at the same time it is often of interest to…

系统与控制 · 电气工程与系统科学 2024-05-16 Luke Rickard , Alessandro Abate , Kostas Margellos

This article considers the $\mathcal{H}_\infty$ static output-feedback control for linear time-invariant uncertain systems with polynomial dependence on probabilistic time-invariant parametric uncertainties. By applying polynomial chaos…

系统与控制 · 电气工程与系统科学 2021-03-02 Yiming Wan , Dongying E. Shen , Sergio Lucia , Rolf Findeisen , Richard D. Braatz

Some applications of deep learning require not only to provide accurate results but also to quantify the amount of confidence in their prediction. The management of an electric power grid is one of these cases: to avoid risky scenarios,…

机器学习 · 计算机科学 2023-08-25 Michele Guerra , Simone Scardapane , Filippo Maria Bianchi
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