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Cryo-electron tomography (Cryo-ET) is a powerful tool in structural biology for 3D visualization of cells and biological systems at resolutions sufficient to identify individual proteins in situ. The measurements are collected by tilting…

信号处理 · 电气工程与系统科学 2025-09-03 Vinith Kishore , Valentin Debarnot , AmirEhsan Khorashadizadeh , Ivan Dokmanić

Cryo-Electron Tomography (cryo-ET) is a new 3D imaging technique with unprecedented potential for resolving submicron structural detail. Existing volume visualization methods, however, cannot cope with its very low signal-to-noise ratio. In…

定量方法 · 定量生物学 2026-03-27 Ngan Nguyen , Ciril Bohak , Dominik Engel , Peter Mindek , Ondřej Strnad , Peter Wonka , Sai Li , Timo Ropinski , Ivan Viola

Cryo-Electron Tomography (cryo-ET) is a 3D imaging technology that enables the visualization of subcellular structures in situ at near-atomic resolution. Cellular cryo-ET images help in resolving the structures of macromolecules and…

Although supervised image denoising networks have shown remarkable performance on synthesized noisy images, they often fail in practice due to the difference between real and synthesized noise. Since clean-noisy image pairs from the real…

图像与视频处理 · 电气工程与系统科学 2023-10-17 Hyemi Jang , Junsung Park , Dahuin Jung , Jaihyun Lew , Ho Bae , Sungroh Yoon

Cryo-Electron Tomography (cryo-ET) is a 3D imaging technology facilitating the study of macromolecular structures at near-atomic resolution. Recent volumetric segmentation approaches on cryo-ET images have drawn widespread interest in…

计算机视觉与模式识别 · 计算机科学 2024-07-02 Haoran Li , Xingjian Li , Jiahua Shi , Huaming Chen , Bo Du , Daisuke Kihara , Johan Barthelemy , Jun Shen , Min Xu

Cryo-electron tomography (cryo-ET) provides direct 3D visualization of macromolecules inside the cell, enabling analysis of their in situ morphology. This morphology can be regarded as an SE(3)-invariant, denoised volumetric representation…

计算机视觉与模式识别 · 计算机科学 2026-01-06 Mostofa Rafid Uddin , Mahek Vora , Qifeng Wu , Muyuan Chen , Min Xu

Self-supervised learning has been increasingly investigated for low-dose computed tomography (LDCT) image denoising, as it alleviates the dependence on paired normal-dose CT (NDCT) data, which are often difficult to collect. However, many…

计算机视觉与模式识别 · 计算机科学 2026-05-25 Yichao Liu , Zongru Shao , Yueyang Teng , Junwen Guo

Optical Coherence Tomography (OCT) is pervasive in both the research and clinical practice of Ophthalmology. However, OCT images are strongly corrupted by noise, limiting their interpretation. Current OCT denoisers leverage assumptions on…

图像与视频处理 · 电气工程与系统科学 2020-08-19 Guillaume Gisbert , Neel Dey , Hiroshi Ishikawa , Joel Schuman , James Fishbaugh , Guido Gerig

Cryo-electron microscopy (cryo-EM) has achieved near-atomic level resolution of biomolecules by reconstructing 2D micrographs. However, the resolution and accuracy of the reconstructed particles are significantly reduced due to the…

计算机视觉与模式识别 · 计算机科学 2024-01-03 Jing Zhang , Tengfei Zhao , ShiYu Hu , Xin Zhao

Cryo-electron tomography (Cryo-ET) is a 3D imaging technique that enables the systemic study of shape, abundance, and distribution of macromolecular structures in single cells in near-atomic resolution. However, the systematic and efficient…

生物大分子 · 定量生物学 2021-06-29 Kai Yi , Jianye Pang , Yungeng Zhang , Xiangrui Zeng , Min Xu

Cryo-electron microscopy (cryo-EM) enables single-particle analysis of biological macromolecules under strict low-dose imaging conditions, but the resulting micrographs often exhibit extremely low signal-to-noise ratios and weak particle…

计算机视觉与模式识别 · 计算机科学 2026-04-21 Xiaoqi Wu , Xueying Zhan , Wen Li , Junhao Wu , Xin Huang , Min Xu

We propose a general framework for solving inverse problems in the presence of noise that requires no signal prior, no noise estimate, and no clean training data. We only require that the forward model be available and that the noise be…

计算机视觉与模式识别 · 计算机科学 2020-06-12 Hirofumi Kobayashi , Ahmet Can Solak , Joshua Batson , Loic A. Royer

Many microscopy applications are limited by the total amount of usable light and are consequently challenged by the resulting levels of noise in the acquired images. This problem is often addressed via (supervised) deep learning based…

图像与视频处理 · 电气工程与系统科学 2020-08-20 Anna S. Goncharova , Alf Honigmann , Florian Jug , Alexander Krull

Recently, denoising methods based on supervised learning have exhibited promising performance. However, their reliance on external datasets containing noisy-clean image pairs restricts their applicability. To address this limitation,…

计算机视觉与模式识别 · 计算机科学 2023-07-21 Jaekyun Ko , Sanghwan Lee

Cryo-electron tomography (cryo-ET) enables 3D visualization of cellular structures. Accurate reconstruction of high-resolution volumes is complicated by the very low signal-to-noise ratio and a restricted range of sample tilts. Recent…

图像与视频处理 · 电气工程与系统科学 2026-03-03 Vinith Kishore , Valentin Debarnot , AmirEhsan Khorashadizadeh , Ricardo D. Righetto , Benjamin D. Engel , Ivan Dokmanić

Unlike single image task, stereo image enhancement can use another view information, and its key stage is how to perform cross-view feature interaction to extract useful information from another view. However, complex noise in low-light…

计算机视觉与模式识别 · 计算机科学 2024-01-17 Minghua Zhao , Xiangdong Qin , Shuangli Du , Xuefei Bai , Jiahao Lyu , Yiguang Liu

Self-supervised frameworks that learn denoising models with merely individual noisy images have shown strong capability and promising performance in various image denoising tasks. Existing self-supervised denoising frameworks are mostly…

计算机视觉与模式识别 · 计算机科学 2020-10-26 Yaochen Xie , Zhengyang Wang , Shuiwang Ji

Many imaging modalities involve reconstruction of unknown objects from collections of noisy projections related by random rotations. In one of these modalities, cryogenic electron microscopy (cryo-EM), the extremely low signal-to-noise…

图像与视频处理 · 电气工程与系统科学 2025-10-16 Joakim Andén , Justus Sagemüller

Inverse problems in image reconstruction are fundamentally complicated by unknown noise properties. Classical iterative deconvolution approaches amplify noise and require careful parameter selection for an optimal trade-off between…

计算机视觉与模式识别 · 计算机科学 2023-08-21 Mikhail Papkov , Kaupo Palo , Leopold Parts

Tunneling spectroscopy is an important tool for the study of both real-space and momentum-space electronic structure of correlated electron systems. However, such measurements often yield noisy data. Machine learning provides techniques to…

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