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Cognitive function depends on an adaptive balance between flexible dynamics and integrative processes in distributed cortical networks. Patterns of zero-lag synchrony likely underpin numerous perceptual and cognitive functions.…

神经元与认知 · 定量生物学 2014-09-16 Leonardo L. Gollo , Michael Breakspear

Macroscopic oscillations of different brain regions show multiple phase relationships that are persistent across time and have been implicated routing information. Various cellular level mechanisms influence the network dynamics and…

神经元与认知 · 定量生物学 2019-06-19 Gregory Dumont , Boris Gutkin

The relationship between cell density and velocity is often assumed to be negative, reflecting crowding-induced suppression of movement. However, observations across systems reveal a more nuanced picture: while some emphasize contact…

软凝聚态物质 · 物理学 2025-08-27 Hengdong Lu , Tianxiang Ma , Amin Doostmohammadi

The phase field model can accurately simulate the evolution of microstructures with complex morphologies, and it has been widely used for cell modeling in the last two decades. However, compared to other cellular models such as the…

生物物理 · 物理学 2022-06-13 Xiangyu Kuang , Guoye Guan , Chao Tang , Lei Zhang

Understanding the activity of large populations of neurons is difficult due to the combinatorial complexity of possible cell-cell interactions. To reduce the complexity, coarse-graining had been previously applied to experimental neural…

神经元与认知 · 定量生物学 2021-03-24 Mia C. Morrell , Audrey J. Sederberg , Ilya Nemenman

Serotonin (5-hydroxytryptamine) is a major neurotransmitter whose release from densely distributed serotonergic varicosities shapes plasticity and network integration throughout the brain, yet its extracellular dynamics remain poorly…

组织与器官 · 定量生物学 2026-05-21 Merlin Pelz , Skirmantas Janusonis , Gregory Handy

Structural and functional heterogeneity are hallmarks of cortical circuits, from broad degree distributions in the mouse connectome to diverse intrinsic neuronal timescales. Yet a mechanistic link between connectivity heterogeneity and…

神经元与认知 · 定量生物学 2026-03-05 Marco Zenari , Luca Taffarello , Luca Mazzucato , Amos Maritan , Samir Suweis

Complex dynamical systems are often modeled as networks, with nodes representing dynamical units which interact through the network's links. Gene regulatory networks, responsible for the production of proteins inside a cell, are an example…

统计力学 · 物理学 2009-09-30 Zoran Levnajić

Multimodal MRI offers complementary multi-scale information to characterize the brain structure. However, it remains challenging to effectively integrate multimodal MRI while achieving neuroscience interpretability. Here we propose to use…

神经元与认知 · 定量生物学 2025-12-15 Chengzhi Xia , Jianwei Chen , Yixuan Jiang , Qi Yan , Chao Li

Understanding the structure and dynamics of liquids is pivotal for the study of larger spatiotemporal processes, especially in glass-forming materials at low temperatures. Density scaling, observed in many molecular systems through…

软凝聚态物质 · 物理学 2024-10-29 Jaehyeok Jin , David R. Reichman , Jeppe C. Dyre , Ulf R. Pedersen

Subdiffusion has been proposed as an explanation of various kinetic phenomena inside living cells. In order to fascilitate large-scale computational studies of subdiffusive chemical processes, we extend a recently suggested mesoscopic model…

偏微分方程分析 · 数学 2018-02-19 Emilie Blanc , Stefan Engblom , Andreas Hellander , Per Lötstedt

Functional brain networks can change rapidly as a function of stimuli or cognitive shifts. Tracking dynamic functional connectivity is particularly challenging as it requires estimating the structure of the network at each moment as well as…

统计方法学 · 统计学 2024-04-30 Wan-Chi Hsin , Uri T. Eden , Emily P. Stephen

The spatial structure of the cell is highly organized at all levels: from small complexes and assemblies, to local nano- and micro-clusters, to global, micrometer scales across and between cells. We suggest that this multiscale spatial cell…

生物大分子 · 定量生物学 2013-08-06 Ruth Nussinov

In this paper, we develop a novel unfitted multiscale framework that combines two separate scales represented by only one single computational mesh. Our framework relies on a mixed zooming technique where we zoom at regions of interest to…

计算工程、金融与科学 · 计算机科学 2022-05-27 Ehsan Mikaeili , Susanne Claus , Pierre Kerfriden

Neural computation is associated with the emergence, reconfiguration and dissolution of cell assemblies in the context of varying oscillatory states. Here, we describe the complex spatio-temporal dynamics of cell assemblies through temporal…

神经元与认知 · 定量生物学 2020-01-20 Nicola Pedreschi , Christophe Bernard , Wesley Clawson , Pascale Quilichini , Alain Barrat , Demian Battaglia

Dynamical entities interacting with each other on complex networks often exhibit multistability. The stability of a desired steady regime (e.g., a synchronized state) to large perturbations is critical in the operation of many real-world…

混沌动力学 · 物理学 2017-03-22 Chiranjit Mitra , Anshul Choudhary , Sudeshna Sinha , Jürgen Kurths , Reik V. Donner

Power systems are subject to fundamental changes due to the increasing infeed of decentralised renewable energy sources and storage. The decentralised nature of the new actors in the system requires new concepts for structuring the power…

适应与自组织系统 · 物理学 2020-04-22 Lia Strenge , Paul Schultz , Jürgen Kurths , Jörg Raisch , Frank Hellmann

Self-organized criticality (SOC) refers to the ability of complex systems to evolve towards a 2nd-order phase transition at which interactions between system components lead to scale-invariant events beneficial for system performance. For…

神经元与认知 · 定量生物学 2021-05-18 Dietmar Plenz , Tiago L. Ribeiro , Stephanie R. Miller , Patrick A. Kells , Ali Vakili , Elliott L. Capek

Collective motion is an ubiquitous phenomenon in nature, inspiring engineers, physicists and mathematicians to develop mathematical models and bio-inspired designs. Collective motion at small to medium group sizes ($\sim$10-1000…

机器学习 · 计算机科学 2024-01-19 Utkarsh Pratiush , Arshed Nabeel , Vishwesha Guttal , Prathosh AP

To attain the targeted data rates of next generation cellular networks requires dense deployment of small cells in addition to macro cells which provide wide coverage. Dynamic radio resource management is crucial to the success of such…

信息论 · 计算机科学 2019-03-05 Fei Teng , Dongning Guo
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