相关论文: Exploring Large Protein Language Models in Constra…

Protein fitness optimization is challenged by a vast combinatorial landscape where high-fitness variants are extremely sparse. Many current methods either underperform or require computationally expensive gradient-based sampling. We present…

The increase of web-scale weakly labelled image-text pairs have greatly facilitated the development of large-scale vision-language models (e.g., CLIP), which have shown impressive generalization performance over a series of downstream…

Protein language models (pLMs) have shown strong potential for zero-shot prediction of missense variant effects, yet systematic benchmarking on viral proteins remains limited, a critical gap given the need for proactive tools that can…

Pre-trained Language Models (PLMs) can be accurately fine-tuned for downstream text processing tasks. Recently, researchers have introduced several parameter-efficient fine-tuning methods that optimize input prompts or adjust a small number…

While protein language models (PLMs) are one of the most promising avenues of research for future de novo protein design, the way in which they transform sequences to hidden representations, as well as the information encoded in such…

In recent years, large language models (LLMs) have achieved remarkable success in natural language processing (NLP). LLMs require an extreme amount of parameters to attain high performance. As models grow into the trillion-parameter range,…

Large Language Models (LLMs), being generic task solvers, are versatile. However, despite the vast amount of data they are trained on, there are speculations about their adaptation capabilities to a new domain. Additionally, the simple…

High-quality textual training data is essential for the success of multimodal data processing tasks, yet outputs from image captioning models like BLIP and GIT often contain errors and anomalies that are difficult to rectify using…

This work introduces approaches to assessing phrase breaks in ESL learners' speech using pre-trained language models (PLMs) and large language models (LLMs). There are two tasks: overall assessment of phrase break for a speech clip and…

This paper aims to retrieve proteins with similar structures and semantics from large-scale protein dataset, facilitating the functional interpretation of protein structures derived by structural determination methods like cryo-Electron…

Large language models (LLMs) have significantly advanced natural language processing, excelling in areas like text generation, summarization, and question-answering. Despite their capabilities, these models face challenges when fine-tuned…

Protein language models (pLMs) produce per-residue representations that capture evolutionary and structural information, yet their mean-pooled sequence embeddings are not explicitly trained to reflect functional, evolutionary or structural…

Large Language Models (LLMs) pose a new paradigm of modeling and computation for information tasks. Recommendation systems are a critical application domain poised to benefit significantly from the sequence modeling capabilities and world…

Large language models (LLMs) have been widely adopted due to their remarkable performance across various applications, driving the accelerated development of a large number of diverse models. However, these individual LLMs show limitations…

Designing protein sequences that fold into a target 3-D structure, termed as the inverse folding problem, is central to protein engineering. However, it remains challenging due to the vast sequence space and the importance of local…

Contrastive Language-Image Pre-training (CLIP) models have demonstrated remarkable performance in zero-shot classification tasks, yet their efficacy in handling complex multi-object scenarios remains challenging. This study presents a…

Using Large Language Models (LLMs) for Process Mining (PM) tasks is becoming increasingly essential, and initial approaches yield promising results. However, little attention has been given to developing strategies for evaluating and…

Language is essentially a complex, intricate system of human expressions governed by grammatical rules. It poses a significant challenge to develop capable AI algorithms for comprehending and grasping a language. As a major approach,…

We present Fast Language-Image Pre-training (FLIP), a simple and more efficient method for training CLIP. Our method randomly masks out and removes a large portion of image patches during training. Masking allows us to learn from more…

Understanding biological processes, drug development, and biotechnological advancements requires a detailed analysis of protein structures and functions, a task that is inherently complex and time-consuming in traditional protein research.…