相关论文: Scaling Up ESM2 Architectures for Long Protein Seq…

Predicting the structure of interacting chains is crucial for understanding biological systems and developing new drugs. Large-scale pre-trained Protein Language Models (PLMs), such as ESM2, have shown impressive abilities in extracting…

Existing Protein Language Models (PLMs) often suffer from limited adaptability to multiple tasks and exhibit poor generalization across diverse biological contexts. In contrast, general-purpose Large Language Models (LLMs) lack the…

Considering the significance of proteins, computational protein science has always been a critical scientific field, dedicated to revealing knowledge and developing applications within the protein sequence-structure-function paradigm. In…

Machine learning is widely used to analyze biological sequence data. Non-sequential models such as SVMs or feed-forward neural networks are often used although they have no natural way of handling sequences of varying length. Recurrent…

Research on long non-coding RNAs (lncRNAs) has garnered significant attention due to their critical roles in gene regulation and disease mechanisms. However, the complexity and diversity of lncRNA sequences, along with the limited knowledge…

Text generating capabilities have undergone a substantial transformation with the introduction of large language models (LLMs). Electroencephalography (EEG)-based text production is still difficult, though, because it requires a lot of data…

Learning effective protein representations is critical in a variety of tasks in biology such as predicting protein functions. Recent sequence representation learning methods based on Protein Language Models (PLMs) excel in sequence-based…

A major limitation for the broader scope of problems solvable by transformers is the quadratic scaling of computational complexity with input size. In this study, we investigate the recurrent memory augmentation of pre-trained transformer…

Large Language Models (LLMs) are revolutionizing bioinformatics, enabling advanced analysis of DNA, RNA, proteins, and single-cell data. This survey provides a systematic review of recent advancements, focusing on genomic sequence modeling,…

Large language models (LLMs) have demonstrated remarkable capabilities across diverse domains, but their heavy resource demands make quantization-reducing precision to lower-bit formats-critical for efficient serving. While many…

Proteins perform much of the work in living organisms, and consequently the development of efficient computational methods for protein representation is essential for advancing large-scale biological research. Most current approaches…

Protein language models (PLMs) have emerged as powerful tools to detect complex patterns of protein sequences. However, the capability of PLMs to fully capture information on protein sequences might be limited by focusing on single…

This paper investigates the application of the transformer architecture in protein folding, as exemplified by DeepMind's AlphaFold project, and its implications for the understanding of so-called large language models. The prevailing…

Large language models have made remarkable progress in the field of molecular science, particularly in understanding and generating functional small molecules. This success is largely attributed to the effectiveness of molecular…

Robust and effective scaling of models from small to large width typically requires the precise adjustment of many algorithmic and architectural details, such as parameterization and optimizer choices. In this work, we propose a new…

Deep learning has contributed to major advances in the prediction of protein structure from sequence, a fundamental problem in structural bioinformatics. With predictions now approaching the accuracy of crystallographic resolution in some…

Resolving and rewriting references is fundamental in programming languages. Motivated by a real-world decompilation task, we abstract reference rewriting into the problems of direct and indirect indexing by permutation. We create synthetic…

Transformer-based sequence-to-sequence architectures, while achieving state-of-the-art results on a large number of NLP tasks, can still suffer from overfitting during training. In practice, this is usually countered either by applying…

Protein language models have excelled in a variety of tasks, ranging from structure prediction to protein engineering. However, proteins are highly diverse in functions and structures, and current state-of-the-art models including the…

Recent advancements in Large Language Models (LLMs)-based text embedding models primarily focus on data scaling or synthesis, yet limited exploration of training techniques and data quality, thereby constraining performance. In this work,…