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Deep learning-based drug response prediction (DRP) methods can accelerate the drug discovery process and reduce R\&D costs. Although the mainstream methods achieve high accuracy in predicting response regression values, the regression-aware…

生物大分子 · 定量生物学 2023-12-19 Kun Li , Wenbin Hu

Drug discovery is a critical task in biomedical natural language processing (NLP), yet explainable drug discovery remains underexplored. Meanwhile, large language models (LLMs) have shown remarkable abilities in natural language…

计算与语言 · 计算机科学 2025-02-28 Kai Zhang , Rui Zhu , Shutian Ma , Jingwei Xiong , Yejin Kim , Fabricio Murai , Xiaozhong Liu

MLLMs MLLMs are beginning to appear in clinical workflows, but their ability to perform complex medical reasoning remains unclear. We present Med-CMR, a fine-grained Medical Complex Multimodal Reasoning benchmark. Med-CMR distinguishes from…

Cross-modal medical image-report retrieval task plays a significant role in clinical diagnosis and various medical generative tasks. Eliminating heterogeneity between different modalities to enhance semantic consistency is the key challenge…

计算机视觉与模式识别 · 计算机科学 2025-05-21 Zeqiang Wei , Kai Jin , Xiuzhuang Zhou

Medication Recommendation (MR) is a promising research topic which booms diverse applications in the healthcare and clinical domains. However, existing methods mainly rely on sequential modeling and static graphs for representation…

机器学习 · 计算机科学 2025-01-16 Guanlin Liu , Xiaomei Yu , Zihao Liu , Xue Li , Xingxu Fan , Xiangwei Zheng

As healthcare increasingly turns to AI for scalable and trustworthy clinical decision support, ensuring reliability in model reasoning remains a critical challenge. Individual large language models (LLMs) are susceptible to hallucinations…

机器学习 · 计算机科学 2025-12-05 Huascar Sanchez , Briland Hitaj , Jules Bergmann , Linda Briesemeister

Objective: Large language models (LLMs) are attracting increasing interest in healthcare. This commentary evaluates the potential of LLMs to improve clinical prediction models (CPMs) for diagnostic and prognostic tasks, with a focus on…

计算机与社会 · 计算机科学 2025-11-07 Yusuf Yildiz , Goran Nenadic , Meghna Jani , David A. Jenkins

The importance of recommender systems is growing rapidly due to the exponential increase in the volume of content generated daily. This surge in content presents unique challenges for designing effective recommender systems. Key among these…

计算与语言 · 计算机科学 2025-06-12 Jiahao Tian , Jinman Zhao , Zhenkai Wang , Zhicheng Ding

Analyzing vast textual data and summarizing key information from electronic health records imposes a substantial burden on how clinicians allocate their time. Although large language models (LLMs) have shown promise in natural language…

With the rapid development of artificial intelligence, large language models (LLMs) have shown promising capabilities in mimicking human-level language comprehension and reasoning. This has sparked significant interest in applying LLMs to…

计算与语言 · 计算机科学 2023-11-06 Mingze Yuan , Peng Bao , Jiajia Yuan , Yunhao Shen , Zifan Chen , Yi Xie , Jie Zhao , Yang Chen , Li Zhang , Lin Shen , Bin Dong

Sequential Recommender Systems (SRS) aim to predict users' next interaction based on their historical behaviors, while still facing the challenge of data sparsity. With the rapid advancement of Multimodal Large Language Models (MLLMs),…

信息检索 · 计算机科学 2026-02-17 Mingyao Huang , Qidong Liu , Wenxuan Yang , Moranxin Wang , Yuqi Sun , Haiping Zhu , Feng Tian , Yan Chen

Multi-Behavior Recommendation (MBR) leverages multiple user interaction types (e.g., views, clicks, purchases) to enrich preference modeling and alleviate data sparsity issues in traditional single-behavior approaches. However, existing MBR…

信息检索 · 计算机科学 2026-03-27 Ranxu Zhang , Junjie Meng , Ying Sun , Ziqi Xu , Bing Yin , Hao Li , Yanyong Zhang , Chao Wang

The rapid evolution of artificial intelligence in drug discovery encounters challenges with generalization and extensive training, yet Large Language Models (LLMs) offer promise in reshaping interactions with complex molecular data. Our…

生物大分子 · 定量生物学 2024-12-20 He Cao , Zijing Liu , Xingyu Lu , Yuan Yao , Yu Li

Generative Large Language Models (LLMs) hold significant promise in healthcare, demonstrating capabilities such as passing medical licensing exams and providing clinical knowledge. However, their current use as information retrieval tools…

Multimodal (MM) learning is emerging as a promising paradigm in biomedical artificial intelligence (AI) applications, integrating complementary modality, which highlight different aspects of patient health. The scarcity of large…

人工智能 · 计算机科学 2025-12-01 Niccolo Marini , Zhaohui Liang , Sivaramakrishnan Rajaraman , Zhiyun Xue , Sameer Antani

Recent advancements in Large Language Models (LLMs) and Large Multi-modal Models (LMMs) have shown potential in various medical applications, such as Intelligent Medical Diagnosis. Although impressive results have been achieved, we find…

Cross-Domain Sequential Recommendation (CDSR) predicts user behavior by leveraging historical interactions across multiple domains, focusing on modeling cross-domain preferences and capturing both intra- and inter-sequence item…

信息检索 · 计算机科学 2026-03-02 Wangyu Wu , Zhenhong Chen , Wenqiao Zhang , Xianglin Qiu , Siqi Song , Xiaowei Huang , Fei Ma , Jimin Xiao

Chest X-rays (CXRs) are the most frequently performed imaging examinations in clinical settings. Recent advancements in Large Multimodal Models (LMMs) have enabled automated CXR interpretation, enhancing diagnostic accuracy and efficiency.…

计算机视觉与模式识别 · 计算机科学 2025-05-06 Qingqiu Li , Zihang Cui , Seongsu Bae , Jilan Xu , Runtian Yuan , Yuejie Zhang , Rui Feng , Quanli Shen , Xiaobo Zhang , Junjun He , Shujun Wang

Medical texts, particularly electronic medical records (EMRs), are a cornerstone of modern healthcare, capturing critical information about patient care, diagnoses, and treatments. These texts hold immense potential for advancing clinical…

计算与语言 · 计算机科学 2025-11-12 Mucheng Ren , Yucheng Yan , He Chen , Danqing Hu , Jun Xu , Xian Zeng

Recent advancements in Multimodal Large Language Models (MLLMs) have demonstrated significant potential in recommendation systems. However, the effective application of MLLMs to multimodal sequential recommendation remains unexplored: A)…

信息检索 · 计算机科学 2025-12-25 Haoyu Wang , Yitong Wang , Jining Wang