相关论文: Sensitive bioassay with an ultra-large dynamic ran…
Nucleic acid sensing is crucial for advancing diagnostics, therapeutic monitoring and molecu-lar biology research, by enabling the precise identification of DNA and RNA interactions. Here, we present an innovative sensing platform based on…
Micro-expressions (MEs) are involuntary, low-intensity, and short-duration facial expressions that often reveal an individual's genuine thoughts and emotions. Most existing ME analysis methods rely on window-level classification with fixed…
Fluorescence microscopy allows for a detailed inspection of cells, cellular networks, and anatomical landmarks by staining with a variety of carefully-selected markers visualized as color channels. Quantitative characterization of…
Living systems operate far from thermodynamic equilibrium. Enzymatic activity can induce broken detailed balance at the molecular scale. This molecular scale breaking of detailed balance is crucial to achieve biological functions such as…
In this work a combination of an ionization chamber with one-dimensional spatial resolution and a MicroCAT structure will be presented. The combination between gas gain operations and integrating front-end electronics yields a dynamic range…
A microscopic model of the effect of unbinding in diffusion limited aggregation based on a cellular automata approach is presented. The geometry resembles electrochemical deposition - ``ions'' diffuse at random from the top of a container…
Deploying deep learning models for plant disease detection on edge devices such as IoT sensors, smartphones, and embedded systems is severely constrained by limited computational resources and energy budgets. To address this challenge, we…
Existing works are dedicated to untangling atomized numerical components (features) from the hidden states of Large Language Models (LLMs). However, they typically rely on autoencoders constrained by some training-time regularization on…
Tunable mid-infrared lasers are essential for optical sensing and imaging. Existing technologies, however, face challenges in simultaneously achieving broadband spectral tunability and ultra-rapid scan rates, limiting their utility in…
While ordinary differential equations (ODEs) form the conceptual framework for modelling many cellular processes, specific situations demand stochastic models to capture the influence of noise. The most common formulation of stochastic…
This work demonstrates the Nd:YAG waveguide laser as an efficient platform for the bio-sensing. The waveguide was fabricated in the Nd:YAG crystal by the cooperation of the ultrafast laser writing and ion irradiation. As the laser…
Motivation: Bisulphite sequencing enables the detection of cytosine methylation. The sequence of the methylation states of cytosines on any given read forms a methylation pattern that carries substantially more information than merely…
Experimental characterization of blood flow in living organisms is crucial for understanding the development and function of cardiovascular systems, but there have been no techniques reported for snapshot imaging of thick samples in large…
Semantic segmentation of electron microscopy (EM) images of biological samples remains a challenge in the life sciences. EM data captures details of biological structures, sometimes with such complexity that even human observers can find it…
Biomolecular condensates form on timescales of seconds in cells upon environmental or compositional changes. Condensate formation is thus argued to act as a mechanism for sensing such changes and quickly initiating downstream processes,…
The lack of a simple operable method for longitudinal dynamic self-assembly of particles in a microchannel is one of the main problems in applying this technology to a wide range of researches, such as biomedical engineering, material…
Accurate modeling of the initial density profile is essential for studying heavy-ion collisions (HICs) with a transport model. Within the framework of the quantum molecular dynamics (QMD)-type model, a novel method for generating nuclear…
X-ray free-electron lasers (XFELs) with megahertz repetition rate can provide novel insights into structural dynamics of biological macromolecule solutions. However, very high dose rates can lead to beam-induced dynamics and structural…
Accurate intraoperative and postoperative diagnosis of spread through air spaces (STAS) is essential for guiding surgical decisions and postoperative management in lung cancer. However, histopathological assessment is labor-intensive and is…
Early cancer detection relies on invasive tissue biopsies or liquid biopsies limited by biomarker dilution. In contrast, tumour-derived extracellular vesicles (EVs) carrying biomarkers like melanoma-associated antigen-A (MAGE-A) are highly…